IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v458y2009i7237d10.1038_nature07713.html
   My bibliography  Save this article

Sphingosine-1-phosphate mobilizes osteoclast precursors and regulates bone homeostasis

Author

Listed:
  • Masaru Ishii

    (Lymphocyte Biology Section
    Laboratory of Biological Imaging, WPI-Immunology Frontier Research Center, Osaka University
    National Osaka Minami Medical Center)

  • Jackson G. Egen

    (Lymphocyte Biology Section)

  • Frederick Klauschen

    (Program in Systems Immunology and Infectious Disease Modeling, National Institute of Allergy and Infectious Diseases, and,)

  • Martin Meier-Schellersheim

    (Program in Systems Immunology and Infectious Disease Modeling, National Institute of Allergy and Infectious Diseases, and,)

  • Yukihiko Saeki

    (National Osaka Minami Medical Center)

  • Jean Vacher

    (Institut de Recherches Cliniques de Montréal)

  • Richard L. Proia

    (Genetics of Development and Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892-1892, USA)

  • Ronald N. Germain

    (Lymphocyte Biology Section
    Program in Systems Immunology and Infectious Disease Modeling, National Institute of Allergy and Infectious Diseases, and,)

Abstract

Controlling bone resorption Bone is a dynamic tissue, constantly undergoing growth, remodelling and degradation. Central to these processes are the osteoclasts, bone-resorbing multinuclear giant cells that differentiate from mononuclear macrophage/monocyte-lineage haematopoietic precursors. Normally bone resorption is balanced by the activity of bone-forming osteoblasts, but in bone-destructive disorders such as osteoporosis, osteoclast activity outpaces osteoblast activity. Now using a mouse model of hormone-deprivation osteoporosis, the blood-born lipid mediator sphingosine-1-phosphate is identified as a key mediator of bone demineralization. It controls the migratory behaviour of osteoclast precursors, thereby regulating bone homeostasis. As a pivotal control point in osteoclastogenesis, sphingosine-1-phosphate may have potential, as a therapeutic target in bone-resorptive disorders.

Suggested Citation

  • Masaru Ishii & Jackson G. Egen & Frederick Klauschen & Martin Meier-Schellersheim & Yukihiko Saeki & Jean Vacher & Richard L. Proia & Ronald N. Germain, 2009. "Sphingosine-1-phosphate mobilizes osteoclast precursors and regulates bone homeostasis," Nature, Nature, vol. 458(7237), pages 524-528, March.
    • Handle: RePEc:nat:nature:v:458:y:2009:i:7237:d:10.1038_nature07713
    DOI: 10.1038/nature07713
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature07713
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature07713?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Shin Koyama & Eijiro Narita & Naoki Shinohara & Junji Miyakoshi, 2014. "Effect of an Intermediate-Frequency Magnetic Field of 23 kHz at 2 mT on Chemotaxis and Phagocytosis in Neutrophil-Like Differentiated Human HL-60 Cells," IJERPH, MDPI, vol. 11(9), pages 1-11, September.
    2. Maki Uenaka & Erika Yamashita & Junichi Kikuta & Akito Morimoto & Tomoka Ao & Hiroki Mizuno & Masayuki Furuya & Tetsuo Hasegawa & Hiroyuki Tsukazaki & Takao Sudo & Keizo Nishikawa & Daisuke Okuzaki & , 2022. "Osteoblast-derived vesicles induce a switch from bone-formation to bone-resorption in vivo," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    3. João Pedro Pereira & Jason G Cyster & Ying Xu, 2010. "A Role for S1P and S1P1 in Immature-B Cell Egress from Mouse Bone Marrow," PLOS ONE, Public Library of Science, vol. 5(2), pages 1-6, February.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:458:y:2009:i:7237:d:10.1038_nature07713. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.