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Identifying Consensus Disease Pathways in Parkinson's Disease Using an Integrative Systems Biology Approach

Author

Listed:
  • Yvonne J K Edwards
  • Gary W Beecham
  • William K Scott
  • Sawsan Khuri
  • Guney Bademci
  • Demet Tekin
  • Eden R Martin
  • Zhijie Jiang
  • Deborah C Mash
  • Jarlath ffrench-Mullen
  • Margaret A Pericak-Vance
  • Nicholas Tsinoremas
  • Jeffery M Vance

Abstract

Parkinson's disease (PD) has had six genome-wide association studies (GWAS) conducted as well as several gene expression studies. However, only variants in MAPT and SNCA have been consistently replicated. To improve the utility of these approaches, we applied pathway analyses integrating both GWAS and gene expression. The top 5000 SNPs (p

Suggested Citation

  • Yvonne J K Edwards & Gary W Beecham & William K Scott & Sawsan Khuri & Guney Bademci & Demet Tekin & Eden R Martin & Zhijie Jiang & Deborah C Mash & Jarlath ffrench-Mullen & Margaret A Pericak-Vance &, 2011. "Identifying Consensus Disease Pathways in Parkinson's Disease Using an Integrative Systems Biology Approach," PLOS ONE, Public Library of Science, vol. 6(2), pages 1-11, February.
    • Handle: RePEc:plo:pone00:0016917
    DOI: 10.1371/journal.pone.0016917
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    References listed on IDEAS

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    1. Timothy G Lesnick & Spiridon Papapetropoulos & Deborah C Mash & Jarlath Ffrench-Mullen & Lina Shehadeh & Mariza de Andrade & John R Henley & Walter A Rocca & J Eric Ahlskog & Demetrius M Maraganore, 2007. "A Genomic Pathway Approach to a Complex Disease: Axon Guidance and Parkinson Disease," PLOS Genetics, Public Library of Science, vol. 3(6), pages 1-12, June.
    2. Hariklia Eleftherohorinou & Victoria Wright & Clive Hoggart & Anna-Liisa Hartikainen & Marjo-Riitta Jarvelin & David Balding & Lachlan Coin & Michael Levin, 2009. "Pathway Analysis of GWAS Provides New Insights into Genetic Susceptibility to 3 Inflammatory Diseases," PLOS ONE, Public Library of Science, vol. 4(11), pages 1-11, November.
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    Cited by:

    1. Alexandra Dumitriu & Jeanne C Latourelle & Tiffany C Hadzi & Nathan Pankratz & Dan Garza & John P Miller & Jeffery M Vance & Tatiana Foroud & Thomas G Beach & Richard H Myers, 2012. "Gene Expression Profiles in Parkinson Disease Prefrontal Cortex Implicate FOXO1 and Genes under Its Transcriptional Regulation," PLOS Genetics, Public Library of Science, vol. 8(6), pages 1-11, June.

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