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Association of Common Variants in TNFRSF13B, TNFSF13, and ANXA3 with Serum Levels of Non-Albumin Protein and Immunoglobulin Isotypes in Japanese

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  • Wael Osman
  • Yukinori Okada
  • Yoichiro Kamatani
  • Michiaki Kubo
  • Koichi Matsuda
  • Yusuke Nakamura

Abstract

We performed a genome-wide association study (GWAS) on levels of serum total protein (TP), albumin (ALB), and non-albumin protein (NAP). We analyzed SNPs on autosomal chromosomes using data from 9,103 Japanese individuals, followed by a replication study of 1,600 additional individuals. We confirmed the previously- reported association of GCKR on chromosome 2p23.3 with serum ALB (rs1260326, Pmeta = 3.1×10−9), and additionally identified the significant genome-wide association of rs4985726 in TNFRSF13B on 17p11.2 with both TP and NAP (Pmeta = 1.2×10−14 and 7.1×10−24, respectively). For NAP, rs3803800 and rs11552708 in TNFSF13 on 17p13.1 (Pmeta = 7.2×10−15 and 7.5×10−10, respectively) as well as rs10007186 on 4q21.2 near ANXA3 (Pmeta = 1.3×10−9) also indicated significant associations. Interestingly, TNFRSF13B and TNFSF13 encode a tumor necrosis factor (TNF) receptor and its ligand, which together constitute an important receptor-ligand axis for B-cell homeostasis and immunoglobulin production. Furthermore, three SNPs, rs4985726, rs3803800, and rs11552708 in TNFRSF13B and TNFSF13, were indicated to be associated with serum levels of IgG (P

Suggested Citation

  • Wael Osman & Yukinori Okada & Yoichiro Kamatani & Michiaki Kubo & Koichi Matsuda & Yusuke Nakamura, 2012. "Association of Common Variants in TNFRSF13B, TNFSF13, and ANXA3 with Serum Levels of Non-Albumin Protein and Immunoglobulin Isotypes in Japanese," PLOS ONE, Public Library of Science, vol. 7(4), pages 1-7, April.
    • Handle: RePEc:plo:pone00:0032683
    DOI: 10.1371/journal.pone.0032683
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    1. Melanie Kolz & Toby Johnson & Serena Sanna & Alexander Teumer & Veronique Vitart & Markus Perola & Massimo Mangino & Eva Albrecht & Chris Wallace & Martin Farrall & Åsa Johansson & Dale R Nyholt & Yur, 2009. "Meta-Analysis of 28,141 Individuals Identifies Common Variants within Five New Loci That Influence Uric Acid Concentrations," PLOS Genetics, Public Library of Science, vol. 5(6), pages 1-10, June.
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