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Human Herpesvirus 8 Seropositivity Among Sexually Active Adults in Uganda

Author

Listed:
  • Fatma M Shebl
  • Sheila C Dollard
  • Ruth M Pfeiffer
  • Benon Biryahwaho
  • Minal M Amin
  • Stella S Munuo
  • Wolfgang Hladik
  • Ruth Parsons
  • Barry I Graubard
  • Sam M Mbulaiteye

Abstract

Introduction: Sexual transmission of human herpesvirus 8 (HHV8) has been implicated among homosexual men, but the evidence for sexual transmission among heterosexual individuals is controversial. We investigated the role of sexual transmission of HHV8 in a nationally representative sample in Uganda, where HHV8 infection is endemic and transmitted mostly during childhood. Materials and Methods: The study population was a subset of participants (n = 2681) from a population-based HIV/AIDS serobehavioral survey of adults aged 15–59 years conducted in 2004/2005. High risk for sexual transmission was assessed by questionnaire and serological testing for HIV and herpes simplex virus 2. Anti-HHV8 antibodies were measured using two enzyme immunoassays targeting synthetic peptides from the K8.1 and orf65 viral genes. The current study was restricted to 2288 sexually active adults. ORs and 95% CIs for HHV8 seropositivity were estimated by fitting logistic regression models with a random intercept using MPLUS and SAS software. Results: The weighted prevalence of HHV8 seropositivity was 56.2%, based on 1302 seropositive individuals, and it increased significantly with age (Ptrend

Suggested Citation

  • Fatma M Shebl & Sheila C Dollard & Ruth M Pfeiffer & Benon Biryahwaho & Minal M Amin & Stella S Munuo & Wolfgang Hladik & Ruth Parsons & Barry I Graubard & Sam M Mbulaiteye, 2011. "Human Herpesvirus 8 Seropositivity Among Sexually Active Adults in Uganda," PLOS ONE, Public Library of Science, vol. 6(6), pages 1-7, June.
    • Handle: RePEc:plo:pone00:0021286
    DOI: 10.1371/journal.pone.0021286
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