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Null Genotypes of GSTM1 and GSTT1 Contribute to Risk of Cervical Neoplasia: An Evidence-Based Meta-Analysis

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Listed:
  • Lin-Bo Gao
  • Xin-Min Pan
  • Li-Juan Li
  • Wei-Bo Liang
  • Peng Bai
  • Li Rao
  • Xiao-Wei Su
  • Tao Wang
  • Bin Zhou
  • Yong-Gang Wei
  • Lin Zhang

Abstract

Background and Objectives: Glutathione S-transferases (GSTs) are multifunctional enzymes that play a key role in the detoxification of varieties of both endogenous products of oxidative stress and exogenous carcinogens. Methods: In this meta-analysis, twenty-five studies were identified by searching PubMed, EMBASE, ISI Web of Science and CBM databases: 23 evaluated GSTM1 and 19 evaluated GSTT1. Crude odds ratios with corresponding 95% confidence intervals were used to estimate the association between GSTM1 and GSTT1 polymorphisms and risk of cervical neoplasia. Subgroup analyses were conducted by pathological history, ethnicity, source of DNA for genotyping, quality score, and matching variable. Results: The null genotypes of GSTM1 and GSTT1 polymorphisms were associated with a significantly increased risk of cervical neoplasia (for GSTM1: OR = 1.40; 95%CI, 1.19–1.65; for GSTT1: OR = 1.30; 95%CI, 1.05–1.62, respectively). Subgroup analyses showed that the null genotype of GSTM1 increased the risk of cervical neoplasia in Asians, studies with DNA isolation from white blood cells and tissue samples, both high and low quality studies, and matched studies. In GSTM1-GSTT1 interaction analysis, individuals with dual null genotype were associated with a significantly increased risk of cervical neoplasia (OR = 1.72; 95%CI, 1.18–2.51). Conclusion: These findings indicate that GSTM1 and GSTT1 polymorphisms, particularly GSTM1-GSTT1 interaction, may play critical roles in the development of cervical neoplasia. A conservative manner should be adopted to interpret these results because of obvious heterogeneity between-study, unadjusted data, and relatively small sample size in this meta-analysis. Well designed studies with larger sample size are of great value to confirm these results.

Suggested Citation

  • Lin-Bo Gao & Xin-Min Pan & Li-Juan Li & Wei-Bo Liang & Peng Bai & Li Rao & Xiao-Wei Su & Tao Wang & Bin Zhou & Yong-Gang Wei & Lin Zhang, 2011. "Null Genotypes of GSTM1 and GSTT1 Contribute to Risk of Cervical Neoplasia: An Evidence-Based Meta-Analysis," PLOS ONE, Public Library of Science, vol. 6(5), pages 1-7, May.
  • Handle: RePEc:plo:pone00:0020157
    DOI: 10.1371/journal.pone.0020157
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    References listed on IDEAS

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    1. Zheng Ye & Honglin Song & Julian P T Higgins & Paul Pharoah & John Danesh, 2006. "Five Glutathione S-Transferase Gene Variants in 23,452 Cases of Lung Cancer and 30,397 Controls: Meta-Analysis of 130 Studies," PLOS Medicine, Public Library of Science, vol. 3(4), pages 1-1, March.
    2. Patrik K. E. Magnusson & Pär Sparén & Ulf B. Gyllensten, 1999. "Genetic link to cervical tumours," Nature, Nature, vol. 400(6739), pages 29-30, July.
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    Cited by:

    1. Qiuqin Tang & Jing Li & Simin Zhang & Beilei Yuan & Hong Sun & Di Wu & Chuncheng Lu & Wei Wu & Yankai Xia & Hongjuan Ding & Lingqing Hu & Daozhen Chen & Jiahao Sha & Xinru Wang, 2013. "GSTM1 and GSTT1 Null Polymorphisms and Childhood Acute Leukemia Risk: Evidence from 26 Case-Control Studies," PLOS ONE, Public Library of Science, vol. 8(10), pages 1-1, October.
    2. Li-Wen He & Rong Shi & Lei Jiang & Ye Zeng & Wen-Li Ma & Jue-Yu Zhou, 2014. "XRCC1 Gene Polymorphisms and Glioma Risk in Chinese Population: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 9(11), pages 1-10, November.
    3. Xingliang Yang & Shuyu Long & Jianping Deng & Tianxing Deng & Zhihua Gong & Ping Hao, 2013. "Glutathione S-Transferase Polymorphisms (GSTM1, GSTT1 and GSTP1) and Their Susceptibility to Renal Cell Carcinoma: An Evidence-Based Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(5), pages 1-12, May.

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