IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0024871.html
   My bibliography  Save this article

Coverage, Adherence and Costs of Intermittent Preventive Treatment of Malaria in Children Employing Different Delivery Strategies in Jasikan, Ghana

Author

Listed:
  • Edith Patouillard
  • Lesong Conteh
  • Jayne Webster
  • Margaret Kweku
  • Daniel Chandramohan
  • Brian Greenwood

Abstract

Background: Intermittent preventive treatment of malaria in children (IPTc) involves the administration of a course of anti-malarial drugs at specified time intervals to children at risk of malaria regardless of whether or not they are known to be infected. IPTc provides a high level of protection against uncomplicated and severe malaria, with monthly sulphadoxine-pyrimethamine plus amodiaquine (SP&AQ) and sulphadoxine-pyrimethamine plus piperaquine being the most efficacious regimens. A key challenge is the identification of a cost-effective delivery strategy. Methods: A community randomized trial was undertaken in Jasikan district, Ghana to assess IPTc effectiveness and costs using SP&AQ delivered in three different ways. Twelve villages were randomly selected to receive IPTc from village health workers (VHWs) or facility-based nurses working at health centres' outpatient departments (OPD) or EPI outreach clinics. Children aged 3 to 59 months-old received one IPT course (three doses) in May, June, September and October. Effectiveness was measured in terms of children covered and adherent to a course and delivery costs were calculated in financial and economic terms using an ingredient approach from the provider perspective. Results: The economic cost per child receiving at least the first dose of all 4 courses was US$4.58 when IPTc was delivered by VHWs, US$4.93 by OPD nurses and US$ 5.65 by EPI nurses. The unit economic cost of receiving all 3 doses of all 4 courses was US$7.56 and US$8.51 when IPTc was delivered by VHWs or facility-based nurses respectively. The main cost driver for the VHW delivery was supervision, reflecting resources used for travelling to more remote communities rather than more intense supervision, and for OPD and EPI delivery, it was the opportunity cost of the time spent by nurses in dispensing IPTc. Conclusions: VHWs achieve higher IPTc coverage and adherence at lower costs than facility-based nurses in Jasikan district, Ghana. Trial Registration: ClinicalTrials.gov NCT00119132.

Suggested Citation

  • Edith Patouillard & Lesong Conteh & Jayne Webster & Margaret Kweku & Daniel Chandramohan & Brian Greenwood, 2011. "Coverage, Adherence and Costs of Intermittent Preventive Treatment of Malaria in Children Employing Different Delivery Strategies in Jasikan, Ghana," PLOS ONE, Public Library of Science, vol. 6(11), pages 1-9, November.
    • Handle: RePEc:plo:pone00:0024871
    DOI: 10.1371/journal.pone.0024871
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0024871
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0024871&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0024871?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Anne L Wilson & on behalf of the IPTc Taskforce, 2011. "A Systematic Review and Meta-Analysis of the Efficacy and Safety of Intermittent Preventive Treatment of Malaria in Children (IPTc)," PLOS ONE, Public Library of Science, vol. 6(2), pages 1-12, February.
    2. Kalifa A Bojang & Francis Akor & Lesong Conteh & Emily Webb & Ousman Bittaye & David J Conway & Momodou Jasseh & Virginia Wiseman & Paul J Milligan & Brian Greenwood, 2011. "Two Strategies for the Delivery of IPTc in an Area of Seasonal Malaria Transmission in The Gambia: A Randomised Controlled Trial," PLOS Medicine, Public Library of Science, vol. 8(2), pages 1-14, February.
    3. Lesong Conteh & Edith Patouillard & Margaret Kweku & Rosa Legood & Brian Greenwood & Daniel Chandramohan, 2010. "Cost Effectiveness of Seasonal Intermittent Preventive Treatment Using Amodiaquine & Artesunate or Sulphadoxine-Pyrimethamine in Ghanaian Children," PLOS ONE, Public Library of Science, vol. 5(8), pages 1-11, August.
    4. McCombie, S. C., 1996. "Treatment seeking for malaria: A review of recent research," Social Science & Medicine, Elsevier, vol. 43(6), pages 933-945, September.
    5. Van Der Geest, Sjaak, 1987. "Self-care and the informal sale of drugs in South Cameroon," Social Science & Medicine, Elsevier, vol. 25(3), pages 293-305, January.
    6. Virginia Wiseman & Michelle Kim & Theonest K Mutabingwa & Christopher J M Whitty, 2006. "Cost-Effectiveness Study of Three Antimalarial Drug Combinations in Tanzania," PLOS Medicine, Public Library of Science, vol. 3(10), pages 1-7, October.
    7. Abdisalan M Noor & Abdinasir A Amin & Willis S Akhwale & Robert W Snow, 2007. "Increasing Coverage and Decreasing Inequity in Insecticide-Treated Bed Net Use among Rural Kenyan Children," PLOS Medicine, Public Library of Science, vol. 4(8), pages 1-8, August.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Halimatou Diawara & Patrick Walker & Matt Cairns & Laura C Steinhardt & Fatou Diawara & Beh Kamate & Laetitia Duval & Elisa Sicuri & Issaka Sagara & Aboubacar Sadou & Jules Mihigo & Erin Eckert & Alas, 2021. "Cost-effectiveness of district-wide seasonal malaria chemoprevention when implemented through routine malaria control programme in Kita, Mali using fixed point distribution," Post-Print hal-03184961, HAL.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Hamma Maiga & Jean Gaudart & Issaka Sagara & Modibo Diarra & Amadou Bamadio & Moussa Djimde & Samba Coumare & Boubou Sangare & Yeyia Dicko & Aly Tembely & Djibril Traore & Alassane Dicko & Estrella La, 2020. "Two-Year Scale-Up of Seasonal Malaria Chemoprevention Reduced Malaria Morbidity among Children in the Health District of Koutiala, Mali," IJERPH, MDPI, vol. 17(18), pages 1-10, September.
    2. Leonard, Lori, 2005. "Where there is no state: household strategies for the management of illness in Chad," Social Science & Medicine, Elsevier, vol. 61(1), pages 229-243, July.
    3. Andrew J. Mirelman & Miqdad Asaria & Bryony Dawkins & Susan Griffin & Richard Cookson & Peter Berman, 2020. "Fairer Decisions, Better Health for All: Health Equity and Cost-Effectiveness Analysis," World Scientific Book Chapters, in: Paul Revill & Marc Suhrcke & Rodrigo Moreno-Serra & Mark Sculpher (ed.), Global Health Economics Shaping Health Policy in Low- and Middle-Income Countries, chapter 4, pages 99-132, World Scientific Publishing Co. Pte. Ltd..
    4. Kempter, Elisabeth & Upadhayay, Neha Bhardwaj, 2022. "Uncovering the role of education in the uptake of preventive measures against Malaria in the African population," University of Tübingen Working Papers in Business and Economics 155, University of Tuebingen, Faculty of Economics and Social Sciences, School of Business and Economics.
    5. Väänänen, Minna Heleena & Lyles, Alan & Airaksinen, Marja, 2009. "The symptom mitigation path of mobile community residents: Community pharmacy's role," Health Policy, Elsevier, vol. 89(1), pages 14-25, January.
    6. Alfredo Paloyo & Arndt Reichert, 2017. "Biting Back at Malaria: Assessing Health-service Providers' Compliance with Treatment Guidelines," Review of Development Economics, Wiley Blackwell, vol. 21(3), pages 591-626, August.
    7. Wiseman, Virginia & Scott, Anthony & Conteh, Lesong & McElroy, Brendan & Stevens, Warren, 2008. "Determinants of provider choice for malaria treatment: Experiences from The Gambia," Social Science & Medicine, Elsevier, vol. 67(4), pages 487-496, August.
    8. Foster, S. D., 1990. "Improving the supply and use of essential drugs in sub-Saharan Africa," Policy Research Working Paper Series 456, The World Bank.
    9. Filmer,Deon P., 2002. "Fever and its treatment among the more and less poor in Sub-Saharan Africa," Policy Research Working Paper Series 2798, The World Bank.
    10. Jayne Webster & Kassoum Kayentao & Samba Diarra & Sory I Diawara & Alhassane Ag Haiballa & Ogobara K Doumbo & Jenny Hill, 2013. "A Qualitative Health Systems Effectiveness Analysis of the Prevention of Malaria in Pregnancy with Intermittent Preventive Treatment and Insecticide Treated Nets in Mali," PLOS ONE, Public Library of Science, vol. 8(7), pages 1-12, July.
    11. Chandler, Clare I.R. & Hall-Clifford, Rachel & Asaph, Turinde & Pascal, Magnussen & Clarke, Siân & Mbonye, Anthony K., 2011. "Introducing malaria rapid diagnostic tests at registered drug shops in Uganda: Limitations of diagnostic testing in the reality of diagnosis," Social Science & Medicine, Elsevier, vol. 72(6), pages 937-944, March.
    12. Amar Hamoudi & Jeffrey D. Sachs, 1999. "The Changing Global Distribution of Malaria: A Review," CID Working Papers 2, Center for International Development at Harvard University.
    13. Gregory Jones & Reidar Hagtvedt, 2008. "Marketing in Heterozygous Advantage," Journal of Business Ethics, Springer, vol. 77(1), pages 85-97, January.
    14. Mbonye, Anthony K. & Bygbjerg, Ib & Magnussen, Pascal, 2007. "Intermittent preventive treatment of malaria in pregnancy: Evaluation of a new delivery approach and the policy implications for malaria control in Uganda," Health Policy, Elsevier, vol. 81(2-3), pages 228-241, May.
    15. Hoffmann, Vivian & Barrett, Christopher B. & Just, David R., 2009. "Do Free Goods Stick to Poor Households? Experimental Evidence on Insecticide Treated Bednets," World Development, Elsevier, vol. 37(3), pages 607-617, March.
    16. Chinwoke Isiguzo & Jennifer Anyanti & Chinazo Ujuju & Ernest Nwokolo & Anna De La Cruz & Eric Schatzkin & Sepideh Modrek & Dominic Montagu & Jenny Liu, 2014. "Presumptive Treatment of Malaria from Formal and Informal Drug Vendors in Nigeria," PLOS ONE, Public Library of Science, vol. 9(10), pages 1-14, October.
    17. Okeke, Theodora A. & Okeibunor, Joseph C., 2010. "Rural-urban differences in health-seeking for the treatment of childhood malaria in south-east Nigeria," Health Policy, Elsevier, vol. 95(1), pages 62-68, April.
    18. Baxerres, Carine & Le Hesran, Jean-Yves, 2011. "Where do pharmaceuticals on the market originate? An analysis of the informal drug supply in Cotonou, Benin," Social Science & Medicine, Elsevier, vol. 73(8), pages 1249-1256.
    19. Irineu de Brito & Silvia Uneddu & Emma Maspero & Paulo Gonçalves, 2020. "Optimizing Long-Lasting Insecticidal Nets Campaign in Ivory Coast," Logistics, MDPI, vol. 4(3), pages 1-21, August.
    20. Eve Worrall, 2009. "The Relationship Between Socio-Economic Status and Malaria: A Review of the Literature," Working Papers id:2021, eSocialSciences.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0024871. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.