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Role of IKK/NF-κB Signaling in Extinction of Conditioned Place Aversion Memory in Rats

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  • Cheng-Hao Yang
  • Xiang-Ming Liu
  • Ji-Jian Si
  • Hai-Shui Shi
  • Yan-Xue Xue
  • Jian-Feng Liu
  • Yi-Xiao Luo
  • Chen Chen
  • Peng Li
  • Jian-Li Yang
  • Ping Wu
  • Lin Lu

Abstract

The inhibitor κB protein kinase/nuclear factor κB (IKK/NF-κB) signaling pathway is critical for synaptic plasticity. However, the role of IKK/NF-κB in drug withdrawal-associated conditioned place aversion (CPA) memory is unknown. Here, we showed that inhibition of IKK/NF-κB by sulphasalazine (SSZ; 10 mM, i.c.v.) selectively blocked the extinction but not acquisition or expression of morphine-induced CPA in rats. The blockade of CPA extinction induced by SSZ was abolished by sodium butyrate, an inhibitor of histone deacetylase. Thus, the IKK/NF-κB signaling pathway might play a critical role in the extinction of morphine-induced CPA in rats and might be a potential pharmacotherapy target for opiate addiction.

Suggested Citation

  • Cheng-Hao Yang & Xiang-Ming Liu & Ji-Jian Si & Hai-Shui Shi & Yan-Xue Xue & Jian-Feng Liu & Yi-Xiao Luo & Chen Chen & Peng Li & Jian-Li Yang & Ping Wu & Lin Lu, 2012. "Role of IKK/NF-κB Signaling in Extinction of Conditioned Place Aversion Memory in Rats," PLOS ONE, Public Library of Science, vol. 7(6), pages 1-8, June.
    • Handle: RePEc:plo:pone00:0039696
    DOI: 10.1371/journal.pone.0039696
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    References listed on IDEAS

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    1. Mohammed R. Milad & Gregory J. Quirk, 2002. "Neurons in medial prefrontal cortex signal memory for fear extinction," Nature, Nature, vol. 420(6911), pages 70-74, November.
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