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Tea Consumption Enhances Endothelial-Dependent Vasodilation; a Meta-Analysis

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  • Rouyanne T Ras
  • Peter L Zock
  • Richard Draijer

Abstract

Background: Tea consumption is associated with a lower risk of cardiovascular disease including stroke. Direct effects of tea components on the vasculature, particularly the endothelium, may partly explain this association. Objective: We performed a meta-analysis of controlled human intervention studies on the effect of tea on flow-mediated dilation (FMD) of the brachial artery, a measurement of endothelial function, which is suggested to be associated with cardiovascular risk. Methods: Human intervention studies were identified by systematic search of the databases Medline, Embase, Chemical Abstracts and Biosis through March 2009 and by hand-searching related articles. Studies were selected based on predefined criteria: intervention with tea as the sole experimental variable, placebo-controlled design, and no missing data on FMD outcome or its variability. A random effects model was used to calculate the pooled overall effect on FMD due to the intake of tea. The impact of various subject and treatment characteristics was investigated in the presence of heterogeneity. Results: In total, 9 studies from different research groups were included with 15 relevant study arms. The overall absolute increase in FMD of tea vs. placebo was 2.6% of the arterial diameter (95% CI: 1.8-3.3%; P-value

Suggested Citation

  • Rouyanne T Ras & Peter L Zock & Richard Draijer, 2011. "Tea Consumption Enhances Endothelial-Dependent Vasodilation; a Meta-Analysis," PLOS ONE, Public Library of Science, vol. 6(3), pages 1-9, March.
  • Handle: RePEc:plo:pone00:0016974
    DOI: 10.1371/journal.pone.0016974
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    Cited by:

    1. Hadi Nobari & Saber Saedmocheshi & Linda H. Chung & Katsuhiko Suzuki & Marcos Maynar-Mariño & Jorge Pérez-Gómez, 2021. "An Overview on How Exercise with Green Tea Consumption Can Prevent the Production of Reactive Oxygen Species and Improve Sports Performance," IJERPH, MDPI, vol. 19(1), pages 1-14, December.
    2. Arno Greyling & Rouyanne T Ras & Peter L Zock & Mario Lorenz & Maria T Hopman & Dick H J Thijssen & Richard Draijer, 2014. "The Effect of Black Tea on Blood Pressure: A Systematic Review with Meta-Analysis of Randomized Controlled Trials," PLOS ONE, Public Library of Science, vol. 9(7), pages 1-9, July.

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