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Cells on chips

Author

Listed:
  • Jamil El-Ali

    (Center for Cell Decision Processes, Massachusetts Institute of Technology)

  • Peter K. Sorger

    (Center for Cell Decision Processes, Massachusetts Institute of Technology)

  • Klavs F. Jensen

    (Center for Cell Decision Processes, Massachusetts Institute of Technology)

Abstract

Microsystems create new opportunities for the spatial and temporal control of cell growth and stimuli by combining surfaces that mimic complex biochemistries and geometries of the extracellular matrix with microfluidic channels that regulate transport of fluids and soluble factors. Further integration with bioanalytic microsystems results in multifunctional platforms for basic biological insights into cells and tissues, as well as for cell-based sensors with biochemical, biomedical and environmental functions. Highly integrated microdevices show great promise for basic biomedical and pharmaceutical research, and robust and portable point-of-care devices could be used in clinical settings, in both the developed and the developing world.

Suggested Citation

  • Jamil El-Ali & Peter K. Sorger & Klavs F. Jensen, 2006. "Cells on chips," Nature, Nature, vol. 442(7101), pages 403-411, July.
    • Handle: RePEc:nat:nature:v:442:y:2006:i:7101:d:10.1038_nature05063
    DOI: 10.1038/nature05063
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    Cited by:

    1. Fridolin Okkels & Martin Dufva & Henrik Bruus, 2011. "Optimal Homogenization of Perfusion Flows in Microfluidic Bio-Reactors: A Numerical Study," PLOS ONE, Public Library of Science, vol. 6(1), pages 1-7, January.
    2. Sofie Bruun Hartmann & Soumyaranjan Mohanty & Kerstin Skovgaard & Louise Brogaard & Frederikke Bjergvang Flagstad & Jenny Emnéus & Anders Wolff & Artur Summerfield & Gregers Jungersen, 2016. "Investigating the Role of Surface Materials and Three Dimensional Architecture on In Vitro Differentiation of Porcine Monocyte-Derived Dendritic Cells," PLOS ONE, Public Library of Science, vol. 11(6), pages 1-19, June.
    3. Brian S. Flowers & Ryan L. Hartman, 2012. "Particle Handling Techniques in Microchemical Processes," Challenges, MDPI, vol. 3(2), pages 1-18, August.

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