IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0024987.html
   My bibliography  Save this article

Functional Polymorphisms in the TERT Promoter Are Associated with Risk of Serous Epithelial Ovarian and Breast Cancers

Author

Listed:
  • Jonathan Beesley
  • Hilda A Pickett
  • Sharon E Johnatty
  • Alison M Dunning
  • Xiaoqing Chen
  • Jun Li
  • Kyriaki Michailidou
  • Yi Lu
  • David N Rider
  • Rachel T Palmieri
  • Michael D Stutz
  • Diether Lambrechts
  • Evelyn Despierre
  • Sandrina Lambrechts
  • Ignace Vergote
  • Jenny Chang-Claude
  • Stefan Nickels
  • Alina Vrieling
  • Dieter Flesch-Janys
  • Shan Wang-Gohrke
  • Ursula Eilber
  • Natalia Bogdanova
  • Natalia Antonenkova
  • Ingo B Runnebaum
  • Thilo Dörk
  • Marc T Goodman
  • Galina Lurie
  • Lynne R Wilkens
  • Rayna K Matsuno
  • Lambertus A Kiemeney
  • Katja K H Aben
  • Tamara Marees
  • Leon F A G Massuger
  • Brooke L Fridley
  • Robert A Vierkant
  • Elisa V Bandera
  • Sara H Olson
  • Irene Orlow
  • Lorna Rodriguez-Rodriguez
  • Linda S Cook
  • Nhu D Le
  • Angela Brooks-Wilson
  • Linda E Kelemen
  • Ian Campbell
  • Simon A Gayther
  • Susan J Ramus
  • Aleksandra Gentry-Maharaj
  • Usha Menon
  • Shahana Ahmed
  • Caroline Baynes
  • Paul D Pharoah
  • kConFab Investigators
  • Australian Ovarian Cancer Study Group
  • ABCTB Investigators
  • Kenneth Muir
  • Artitaya Lophatananon
  • Arkom Chaiwerawattana
  • Surapon Wiangnon
  • Stuart Macgregor
  • Douglas F Easton
  • Roger R Reddel
  • Ellen L Goode
  • Georgia Chenevix-Trench
  • on behalf of the Ovarian Cancer Association Consortium

Abstract

Genetic variation at the TERT-CLPTM1L locus at 5p15.33 is associated with susceptibility to several cancers, including epithelial ovarian cancer (EOC). We have carried out fine-mapping of this region in EOC which implicates an association with a single nucleotide polymorphism (SNP) within the TERT promoter. We demonstrate that the minor alleles at rs2736109, and at an additional TERT promoter SNP, rs2736108, are associated with decreased breast cancer risk, and that the combination of both SNPs substantially reduces TERT promoter activity.

Suggested Citation

  • Jonathan Beesley & Hilda A Pickett & Sharon E Johnatty & Alison M Dunning & Xiaoqing Chen & Jun Li & Kyriaki Michailidou & Yi Lu & David N Rider & Rachel T Palmieri & Michael D Stutz & Diether Lambrec, 2011. "Functional Polymorphisms in the TERT Promoter Are Associated with Risk of Serous Epithelial Ovarian and Breast Cancers," PLOS ONE, Public Library of Science, vol. 6(9), pages 1-6, September.
    • Handle: RePEc:plo:pone00:0024987
    DOI: 10.1371/journal.pone.0024987
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0024987
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0024987&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0024987?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Sharon E Johnatty & Jonathan Beesley & Xiaoqing Chen & Stuart Macgregor & David L Duffy & Amanda B Spurdle & Anna deFazio & Natalie Gava & Penelope M Webb & Australian Ovarian Cancer Study Group & Aus, 2010. "Evaluation of Candidate Stromal Epithelial Cross-Talk Genes Identifies Association between Risk of Serous Ovarian Cancer and TERT, a Cancer Susceptibility “Hot-Spot”," PLOS Genetics, Public Library of Science, vol. 6(7), pages 1-10, July.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.

      More about this item

      Statistics

      Access and download statistics

      Corrections

      All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0024987. See general information about how to correct material in RePEc.

      If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

      If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

      If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

      For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

      Please note that corrections may take a couple of weeks to filter through the various RePEc services.

      IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.