IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0070588.html
   My bibliography  Save this article

Cost-Effectiveness of a Community Pharmacist Intervention in Patients with Depression: A Randomized Controlled Trial (PRODEFAR Study)

Author

Listed:
  • Maria Rubio-Valera
  • Judith Bosmans
  • Ana Fernández
  • Maite Peñarrubia-María
  • Marian March
  • Pere Travé
  • Juan A Bellón
  • Antoni Serrano-Blanco

Abstract

Background: Non-adherence to antidepressants generates higher costs for the treatment of depression. Little is known about the cost-effectiveness of pharmacist's interventions aimed at improving adherence to antidepressants. The study aimed to evaluate the cost-effectiveness of a community pharmacist intervention in comparison with usual care in depressed patients initiating treatment with antidepressants in primary care. Methods: Patients were recruited by general practitioners and randomized to community pharmacist intervention (87) that received an educational intervention and usual care (92). Adherence to antidepressants, clinical symptoms, Quality-Adjusted Life-Years (QALYs), use of healthcare services and productivity losses were measured at baseline, 3 and 6 months. Results: There were no significant differences between groups in costs or effects. From a societal perspective, the incremental cost-effectiveness ratio (ICER) for the community pharmacist intervention compared with usual care was €1,866 for extra adherent patient and €9,872 per extra QALY. In terms of remission of depressive symptoms, the usual care dominated the community pharmacist intervention. If willingness to pay (WTP) is €30,000 per extra adherent patient, remission of symptoms or QALYs, the probability of the community pharmacist intervention being cost-effective was 0.71, 0.46 and 0.75, respectively (societal perspective). From a healthcare perspective, the probability of the community pharmacist intervention being cost-effective in terms of adherence, QALYs and remission was of 0.71, 0.76 and 0.46, respectively, if WTP is €30,000. Conclusion: A brief community pharmacist intervention addressed to depressed patients initiating antidepressant treatment showed a probability of being cost-effective of 0.71 and 0.75 in terms of improvement of adherence and QALYs, respectively, when compared to usual care. Regular implementation of the community pharmacist intervention is not recommended. Trial Registration: ClinicalTrials.gov NCT00794196

Suggested Citation

  • Maria Rubio-Valera & Judith Bosmans & Ana Fernández & Maite Peñarrubia-María & Marian March & Pere Travé & Juan A Bellón & Antoni Serrano-Blanco, 2013. "Cost-Effectiveness of a Community Pharmacist Intervention in Patients with Depression: A Randomized Controlled Trial (PRODEFAR Study)," PLOS ONE, Public Library of Science, vol. 8(8), pages 1-10, August.
    • Handle: RePEc:plo:pone00:0070588
    DOI: 10.1371/journal.pone.0070588
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0070588
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0070588&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0070588?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Judith Bosmans & Oscar Brook & Hein Hout & Martine Bruijne & Hugo Nieuwenhuyse & Lex Bouter & Wim Stalman & Maurits Tulder, 2007. "Cost Effectiveness of a Pharmacy-Based Coaching Programme to Improve Adherence to Antidepressants," PharmacoEconomics, Springer, vol. 25(1), pages 25-37, January.
    2. Colin D Mathers & Dejan Loncar, 2006. "Projections of Global Mortality and Burden of Disease from 2002 to 2030," PLOS Medicine, Public Library of Science, vol. 3(11), pages 1-20, November.
    3. Glick, Henry A & Doshi, Jalpa A & Sonnad, Seema S & Polsky, Daniel, 2007. "Economic Evaluation in Clinical Trials," OUP Catalogue, Oxford University Press, number 9780198529972.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Perraudin, Clémence & Bugnon, Olivier & Pelletier-Fleury, Nathalie, 2016. "Expanding professional pharmacy services in European community setting: Is it cost-effective? A systematic review for health policy considerations," Health Policy, Elsevier, vol. 120(12), pages 1350-1362.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Jia Lu & Shabana Jamani & Joseph Benjamen & Eric Agbata & Olivia Magwood & Kevin Pottie, 2020. "Global Mental Health and Services for Migrants in Primary Care Settings in High-Income Countries: A Scoping Review," IJERPH, MDPI, vol. 17(22), pages 1-28, November.
    2. Matthijs van den Berg & Filip Smit & Theo Vos & Pieter H M van Baal, 2011. "Cost-Effectiveness of Opportunistic Screening and Minimal Contact Psychotherapy to Prevent Depression in Primary Care Patients," PLOS ONE, Public Library of Science, vol. 6(8), pages 1-7, August.
    3. Ide, Hiroo & Mollahaliloglu, Salih, 2009. "How firms set prices for medical materials: A multi-country study," Health Policy, Elsevier, vol. 92(1), pages 73-78, September.
    4. Noémi Kreif & Richard Grieve & M. Zia Sadique, 2013. "Statistical Methods For Cost‐Effectiveness Analyses That Use Observational Data: A Critical Appraisal Tool And Review Of Current Practice," Health Economics, John Wiley & Sons, Ltd., vol. 22(4), pages 486-500, April.
    5. Eldon Spackman & Stewart Richmond & Mark Sculpher & Martin Bland & Stephen Brealey & Rhian Gabe & Ann Hopton & Ada Keding & Harriet Lansdown & Sara Perren & David Torgerson & Ian Watt & Hugh MacPherso, 2014. "Cost-Effectiveness Analysis of Acupuncture, Counselling and Usual Care in Treating Patients with Depression: The Results of the ACUDep Trial," PLOS ONE, Public Library of Science, vol. 9(11), pages 1-12, November.
    6. Peele, Morgan & Wolf, Sharon, 2020. "Predictors of anxiety and depressive symptoms among teachers in Ghana: Evidence from a randomized controlled trial," Social Science & Medicine, Elsevier, vol. 253(C).
    7. Carsten Hinrichsen & Vibeke Jenny Koushede & Katrine Rich Madsen & Line Nielsen & Nanna Gram Ahlmark & Ziggi Ivan Santini & Charlotte Meilstrup, 2020. "Implementing Mental Health Promotion Initiatives—Process Evaluation of the ABCs of Mental Health in Denmark," IJERPH, MDPI, vol. 17(16), pages 1-26, August.
    8. Gianni Tognoni & Alejandro Macchia, 2020. "Health as a Human Right: A Fake News in a Post-human World?," Development, Palgrave Macmillan;Society for International Deveopment, vol. 63(2), pages 270-276, December.
    9. G. Sagoo & S. Mohammed & G. Barton & G. Norbury & J. Ahn & C. Ogilvie & M. Kroese, 2015. "Cost Effectiveness of Using Array-CGH for Diagnosing Learning Disability," Applied Health Economics and Health Policy, Springer, vol. 13(4), pages 421-432, August.
    10. Renske Kok & Mauricio Avendano & Teresa Bago d’Uva & Johan Mackenbach, 2012. "Can Reporting Heterogeneity Explain Differences in Depressive Symptoms Across Europe?," Social Indicators Research: An International and Interdisciplinary Journal for Quality-of-Life Measurement, Springer, vol. 105(2), pages 191-210, January.
    11. Theresa Tawiah & Kristian Schultz Hansen & Frank Baiden & Jane Bruce & Mathilda Tivura & Rupert Delimini & Seeba Amengo-Etego & Daniel Chandramohan & Seth Owusu-Agyei & Jayne Webster, 2016. "Cost-Effectiveness Analysis of Test-Based versus Presumptive Treatment of Uncomplicated Malaria in Children under Five Years in an Area of High Transmission in Central Ghana," PLOS ONE, Public Library of Science, vol. 11(10), pages 1-18, October.
    12. Emmanuel Peprah & Elisabet Caler & Anya Snyder & Fassil Ketema, 2020. "Deconstructing Syndemics: The Many Layers of Clustering Multi-Comorbidities in People Living with HIV," IJERPH, MDPI, vol. 17(13), pages 1-7, June.
    13. Qiumei Xu & Fangfen Yuan & Xuemei Shen & Hui Wen & Wei Li & Bei Cheng & Jing Wu, 2014. "Polymorphisms of C242T and A640G in CYBA Gene and the Risk of Coronary Artery Disease: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 9(1), pages 1-8, January.
    14. Hoehun Ha & Wei Tu, 2018. "An Ecological Study on the Spatially Varying Relationship between County-Level Suicide Rates and Altitude in the United States," IJERPH, MDPI, vol. 15(4), pages 1-16, April.
    15. Eduardo Martínez-Martínez & María Luisa Zaragoza & Elmer Solano & Brenda Figueroa & Patricia Zúñiga & Juan P Laclette, 2012. "Health Research Funding in Mexico: The Need for a Long-Term Agenda," PLOS ONE, Public Library of Science, vol. 7(12), pages 1-11, December.
    16. Zarish Noreen & Christopher A. Loffredo & Attya Bhatti & Jyothirmai J. Simhadri & Gail Nunlee-Bland & Thomas Nnanabu & Peter John & Jahangir S. Khan & Somiranjan Ghosh, 2020. "Transcriptional Profiling and Biological Pathway(s) Analysis of Type 2 Diabetes Mellitus in a Pakistani Population," IJERPH, MDPI, vol. 17(16), pages 1-20, August.
    17. Ian M. McCarthy, 2015. "Putting the Patient in Patient Reported Outcomes: A Robust Methodology for Health Outcomes Assessment," Health Economics, John Wiley & Sons, Ltd., vol. 24(12), pages 1588-1603, December.
    18. Joern Birkmann & Susan Cutter & Dale Rothman & Torsten Welle & Matthias Garschagen & Bas Ruijven & Brian O’Neill & Benjamin Preston & Stefan Kienberger & Omar Cardona & Tiodora Siagian & Deny Hidayati, 2015. "Scenarios for vulnerability: opportunities and constraints in the context of climate change and disaster risk," Climatic Change, Springer, vol. 133(1), pages 53-68, November.
    19. Kimberley E Wever & Carlijn R Hooijmans & Niels P Riksen & Thomas B Sterenborg & Emily S Sena & Merel Ritskes-Hoitinga & Michiel C Warlé, 2015. "Determinants of the Efficacy of Cardiac Ischemic Preconditioning: A Systematic Review and Meta-Analysis of Animal Studies," PLOS ONE, Public Library of Science, vol. 10(11), pages 1-17, November.
    20. Junyan Teng & Yanping Wei & Fengming Su & Zhiping Guo & Jing-Quan Zhong, 2015. "Evaluating of Physiological Chemical Levels in Blood to Assess the Risk of Morbidity and Mortality of Ischemic Cardiovascular Disease," IJERPH, MDPI, vol. 12(9), pages 1-11, September.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0070588. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.