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A Role for S1P and S1P1 in Immature-B Cell Egress from Mouse Bone Marrow

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  • João Pedro Pereira
  • Jason G Cyster
  • Ying Xu

Abstract

B lymphocyte egress from secondary lymphoid organs requires sphingosine-1-phosphate (S1P) and S1P receptor-1 (S1P1). However, whether S1P contributes to immature-B cell egress from the bone marrow (BM) has not been fully assessed. Here we report that in S1P- and S1P1-conditionally deficient mice, the number of immature-B cells in the BM parenchyma increased, while it decreased in the blood. Moreover, a slower rate of bromodeoxyuridine incorporation suggested immature-B cells spent longer in the BM of mice in which S1P1-S1P signaling was genetically or pharmacologically impaired. Transgenic expression of S1P1 in developing B cells was sufficient to mobilize pro- and pre-B cells from the BM. We conclude that the S1P1-S1P pathway contributes to egress of immature-B cells from BM, and that this mechanism is partially redundant with other undefined pathways.

Suggested Citation

  • João Pedro Pereira & Jason G Cyster & Ying Xu, 2010. "A Role for S1P and S1P1 in Immature-B Cell Egress from Mouse Bone Marrow," PLOS ONE, Public Library of Science, vol. 5(2), pages 1-6, February.
    • Handle: RePEc:plo:pone00:0009277
    DOI: 10.1371/journal.pone.0009277
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    References listed on IDEAS

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    1. Mehrdad Matloubian & Charles G. Lo & Guy Cinamon & Matthew J. Lesneski & Ying Xu & Volker Brinkmann & Maria L. Allende & Richard L. Proia & Jason G. Cyster, 2004. "Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1," Nature, Nature, vol. 427(6972), pages 355-360, January.
    2. Masaru Ishii & Jackson G. Egen & Frederick Klauschen & Martin Meier-Schellersheim & Yukihiko Saeki & Jean Vacher & Richard L. Proia & Ronald N. Germain, 2009. "Sphingosine-1-phosphate mobilizes osteoclast precursors and regulates bone homeostasis," Nature, Nature, vol. 458(7237), pages 524-528, March.
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    Cited by:

    1. Kristina Nadrah & Thomas C Beck & João P Pereira, 2015. "Immature B Cell Egress from Bone Marrow Is SOCS3 Independent," PLOS ONE, Public Library of Science, vol. 10(8), pages 1-12, August.

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