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Genetic link to cervical tumours

Author

Listed:
  • Patrik K. E. Magnusson

    (Section for Medical Genetics
    University of Uppsala)

  • Pär Sparén

    (Karolinska Institute)

  • Ulf B. Gyllensten

    (Section for Medical Genetics
    University of Uppsala)

Abstract

Cervical cancer is strongly associated with infection by oncogenic types of human papilloma virus (HPV). But only a small fraction of those infected develop cancer, indicating that other factors contribute to the progression to cervical cancer. We have compared incidence of the disease in relatives of cases of cervical tumour and controls, and find a significant familial clustering among biological, but not adoptive, relatives. We find no difference in the risk to siblings who have a mother or father in common, so the clustering cannot be explained by vertical transmission of HPV from mother to child. These results provide epidemiological evidence of a genetic predisposition to cervical cancer.

Suggested Citation

  • Patrik K. E. Magnusson & Pär Sparén & Ulf B. Gyllensten, 1999. "Genetic link to cervical tumours," Nature, Nature, vol. 400(6739), pages 29-30, July.
    • Handle: RePEc:nat:nature:v:400:y:1999:i:6739:d:10.1038_21801
    DOI: 10.1038/21801
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    Cited by:

    1. Lin-Bo Gao & Xin-Min Pan & Li-Juan Li & Wei-Bo Liang & Peng Bai & Li Rao & Xiao-Wei Su & Tao Wang & Bin Zhou & Yong-Gang Wei & Lin Zhang, 2011. "Null Genotypes of GSTM1 and GSTT1 Contribute to Risk of Cervical Neoplasia: An Evidence-Based Meta-Analysis," PLOS ONE, Public Library of Science, vol. 6(5), pages 1-7, May.

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