IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v410y2001i6832d10.1038_35074114.html
   My bibliography  Save this article

TREM-1 amplifies inflammation and is a crucial mediator of septic shock

Author

Listed:
  • Axel Bouchon

    (Basel Institute for Immunology)

  • Fabio Facchetti

    (Institute of Pathology, University of Brescia, Spedali Civili 1)

  • Markus A. Weigand

    (Clinic of Anaesthesiology, University of Heidelberg and Tumor Immunology Program, German Cancer Research Institute, (DKFZ), INF 110,280)

  • Marco Colonna

    (Basel Institute for Immunology)

Abstract

Host innate responses to bacterial infections are primarily mediated by neutrophils and monocytes/macrophages1,2. These cells express pattern recognition receptors (PRRs) that bind conserved molecular structures shared by groups of microorganisms3,4. Stimulation of PRR signalling pathways initiates secretion of proinflammatory mediators3,4, which promote the elimination of infectious agents and the induction of tissue repair. Excessive inflammation owing to bacterial infections can lead to tissue damage and septic shock5,6,7,8,9. Here we show that inflammatory responses to microbial products are amplified by a pathway mediated by triggering receptor expressed on myeloid cells (TREM)-1. TREM-1 is an activating receptor expressed at high levels on neutrophils and monocytes that infiltrate human tissues infected with bacteria. Furthermore, it is upregulated on peritoneal neutrophils of patients with microbial sepsis and mice with experimental lipopolysaccaride (LPS)-induced shock. Notably, blockade of TREM-1 protects mice against LPS-induced shock, as well as microbial sepsis caused by live Escherichia coli or caecal ligation and puncture. These results demonstrate a critical function of TREM-1 in acute inflammatory responses to bacteria and implicate TREM-1 as a potential therapeutic target for septic shock.

Suggested Citation

  • Axel Bouchon & Fabio Facchetti & Markus A. Weigand & Marco Colonna, 2001. "TREM-1 amplifies inflammation and is a crucial mediator of septic shock," Nature, Nature, vol. 410(6832), pages 1103-1107, April.
    • Handle: RePEc:nat:nature:v:410:y:2001:i:6832:d:10.1038_35074114
    DOI: 10.1038/35074114
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/35074114
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/35074114?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Katharina Walter & Henning Grosskopf & Isabel Karkossa & Martin von Bergen & Kristin Schubert, 2021. "Proteomic Characterization of the Cellular Effects of AhR Activation by Microbial Tryptophan Catabolites in Endotoxin-Activated Human Macrophages," IJERPH, MDPI, vol. 18(19), pages 1-18, September.
    2. Mathieu Barbier & Dorothée Faille & Béatrice Loriod & Julien Textoris & Claire Camus & Denis Puthier & Laurence Flori & Samuel Crocodile Wassmer & Geneviève Victorero & Marie-Christine Alessi & Thierr, 2011. "Platelets Alter Gene Expression Profile in Human Brain Endothelial Cells in an In Vitro Model of Cerebral Malaria," PLOS ONE, Public Library of Science, vol. 6(5), pages 1-14, May.
    3. Inge Tency & Hans Verstraelen & Bart Saerens & Bruno Verhasselt & Mario Vaneechoutte & Olivier Degomme & Rita Verhelst & Marleen Temmerman, 2013. "Elevated Soluble Triggering Receptor Expressed on Myeloid Cells (sTREM)-1 Levels in Maternal Serum during Term and Preterm Labor," PLOS ONE, Public Library of Science, vol. 8(2), pages 1-7, February.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:410:y:2001:i:6832:d:10.1038_35074114. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.