IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v447y2007i7148d10.1038_nature05925.html
   My bibliography  Save this article

Ambra1 regulates autophagy and development of the nervous system

Author

Listed:
  • Gian Maria Fimia

    (National Institute for Infectious Diseases IRCCS ‘L. Spallanzani’, 00149 Rome, Italy)

  • Anastassia Stoykova

    (Max Planck Institute of Biophysical Chemistry, 37077 Göttingen, Germany)

  • Alessandra Romagnoli

    (National Institute for Infectious Diseases IRCCS ‘L. Spallanzani’, 00149 Rome, Italy)

  • Luigi Giunta

    (Dulbecco Telethon Institute at the Department of Biology,
    Laboratory of Molecular Neuroembryology, IRCCS Fondazione Santa Lucia, 00143 Rome, Italy)

  • Sabrina Di Bartolomeo

    (Dulbecco Telethon Institute at the Department of Biology,
    Laboratory of Molecular Neuroembryology, IRCCS Fondazione Santa Lucia, 00143 Rome, Italy)

  • Roberta Nardacci

    (National Institute for Infectious Diseases IRCCS ‘L. Spallanzani’, 00149 Rome, Italy)

  • Marco Corazzari

    (National Institute for Infectious Diseases IRCCS ‘L. Spallanzani’, 00149 Rome, Italy)

  • Claudia Fuoco

    (Dulbecco Telethon Institute at the Department of Biology,
    Laboratory of Molecular Neuroembryology, IRCCS Fondazione Santa Lucia, 00143 Rome, Italy)

  • Ahmet Ucar

    (Max Planck Institute of Biophysical Chemistry, 37077 Göttingen, Germany)

  • Peter Schwartz

    (University of Göttingen, 37085 Göttingen, Germany)

  • Peter Gruss

    (Max Planck Institute of Biophysical Chemistry, 37077 Göttingen, Germany)

  • Mauro Piacentini

    (National Institute for Infectious Diseases IRCCS ‘L. Spallanzani’, 00149 Rome, Italy
    University of Rome ‘Tor Vergata’, 00133 Rome, Italy)

  • Kamal Chowdhury

    (Max Planck Institute of Biophysical Chemistry, 37077 Göttingen, Germany)

  • Francesco Cecconi

    (Dulbecco Telethon Institute at the Department of Biology,
    Laboratory of Molecular Neuroembryology, IRCCS Fondazione Santa Lucia, 00143 Rome, Italy)

Abstract

The identification of the large protein Ambra-1, which regulates autophagy and plays a crucial role in embryogenesis is described. The absence of Ambra-1 function during development results in severe neural tube defects associated with autophagy impairment, accumulation of ubiquitinated proteins, unbalanced cell proliferation and excessive apoptotic cell death.

Suggested Citation

  • Gian Maria Fimia & Anastassia Stoykova & Alessandra Romagnoli & Luigi Giunta & Sabrina Di Bartolomeo & Roberta Nardacci & Marco Corazzari & Claudia Fuoco & Ahmet Ucar & Peter Schwartz & Peter Gruss & , 2007. "Ambra1 regulates autophagy and development of the nervous system," Nature, Nature, vol. 447(7148), pages 1121-1125, June.
    • Handle: RePEc:nat:nature:v:447:y:2007:i:7148:d:10.1038_nature05925
    DOI: 10.1038/nature05925
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature05925
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature05925?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Ming Liu & Yang Wang & Fei Teng & Xinyi Mai & Xi Wang & Ming-Yuan Su & Goran Stjepanovic, 2023. "Structure of the DDB1-AMBRA1 E3 ligase receptor complex linked to cell cycle regulation," Nature Communications, Nature, vol. 14(1), pages 1-12, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:447:y:2007:i:7148:d:10.1038_nature05925. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.