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Optimal Homogenization of Perfusion Flows in Microfluidic Bio-Reactors: A Numerical Study

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  • Fridolin Okkels
  • Martin Dufva
  • Henrik Bruus

Abstract

In recent years, the interest in small-scale bio-reactors has increased dramatically. To ensure homogeneous conditions within the complete area of perfused microfluidic bio-reactors, we develop a general design of a continually feed bio-reactor with uniform perfusion flow. This is achieved by introducing a specific type of perfusion inlet to the reaction area. The geometry of these inlets are found using the methods of topology optimization and shape optimization. The results are compared with two different analytic models, from which a general parametric description of the design is obtained and tested numerically. Such a parametric description will generally be beneficial for the design of a broad range of microfluidic bioreactors used for, e.g., cell culturing and analysis and in feeding bio-arrays.

Suggested Citation

  • Fridolin Okkels & Martin Dufva & Henrik Bruus, 2011. "Optimal Homogenization of Perfusion Flows in Microfluidic Bio-Reactors: A Numerical Study," PLOS ONE, Public Library of Science, vol. 6(1), pages 1-7, January.
    • Handle: RePEc:plo:pone00:0014574
    DOI: 10.1371/journal.pone.0014574
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    1. Jamil El-Ali & Peter K. Sorger & Klavs F. Jensen, 2006. "Cells on chips," Nature, Nature, vol. 442(7101), pages 403-411, July.
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