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An Updated Meta-Analysis of Risk of Multiple Sclerosis following Infectious Mononucleosis

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  • Adam E Handel
  • Alexander J Williamson
  • Giulio Disanto
  • Lahiru Handunnetthi
  • Gavin Giovannoni
  • Sreeram V Ramagopalan

Abstract

Background: Multiple sclerosis (MS) appears to develop in genetically susceptible individuals as a result of environmental exposures. Epstein-Barr virus (EBV) infection is an almost universal finding among individuals with MS. Symptomatic EBV infection as manifested by infectious mononucleosis (IM) has been shown in a previous meta-analysis to be associated with the risk of MS, however a number of much larger studies have since been published. Methods/Principal Findings: We performed a Medline search to identify articles published since the original meta-analysis investigating MS risk following IM. A total of 18 articles were included in this study, including 19390 MS patients and 16007 controls. We calculated the relative risk of MS following IM using a generic inverse variance with random effects model. This showed that the risk of MS was strongly associated with IM (relative risk (RR) 2.17; 95% confidence interval 1.97–2.39; p

Suggested Citation

  • Adam E Handel & Alexander J Williamson & Giulio Disanto & Lahiru Handunnetthi & Gavin Giovannoni & Sreeram V Ramagopalan, 2010. "An Updated Meta-Analysis of Risk of Multiple Sclerosis following Infectious Mononucleosis," PLOS ONE, Public Library of Science, vol. 5(9), pages 1-5, September.
    • Handle: RePEc:plo:pone00:0012496
    DOI: 10.1371/journal.pone.0012496
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    1. Vijayendra Dasari & Lisa K. McNeil & Kirrilee Beckett & Matthew Solomon & George Ambalathingal & T. Le Thuy & Archana Panikkar & Caitlyn Smith & Martin P. Steinbuck & Aniela Jakubowski & Lochana M. Se, 2023. "Lymph node targeted multi-epitope subunit vaccine promotes effective immunity to EBV in HLA-expressing mice," Nature Communications, Nature, vol. 14(1), pages 1-17, December.

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