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Elevated Soluble Triggering Receptor Expressed on Myeloid Cells (sTREM)-1 Levels in Maternal Serum during Term and Preterm Labor

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Listed:
  • Inge Tency
  • Hans Verstraelen
  • Bart Saerens
  • Bruno Verhasselt
  • Mario Vaneechoutte
  • Olivier Degomme
  • Rita Verhelst
  • Marleen Temmerman

Abstract

Background: Infection and inflammation are important mechanisms leading to preterm birth. Soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) belongs to a family of cell surface receptors that seems to play an important role in fine-tuning the immune response. It has been demonstrated that sTREM-1 is involved in bacterial infection as well as in non-infectious inflammatory conditions. Few studies have investigated serum sTREM-1 expression during preterm labor. Therefore, the purpose of this study was to assess sTREM-1 concentrations in maternal serum during term and preterm labor. Methods: This case control study included 176 singleton pregnancies in the following groups: patients in (1) preterm labor, delivered before 34 weeks (PTB) (n = 52); (2) GA matched controls, not in labor, matched for gestational age (GA) with the PTB group (n = 52); (3) at term in labor (n = 40) and (4) at term not in labor (n = 32). sTREM-1 concentrations were determined by enzyme-linked immunoassay. Results: sTREM-1 was detected in all serum samples. Median sTREM-1 concentrations were significantly higher in women with PTB vs. GA matched controls (367 pg/ml, interquartile range (IQR) 304–483 vs. 273 pg/ml, IQR 208–334; P

Suggested Citation

  • Inge Tency & Hans Verstraelen & Bart Saerens & Bruno Verhasselt & Mario Vaneechoutte & Olivier Degomme & Rita Verhelst & Marleen Temmerman, 2013. "Elevated Soluble Triggering Receptor Expressed on Myeloid Cells (sTREM)-1 Levels in Maternal Serum during Term and Preterm Labor," PLOS ONE, Public Library of Science, vol. 8(2), pages 1-7, February.
    • Handle: RePEc:plo:pone00:0056050
    DOI: 10.1371/journal.pone.0056050
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    References listed on IDEAS

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    1. Axel Bouchon & Fabio Facchetti & Markus A. Weigand & Marco Colonna, 2001. "TREM-1 amplifies inflammation and is a crucial mediator of septic shock," Nature, Nature, vol. 410(6832), pages 1103-1107, April.
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