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Simulation and Mechanistic Investigation of the Arrhythmogenic Role of the Late Sodium Current in Human Heart Failure

Author

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  • Beatriz Trenor
  • Karen Cardona
  • Juan F Gomez
  • Sridharan Rajamani
  • Jose M Ferrero Jr
  • Luiz Belardinelli
  • Javier Saiz

Abstract

Heart failure constitutes a major public health problem worldwide. The electrophysiological remodeling of failing hearts sets the stage for malignant arrhythmias, in which the role of the late Na+ current (INaL) is relevant and is currently under investigation. In this study we examined the role of INaL in the electrophysiological phenotype of ventricular myocytes, and its proarrhythmic effects in the failing heart. A model for cellular heart failure was proposed using a modified version of Grandi et al. model for human ventricular action potential that incorporates the formulation of INaL. A sensitivity analysis of the model was performed and simulations of the pathological electrical activity of the cell were conducted. The proposed model for the human INaL and the electrophysiological remodeling of myocytes from failing hearts accurately reproduce experimental observations. The sensitivity analysis of the modulation of electrophysiological parameters of myocytes from failing hearts due to ion channels remodeling, revealed a role for INaL in the prolongation of action potential duration (APD), triangulation of the shape of the AP, and changes in Ca2+ transient. A mechanistic investigation of intracellular Na+ accumulation and APD shortening with increasing frequency of stimulation of failing myocytes revealed a role for the Na+/K+ pump, the Na+/Ca2+ exchanger and INaL. The results of the simulations also showed that in failing myocytes, the enhancement of INaL increased the reverse rate-dependent APD prolongation and the probability of initiating early afterdepolarizations. The electrophysiological remodeling of failing hearts and especially the enhancement of the INaL prolong APD and alter Ca2+ transient facilitating the development of early afterdepolarizations. An enhanced INaL appears to be an important contributor to the electrophysiological phenotype and to the dysregulation of [Ca2+]i homeostasis of failing myocytes.

Suggested Citation

  • Beatriz Trenor & Karen Cardona & Juan F Gomez & Sridharan Rajamani & Jose M Ferrero Jr & Luiz Belardinelli & Javier Saiz, 2012. "Simulation and Mechanistic Investigation of the Arrhythmogenic Role of the Late Sodium Current in Human Heart Failure," PLOS ONE, Public Library of Science, vol. 7(3), pages 1-13, March.
    • Handle: RePEc:plo:pone00:0032659
    DOI: 10.1371/journal.pone.0032659
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    1. Thomas O'Hara & László Virág & András Varró & Yoram Rudy, 2011. "Simulation of the Undiseased Human Cardiac Ventricular Action Potential: Model Formulation and Experimental Validation," PLOS Computational Biology, Public Library of Science, vol. 7(5), pages 1-29, May.
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