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The Effects of the Exogenous Melatonin on Shift Work Sleep Disorder in Health Personnel: A Systematic Review

Author

Listed:
  • Bárbara Carriedo-Diez

    (Manacor Hospital, Occupational Health Service, 07500 Manacor, Spain)

  • Javier Lucas Tosoratto-Venturi

    (Son Llàtzer Hospital, Occupational Health Service, 07198 Palma, Spain)

  • Carmen Cantón-Manzano

    (Getafe Hospital, Occupational Risk Prevention Service, 28905 Getafe, Spain)

  • Carmina Wanden-Berghe

    (Foundation for the Promotion of Health and Biomedical Research in the Valencian Region (FISABIO), Health and Biomedical Research Institute of Alicante (ISABIAL), 03010 Alicante, Spain)

  • Javier Sanz-Valero

    (Department of Public Health and History of Science, Miguel Hernández University, 03550 Alicante, Spain
    Carlos III Health Institute, National School of Occupational Medicine, 37311 Madrid, Spain)

Abstract

(1) Background: To know the medical documentation related to exogenous melatonin in sleep disorders caused by shift work in health personnel; (2) Methods: Systematic and critical review. Data were obtained by looking up the bibliographic data base: MEDLINE (via Pubmed), Embase, Cochrane Library, Scopus, Web of Science, Latin American and Caribbean literature in Health Sciences (LILACS) and Medicine in Spanish (MEDES). The used terms, as descriptors and text in the title and abstract record fields, were “Health Personnel”, “Melatonin” and “Sleep Disorders”, Circadian Rhythm, by using the following filters: “Humans”, “Adult: 19+ years” and “Clinical Trial”. The search update was in December 2021. The documentary quality of the articles was assessed using the CONSORT questionnaire. (3) Results: Having applied the inclusion and exclusion criteria, 10 clinical essays were selected out of 98 retrieved references. CONSORT scores ranged from a minimum of 6.0 to a maximum of 13. 7 with a median of 10.2. According to the SIGN criteria, this review presented “1-“evidence with a grade of recommendation B. The intervention dose via administration of exogenous melatonin ranged between 1 and 10 mg. It was not mentioned whether the route of administration was by fast or slow absorption. The outcomes showed decreased daytime sleepiness, lessened sleep onset latency, diminished night-time awakenings, increased total sleep period and improved daytime attention in the melatonin-treated group; (4) Conclusions: Exogenously administered melatonin is effective in shift worker health personnel that are suffering from sleep disorders, and given its low adverse effects and tolerability, it might be recommended. A great disparity was evidenced in terms of dose, follow-up periods and type of melatonin, small participant population, same age ranges and young age. Therefore, new trials would be needed to amend these observations in order to have full evidence that is able to ensure the efficacy of exogenous melatonin in the studied population.

Suggested Citation

  • Bárbara Carriedo-Diez & Javier Lucas Tosoratto-Venturi & Carmen Cantón-Manzano & Carmina Wanden-Berghe & Javier Sanz-Valero, 2022. "The Effects of the Exogenous Melatonin on Shift Work Sleep Disorder in Health Personnel: A Systematic Review," IJERPH, MDPI, vol. 19(16), pages 1-19, August.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:16:p:10199-:d:890385
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    References listed on IDEAS

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    1. Eduardo Ferracioli-Oda & Ahmad Qawasmi & Michael H Bloch, 2013. "Meta-Analysis: Melatonin for the Treatment of Primary Sleep Disorders," PLOS ONE, Public Library of Science, vol. 8(5), pages 1-6, May.
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