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Meta-Analysis: Melatonin for the Treatment of Primary Sleep Disorders

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  • Eduardo Ferracioli-Oda
  • Ahmad Qawasmi
  • Michael H Bloch

Abstract

Study Objectives: To investigate the efficacy of melatonin compared to placebo in improving sleep parameters in patients with primary sleep disorders. Design: PubMed was searched for randomized, placebo-controlled trials examining the effects of melatonin for the treatment of primary sleep disorders. Primary outcomes examined were improvement in sleep latency, sleep quality and total sleep time. Meta-regression was performed to examine the influence of dose and duration of melatonin on reported efficacy. Participants: Adults and children diagnosed with primary sleep disorders. Interventions: Melatonin compared to placebo. Results: Nineteen studies involving 1683 subjects were included in this meta-analysis. Melatonin demonstrated significant efficacy in reducing sleep latency (weighted mean difference (WMD) = 7.06 minutes [95% CI 4.37 to 9.75], Z = 5.15, p

Suggested Citation

  • Eduardo Ferracioli-Oda & Ahmad Qawasmi & Michael H Bloch, 2013. "Meta-Analysis: Melatonin for the Treatment of Primary Sleep Disorders," PLOS ONE, Public Library of Science, vol. 8(5), pages 1-6, May.
    • Handle: RePEc:plo:pone00:0063773
    DOI: 10.1371/journal.pone.0063773
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    Cited by:

    1. Bárbara Carriedo-Diez & Javier Lucas Tosoratto-Venturi & Carmen Cantón-Manzano & Carmina Wanden-Berghe & Javier Sanz-Valero, 2022. "The Effects of the Exogenous Melatonin on Shift Work Sleep Disorder in Health Personnel: A Systematic Review," IJERPH, MDPI, vol. 19(16), pages 1-19, August.
    2. Beatrice Ragnoli & Patrizia Pochetti & Alberto Raie & Mario Malerba, 2021. "Comorbid Insomnia and Obstructive Sleep Apnea (COMISA): Current Concepts of Patient Management," IJERPH, MDPI, vol. 18(17), pages 1-15, September.
    3. Kyeongmin Kwak & Bong-Kyu Kim & Tae-Won Jang & Chang Sun Sim & Yeon-Soon Ahn & Kyeong-Sook Choi & Kyoung Sook Jeong, 2020. "Association between Shift Work and Neurocognitive Function among Firefighters in South Korea: A Prospective before–after Study," IJERPH, MDPI, vol. 17(13), pages 1-15, June.
    4. Yonghwan Kim & Hee-Taik Kang & Duk-Chul Lee, 2021. "Melatonin Supplementation for Six Weeks Had No Effect on Arterial Stiffness and Mitochondrial DNA in Women Aged 55 Years and Older with Insomnia: A Double-Blind Randomized Controlled Study," IJERPH, MDPI, vol. 18(5), pages 1-10, March.

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