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Conflict of Interest Policies for Organizations Producing a Large Number of Clinical Practice Guidelines

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  • Susan L Norris
  • Haley K Holmer
  • Brittany U Burda
  • Lauren A Ogden
  • Rongwei Fu

Abstract

Background: Conflict of interest (COI) of clinical practice guideline (CPG) sponsors and authors is an important potential source of bias in CPG development. The objectives of this study were to describe the COI policies for organizations currently producing a significant number of CPGs, and to determine if these policies meet 2011 Institute of Medicine (IOM) standards. Methodology/Principal Findings: We identified organizations with five or more guidelines listed in the National Guideline Clearinghouse between January 1, 2009 and November 5, 2010. We obtained the COI policy for each organization from publicly accessible sources, most often the organization's website, and compared those polices to IOM standards related to COI. 37 organizations fulfilled our inclusion criteria, of which 17 (46%) had a COI policy directly related to CPGs. These COI policies varied widely with respect to types of COI addressed, from whom disclosures were collected, monetary thresholds for disclosure, approaches to management, and updating requirements. Not one organization's policy adhered to all seven of the IOM standards that were examined, and nine organizations did not meet a single one of the standards. Conclusions/Significance: COI policies among organizations producing a large number of CPGs currently do not measure up to IOM standards related to COI disclosure and management. CPG developers need to make significant improvements in these policies and their implementation in order to optimize the quality and credibility of their guidelines.

Suggested Citation

  • Susan L Norris & Haley K Holmer & Brittany U Burda & Lauren A Ogden & Rongwei Fu, 2012. "Conflict of Interest Policies for Organizations Producing a Large Number of Clinical Practice Guidelines," PLOS ONE, Public Library of Science, vol. 7(5), pages 1-12, May.
    • Handle: RePEc:plo:pone00:0037413
    DOI: 10.1371/journal.pone.0037413
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    References listed on IDEAS

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    1. Rosie Taylor & Jim Giles, 2005. "Cash interests taint drug advice," Nature, Nature, vol. 437(7062), pages 1070-1071, October.
    2. Susan L Norris & Haley K Holmer & Lauren A Ogden & Brittany U Burda, 2011. "Conflict of Interest in Clinical Practice Guideline Development: A Systematic Review," PLOS ONE, Public Library of Science, vol. 6(10), pages 1-6, October.
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    1. Tanya Graham & Phil Alderson & Tim Stokes, 2015. "Managing Conflicts of Interest in the UK National Institute for Health and Care Excellence (NICE) Clinical Guidelines Programme: Qualitative Study," PLOS ONE, Public Library of Science, vol. 10(3), pages 1-10, March.
    2. Rachel Thompson & Zoe Paskins & Barry G. Main & Thaddeus Mason Pope & Evelyn C. Y. Chan & Ben W. Moulton & Michael J. Barry & Clarence H. Braddock III, 2021. "Addressing Conflicts of Interest in Health and Medicine: Current Evidence and Implications for Patient Decision Aid Development," Medical Decision Making, , vol. 41(7), pages 768-779, October.
    3. Chase Meyer & Aaron Bowers & Cole Wayant & Jake Checketts & Jared Scott & Sanjeev Musuvathy & Matt Vassar, 2018. "Scientific evidence underlying the American College of Gastroenterology’s clinical practice guidelines," PLOS ONE, Public Library of Science, vol. 13(10), pages 1-9, October.
    4. Cristina Morciano & Vittorio Basevi & Carla Faralli & Michele Hilton Boon & Sabina Tonon & Domenica Taruscio, 2016. "Policies on Conflicts of Interest in Health Care Guideline Development: A Cross-Sectional Analysis," PLOS ONE, Public Library of Science, vol. 11(11), pages 1-24, November.
    5. Susan L Norris & Haley K Holmer & Lauren A Ogden & Shelley S Selph & Rongwei Fu, 2012. "Conflict of Interest Disclosures for Clinical Practice Guidelines in the National Guideline Clearinghouse," PLOS ONE, Public Library of Science, vol. 7(11), pages 1-8, November.

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