IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0060516.html
   My bibliography  Save this article

Decreased Expression of Beclin 1 Correlates Closely with Bcl-xL Expression and Poor Prognosis of Ovarian Carcinoma

Author

Listed:
  • Huan-Xin Lin
  • Hui-Juan Qiu
  • Fei Zeng
  • Hui-Lan Rao
  • Guo-Fen Yang
  • Hsiang-Fu Kung
  • Xiao-Feng Zhu
  • Yi-Xin Zeng
  • Mu-Yan Cai
  • Dan Xie

Abstract

Background: It has been suggested that autophagy-related Beclin 1 plays a critical role in the regulation of tumor development and/or progression, but its prognostic significance and relationship with Bcl-xL expression in ovarian carcinoma are unclear. Methodology/Principal Findings: In the present study, the methods of Western blotting and immunohistochemistry (IHC) were utilized to investigate the expression status of Beclin 1 and Bcl-xL in fresh ovarian tissues and paraffin-embedded epithelial ovarian tumor tissues. Decreased expression of Beclin 1 was examined by IHC in 8.3% of normal ovaries, in 15.4% of cystadenomas, in 20.0% of borderline tumors, and in 55.6% of ovarian carcinomas, respectively. In ovarian carcinomas, decreased expression of Beclin 1 was correlated closely with ascending histological grade, later pT/pN/pM status and/or advanced clinical stage (P

Suggested Citation

  • Huan-Xin Lin & Hui-Juan Qiu & Fei Zeng & Hui-Lan Rao & Guo-Fen Yang & Hsiang-Fu Kung & Xiao-Feng Zhu & Yi-Xin Zeng & Mu-Yan Cai & Dan Xie, 2013. "Decreased Expression of Beclin 1 Correlates Closely with Bcl-xL Expression and Poor Prognosis of Ovarian Carcinoma," PLOS ONE, Public Library of Science, vol. 8(4), pages 1-10, April.
    • Handle: RePEc:plo:pone00:0060516
    DOI: 10.1371/journal.pone.0060516
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0060516
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0060516&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0060516?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Gian Maria Fimia & Anastassia Stoykova & Alessandra Romagnoli & Luigi Giunta & Sabrina Di Bartolomeo & Roberta Nardacci & Marco Corazzari & Claudia Fuoco & Ahmet Ucar & Peter Schwartz & Peter Gruss & , 2007. "Ambra1 regulates autophagy and development of the nervous system," Nature, Nature, vol. 447(7148), pages 1121-1125, June.
    2. Xiao Huan Liang & Saadiya Jackson & Matthew Seaman & Kristy Brown & Bettina Kempkes & Hanina Hibshoosh & Beth Levine, 1999. "Induction of autophagy and inhibition of tumorigenesis by beclin 1," Nature, Nature, vol. 402(6762), pages 672-676, December.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Yaechan Song & Heeju Na & Seung Eon Lee & You Min Kim & Jihyun Moon & Tae Wook Nam & Yul Ji & Young Jin & Jae Hyung Park & Seok Chan Cho & Jaehoon Lee & Daehee Hwang & Sang-Jun Ha & Hyun Woo Park & Ja, 2024. "Dysfunctional adipocytes promote tumor progression through YAP/TAZ-dependent cancer-associated adipocyte transformation," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    2. Jing-Lan Liu & Fen-Fen Chen & Shun-Fu Chang & Cheng-Nan Chen & Jrhau Lung & Cheng-Hsing Lo & Fang-Hui Lee & Ying-Chou Lu & Chien-Hui Hung, 2015. "Expression of Beclin Family Proteins Is Associated with Tumor Progression in Oral Cancer," PLOS ONE, Public Library of Science, vol. 10(10), pages 1-18, October.
    3. Ming Liu & Yang Wang & Fei Teng & Xinyi Mai & Xi Wang & Ming-Yuan Su & Goran Stjepanovic, 2023. "Structure of the DDB1-AMBRA1 E3 ligase receptor complex linked to cell cycle regulation," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    4. Ida Barca & Chiara Mignogna & Daniela Novembre & Francesco Ferragina & Maria Giulia Cristofaro, 2021. "Immunohistochemical Analysis of the Beclin-1 Expression Predicts the Progression of Oral Squamous Cell Carcinoma," IJERPH, MDPI, vol. 18(21), pages 1-8, October.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0060516. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.