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Association of Mitochondrial DNA Haplogroups with Exceptional Longevity in a Chinese Population

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Listed:
  • Xiao-yun Cai
  • Xiao-feng Wang
  • Shi-lin Li
  • Ji Qian
  • De-gui Qian
  • Fei Chen
  • Ya-jun Yang
  • Zi-yu Yuan
  • Jun Xu
  • Yidong Bai
  • Shun-zhang Yu
  • Li Jin

Abstract

Background: Longevity is a multifactorial trait with a genetic contribution, and mitochondrial DNA (mtDNA) polymorphisms were found to be involved in the phenomenon of longevity. Methodology/Principal Findings: To explore the effects of mtDNA haplogroups on the prevalence of extreme longevity (EL), a population based case-control study was conducted in Rugao – a prefecture city in Jiangsu, China. Case subjects include 463 individuals aged ≥95 yr (EL group). Control subjects include 926 individuals aged 60–69 years (elderly group) and 463 individuals aged 40–49 years (middle-aged group) randomly recruited from Rugao. We observed significant reduction of M9 haplogroups in longevity subjects (0.2%) when compared with both elderly subjects (2.2%) and middle-aged subjects (1.7%). Linear-by-linear association test revealed a significant decreasing trend of N9 frequency from middle-aged subjects (8.6%), elderly subjects (7.2%) and longevity subjects (4.8%) (p = 0.018). In subsequent analysis stratified by gender, linear-by-linear association test revealed a significant increasing trend of D4 frequency from middle-aged subjects (15.8%), elderly subjects (16.4%) and longevity subjects (21.7%) in females (p = 0.025). Conversely, a significant decreasing trend of B4a frequency was observed from middle-aged subjects (4.2%), elderly subjects (3.8%) and longevity subjects (1.7%) in females (p = 0.045). Conclusions: Our observations support the association of mitochondrial DNA haplogroups with exceptional longevity in a Chinese population.

Suggested Citation

  • Xiao-yun Cai & Xiao-feng Wang & Shi-lin Li & Ji Qian & De-gui Qian & Fei Chen & Ya-jun Yang & Zi-yu Yuan & Jun Xu & Yidong Bai & Shun-zhang Yu & Li Jin, 2009. "Association of Mitochondrial DNA Haplogroups with Exceptional Longevity in a Chinese Population," PLOS ONE, Public Library of Science, vol. 4(7), pages 1-6, July.
    • Handle: RePEc:plo:pone00:0006423
    DOI: 10.1371/journal.pone.0006423
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    1. Bo Wen & Hui Li & Daru Lu & Xiufeng Song & Feng Zhang & Yungang He & Feng Li & Yang Gao & Xianyun Mao & Liang Zhang & Ji Qian & Jingze Tan & Jianzhong Jin & Wei Huang & Ranjan Deka & Bing Su & Ranajit, 2004. "Genetic evidence supports demic diffusion of Han culture," Nature, Nature, vol. 431(7006), pages 302-305, September.
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