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MicroRNA Expression in Abdominal and Gluteal Adipose Tissue Is Associated with mRNA Expression Levels and Partly Genetically Driven

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Listed:
  • Mattias Rantalainen
  • Blanca M Herrera
  • George Nicholson
  • Rory Bowden
  • Quin F Wills
  • Josine L Min
  • Matt J Neville
  • Amy Barrett
  • Maxine Allen
  • Nigel W Rayner
  • Jan Fleckner
  • Mark I McCarthy
  • Krina T Zondervan
  • Fredrik Karpe
  • Chris C Holmes
  • Cecilia M Lindgren

Abstract

To understand how miRNAs contribute to the molecular phenotype of adipose tissues and related traits, we performed global miRNA expression profiling in subcutaneous abdominal and gluteal adipose tissue of 70 human subjects and characterised which miRNAs were differentially expressed between these tissues. We found that 12% of the miRNAs were significantly differentially expressed between abdominal and gluteal adipose tissue (FDR adjusted p

Suggested Citation

  • Mattias Rantalainen & Blanca M Herrera & George Nicholson & Rory Bowden & Quin F Wills & Josine L Min & Matt J Neville & Amy Barrett & Maxine Allen & Nigel W Rayner & Jan Fleckner & Mark I McCarthy & , 2011. "MicroRNA Expression in Abdominal and Gluteal Adipose Tissue Is Associated with mRNA Expression Levels and Partly Genetically Driven," PLOS ONE, Public Library of Science, vol. 6(11), pages 1-12, November.
    • Handle: RePEc:plo:pone00:0027338
    DOI: 10.1371/journal.pone.0027338
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    References listed on IDEAS

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    1. Huili Guo & Nicholas T. Ingolia & Jonathan S. Weissman & David P. Bartel, 2010. "Mammalian microRNAs predominantly act to decrease target mRNA levels," Nature, Nature, vol. 466(7308), pages 835-840, August.
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