IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v17y2020i18p6639-d412341.html
   My bibliography  Save this article

Two-Year Scale-Up of Seasonal Malaria Chemoprevention Reduced Malaria Morbidity among Children in the Health District of Koutiala, Mali

Author

Listed:
  • Hamma Maiga

    (Institut National de Santé Publique, Bamako BP: 1771, Mali
    Malaria Research and Training Center, Department of Epidemiology of Parasitic Diseases, Faculty of Medicine and Dentistry, Faculty of Pharmacy, University of Sciences, Techniques and Technologies of Bamako, Bamako BP: 1805, Mali)

  • Jean Gaudart

    (Aix Marseille Univ, APHM, IRD, INSERM, UMR1252 SESSTIM Sciences Economiques & Sociales de la Santé & Traitement de l’Information Médicale, Hop Timone, BioSTIC, Biostatistic & ICT, 13385 Marseille, France)

  • Issaka Sagara

    (Malaria Research and Training Center, Department of Epidemiology of Parasitic Diseases, Faculty of Medicine and Dentistry, Faculty of Pharmacy, University of Sciences, Techniques and Technologies of Bamako, Bamako BP: 1805, Mali
    Aix Marseille Univ, APHM, IRD, INSERM, UMR1252 SESSTIM Sciences Economiques & Sociales de la Santé & Traitement de l’Information Médicale, Hop Timone, BioSTIC, Biostatistic & ICT, 13385 Marseille, France)

  • Modibo Diarra

    (Malaria Research and Training Center, Department of Epidemiology of Parasitic Diseases, Faculty of Medicine and Dentistry, Faculty of Pharmacy, University of Sciences, Techniques and Technologies of Bamako, Bamako BP: 1805, Mali)

  • Amadou Bamadio

    (Malaria Research and Training Center, Department of Epidemiology of Parasitic Diseases, Faculty of Medicine and Dentistry, Faculty of Pharmacy, University of Sciences, Techniques and Technologies of Bamako, Bamako BP: 1805, Mali)

  • Moussa Djimde

    (Malaria Research and Training Center, Department of Epidemiology of Parasitic Diseases, Faculty of Medicine and Dentistry, Faculty of Pharmacy, University of Sciences, Techniques and Technologies of Bamako, Bamako BP: 1805, Mali)

  • Samba Coumare

    (Malaria Research and Training Center, Department of Epidemiology of Parasitic Diseases, Faculty of Medicine and Dentistry, Faculty of Pharmacy, University of Sciences, Techniques and Technologies of Bamako, Bamako BP: 1805, Mali)

  • Boubou Sangare

    (Malaria Research and Training Center, Department of Epidemiology of Parasitic Diseases, Faculty of Medicine and Dentistry, Faculty of Pharmacy, University of Sciences, Techniques and Technologies of Bamako, Bamako BP: 1805, Mali
    Deceased.)

  • Yeyia Dicko

    (Malaria Research and Training Center, Department of Epidemiology of Parasitic Diseases, Faculty of Medicine and Dentistry, Faculty of Pharmacy, University of Sciences, Techniques and Technologies of Bamako, Bamako BP: 1805, Mali)

  • Aly Tembely

    (Malaria Research and Training Center, Department of Epidemiology of Parasitic Diseases, Faculty of Medicine and Dentistry, Faculty of Pharmacy, University of Sciences, Techniques and Technologies of Bamako, Bamako BP: 1805, Mali)

  • Djibril Traore

    (Malaria Research and Training Center, Department of Epidemiology of Parasitic Diseases, Faculty of Medicine and Dentistry, Faculty of Pharmacy, University of Sciences, Techniques and Technologies of Bamako, Bamako BP: 1805, Mali)

  • Alassane Dicko

    (Malaria Research and Training Center, Department of Epidemiology of Parasitic Diseases, Faculty of Medicine and Dentistry, Faculty of Pharmacy, University of Sciences, Techniques and Technologies of Bamako, Bamako BP: 1805, Mali)

  • Estrella Lasry

    (Médecins Sans Frontières (MSF), New York, NY 10006, USA)

  • Ogobara Doumbo

    (Malaria Research and Training Center, Department of Epidemiology of Parasitic Diseases, Faculty of Medicine and Dentistry, Faculty of Pharmacy, University of Sciences, Techniques and Technologies of Bamako, Bamako BP: 1805, Mali
    Aix Marseille Univ, APHM, IRD, INSERM, UMR1252 SESSTIM Sciences Economiques & Sociales de la Santé & Traitement de l’Information Médicale, Hop Timone, BioSTIC, Biostatistic & ICT, 13385 Marseille, France
    Deceased.)

  • Abdoulaye A. Djimde

    (Malaria Research and Training Center, Department of Epidemiology of Parasitic Diseases, Faculty of Medicine and Dentistry, Faculty of Pharmacy, University of Sciences, Techniques and Technologies of Bamako, Bamako BP: 1805, Mali)

Abstract

Background: Previous controlled studies demonstrated seasonal malaria chemoprevention (SMC) reduces malaria morbidity by >80% in children aged 3–59 months. Here, we assessed malaria morbidity after large-scale SMC implementation during a pilot campaign in the health district of Koutiala, Mali. Methods: Starting in August 2012, children received three rounds of SMC with sulfadoxine-pyrimethamine (SP) and amodiaquine (AQ). From July 2013 onward, children received four rounds of SMC. Prevalence of malaria infection, clinical malaria and anemia were assessed during two cross-sectional surveys conducted in August 2012 and June 2014. Investigations involved 20 randomly selected clusters in 2012 against 10 clusters in 2014. Results: Overall, 662 children were included in 2012, and 670 in 2014. Children in 2014 versus those surveyed in 2012 showed reduced proportions of malaria infection (12.4% in 2014 versus 28.7% in 2012 ( p = 0.001)), clinical malaria (0.3% versus 4.2%, respectively ( p < 0.001)), and anemia (50.1% versus 67.4%, respectively ( p = 0.001)). A propensity score approach that accounts for environmental differences showed that SMC conveyed a significant protective effect against malaria infection (IR = 0.01, 95% CI (0.0001; 0.09), clinical malaria (OR = 0.25, 95% CI (0.06; 0.85)), and hemoglobin concentration (β = 1.3, 95% CI (0.69; 1.96)) in 2012 and 2014, respectively. Conclusion: SMC significantly reduced frequency of malaria infection, clinical malaria and anemia two years after SMC scale-up in Koutiala.

Suggested Citation

  • Hamma Maiga & Jean Gaudart & Issaka Sagara & Modibo Diarra & Amadou Bamadio & Moussa Djimde & Samba Coumare & Boubou Sangare & Yeyia Dicko & Aly Tembely & Djibril Traore & Alassane Dicko & Estrella La, 2020. "Two-Year Scale-Up of Seasonal Malaria Chemoprevention Reduced Malaria Morbidity among Children in the Health District of Koutiala, Mali," IJERPH, MDPI, vol. 17(18), pages 1-10, September.
    • Handle: RePEc:gam:jijerp:v:17:y:2020:i:18:p:6639-:d:412341
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/17/18/6639/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/17/18/6639/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Kalifa A Bojang & Francis Akor & Lesong Conteh & Emily Webb & Ousman Bittaye & David J Conway & Momodou Jasseh & Virginia Wiseman & Paul J Milligan & Brian Greenwood, 2011. "Two Strategies for the Delivery of IPTc in an Area of Seasonal Malaria Transmission in The Gambia: A Randomised Controlled Trial," PLOS Medicine, Public Library of Science, vol. 8(2), pages 1-14, February.
    2. Lesong Conteh & Edith Patouillard & Margaret Kweku & Rosa Legood & Brian Greenwood & Daniel Chandramohan, 2010. "Cost Effectiveness of Seasonal Intermittent Preventive Treatment Using Amodiaquine & Artesunate or Sulphadoxine-Pyrimethamine in Ghanaian Children," PLOS ONE, Public Library of Science, vol. 5(8), pages 1-11, August.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Edith Patouillard & Lesong Conteh & Jayne Webster & Margaret Kweku & Daniel Chandramohan & Brian Greenwood, 2011. "Coverage, Adherence and Costs of Intermittent Preventive Treatment of Malaria in Children Employing Different Delivery Strategies in Jasikan, Ghana," PLOS ONE, Public Library of Science, vol. 6(11), pages 1-9, November.
    2. Amanda Ross & Nicolas Maire & Elisa Sicuri & Thomas Smith & Lesong Conteh, 2011. "Determinants of the Cost-Effectiveness of Intermittent Preventive Treatment for Malaria in Infants and Children," PLOS ONE, Public Library of Science, vol. 6(4), pages 1-12, April.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:17:y:2020:i:18:p:6639-:d:412341. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.