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Performance of Different Gastric Cancer Screening Methods in Korea: A Population-Based Study

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  • Kui Son Choi
  • Jae Kwan Jun
  • Eun-Cheol Park
  • Sohee Park
  • Kyu Won Jung
  • Mi Ah Han
  • Il Ju Choi
  • Hoo-Yeon Lee

Abstract

Background: There is a lack of agreement on which gastric cancer screening method is the most effective in the general population. The present study compared the relative performance of upper-gastrointestinal series (UGIS) and endoscopy screening for gastric cancer. Methods: A population-based study was conducted using the National Cancer Screening Program (NCSP) database. We analyzed data on 2,690,731 men and women in Korea who underwent either UGIS or endoscopy screening for gastric cancer between January 1, 2002 and December 31, 2005. Final gastric cancer diagnosis was ascertained through linkage with the Korean Central Cancer Registry. We calculated positivity rate, gastric cancer detection rate, interval cancer rate, sensitivity, specificity, and positive predictive value of UGIS and endoscopy screening. Results: The positivity rates for UGIS and endoscopy screening were 39.7 and 42.1 per 1,000 screenings, respectively. Gastric cancer detection rates were 0.68 and 2.61 per 1,000 screenings, respectively. In total, 2,067 interval cancers occurred within 1 year of a negative UGIS screening result (rate, 1.17/1,000) and 1,083 after a negative endoscopy screening result (rate, 1.17/1,000). The sensitivity of UGIS and endoscopy screening to detect gastric cancer was 36.7 and 69.0%, respectively, and specificity was 96.1 and 96.0%. The sensitivity of endoscopy screening to detect localized gastric cancer was 65.7%, which was statistically significantly higher than that of UGIS screening. Conclusion: Overall, endoscopy performed better than UGIS in the NCSP for gastric cancer. Further evaluation of the impact of these screening methods should take into account the corresponding costs and reduction in mortality.

Suggested Citation

  • Kui Son Choi & Jae Kwan Jun & Eun-Cheol Park & Sohee Park & Kyu Won Jung & Mi Ah Han & Il Ju Choi & Hoo-Yeon Lee, 2012. "Performance of Different Gastric Cancer Screening Methods in Korea: A Population-Based Study," PLOS ONE, Public Library of Science, vol. 7(11), pages 1-8, November.
    • Handle: RePEc:plo:pone00:0050041
    DOI: 10.1371/journal.pone.0050041
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    Cited by:

    1. Ming-ming He & Wen-jing Wu & Feng Wang & Zhi-qiang Wang & Dong-sheng Zhang & Hui-yan Luo & Miao-zhen Qiu & Feng-hua Wang & Chao Ren & Zhao-lei Zeng & Rui-hua Xu, 2013. "S-1-Based Chemotherapy versus Capecitabine-Based Chemotherapy as First-Line Treatment for Advanced Gastric Carcinoma: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(12), pages 1-1, December.
    2. Clara Benedetta Conti & Stefano Agnesi & Miki Scaravaglio & Pietro Masseria & Marco Emilio Dinelli & Massimo Oldani & Fabio Uggeri, 2023. "Early Gastric Cancer: Update on Prevention, Diagnosis and Treatment," IJERPH, MDPI, vol. 20(3), pages 1-21, January.
    3. Jung, Minsoo, 2015. "National Cancer Screening Programs and Evidence-Based Healthcare Policy in South Korea," Health Policy, Elsevier, vol. 119(1), pages 26-32.
    4. Chisato Hamashima & Michiko Shabana & Mikizo Okamoto & Yoneatsu Osaki & Takuji Kishimoto, 2015. "Survival Analysis of Patients with Interval Cancer Undergoing Gastric Cancer Screening by Endoscopy," PLOS ONE, Public Library of Science, vol. 10(5), pages 1-15, May.
    5. Rachel Farber & Nehmat Houssami & Isabelle Barnes & Kevin McGeechan & Alexandra Barratt & Katy J. L. Bell, 2022. "Considerations for Evaluating the Introduction of New Cancer Screening Technology: Use of Interval Cancers to Assess Potential Benefits and Harms," IJERPH, MDPI, vol. 19(22), pages 1-17, November.

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