IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0006034.html
   My bibliography  Save this article

Targeting 160 Candidate Genes for Blood Pressure Regulation with a Genome-Wide Genotyping Array

Author

Listed:
  • Siim Sõber
  • Elin Org
  • Katrin Kepp
  • Peeter Juhanson
  • Susana Eyheramendy
  • Christian Gieger
  • Peter Lichtner
  • Norman Klopp
  • Gudrun Veldre
  • Margus Viigimaa
  • Angela Döring
  • for the Kooperative Gesundheitsforschung in der Region Augsburg study
  • Margus Putku
  • Piret Kelgo
  • for the HYPertension in ESTonia study
  • Sue Shaw-Hawkins
  • Philip Howard
  • Abiodun Onipinla
  • Richard J Dobson
  • Stephen J Newhouse
  • Morris Brown
  • Anna Dominiczak
  • John Connell
  • Nilesh Samani
  • Martin Farrall
  • for the MRC British Genetics of Hypertension study
  • Mark J Caulfield
  • Patricia B Munroe
  • Thomas Illig
  • H-Erich Wichmann
  • Thomas Meitinger
  • Maris Laan

Abstract

The outcome of Genome-Wide Association Studies (GWAS) has challenged the field of blood pressure (BP) genetics as previous candidate genes have not been among the top loci in these scans. We used Affymetrix 500K genotyping data of KORA S3 cohort (n = 1,644; Southern-Germany) to address (i) SNP coverage in 160 BP candidate genes; (ii) the evidence for associations with BP traits in genome-wide and replication data, and haplotype analysis. In total, 160 gene regions (genic region±10 kb) covered 2,411 SNPs across 11.4 Mb. Marker densities in genes varied from 0 (n = 11) to 0.6 SNPs/kb. On average 52.5% of the HAPMAP SNPs per gene were captured. No evidence for association with BP was obtained for 1,449 tested SNPs. Considerable associations (P 50% of HAPMAP SNPs were tagged. In general, genes with higher marker density (>0.2 SNPs/kb) revealed a better chance to reach close to significance associations. Although, none of the detected P-values remained significant after Bonferroni correction (P

Suggested Citation

  • Siim Sõber & Elin Org & Katrin Kepp & Peeter Juhanson & Susana Eyheramendy & Christian Gieger & Peter Lichtner & Norman Klopp & Gudrun Veldre & Margus Viigimaa & Angela Döring & for the Kooperative Ge, 2009. "Targeting 160 Candidate Genes for Blood Pressure Regulation with a Genome-Wide Genotyping Array," PLOS ONE, Public Library of Science, vol. 4(6), pages 1-13, June.
    • Handle: RePEc:plo:pone00:0006034
    DOI: 10.1371/journal.pone.0006034
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0006034
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0006034&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0006034?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Jeffrey M. Friedman & Jeffrey L. Halaas, 1998. "Leptin and the regulation of body weight in mammals," Nature, Nature, vol. 395(6704), pages 763-770, October.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Qin Zeng & Jianfeng Song & Xiaoxiao Sun & Dandan Wang & Xiyan Liao & Yujin Ding & Wanyu Hu & Yayi Jiao & Wuqian Mai & Wufuer Aini & Fanqi Wang & Hui Zhou & Limin Xie & Ying Mei & Yuan Tang & Zhiguo Xi, 2024. "A negative feedback loop between TET2 and leptin in adipocyte regulates body weight," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    2. Anna Lubkowska & Aleksandra Radecka & Iwona Bryczkowska & Iwona Rotter & Maria Laszczyńska & Wioleta Dudzińska, 2015. "Serum Adiponectin and Leptin Concentrations in Relation to Body Fat Distribution, Hematological Indices and Lipid Profile in Humans," IJERPH, MDPI, vol. 12(9), pages 1-21, September.
    3. Smith, Trenton G, 2002. "Obesity and Nature's Thumbprint: How Modern Waistlines Can Inform Economic Theory," University of California at Santa Barbara, Economics Working Paper Series qt31g1m028, Department of Economics, UC Santa Barbara.
    4. Omori, Koji & Sogabe, Atsushi & Hamaoka, Hideki & Ohnishi, Hidejiro, 2009. "Storage and the regulation of body mass in animals: A general growth equation based on an energy balance model," Ecological Modelling, Elsevier, vol. 220(20), pages 2618-2623.
    5. Huszebucza GY & M. Kulcszr & P. Rudas, 2002. "Clinical endocrinology of thyroid gland function in ruminants," Veterinární medicína, Czech Academy of Agricultural Sciences, vol. 47(7), pages 199-210.
    6. Jihoon Shin & Shinichiro Toyoda & Yosuke Okuno & Reiko Hayashi & Shigeki Nishitani & Toshiharu Onodera & Haruyo Sakamoto & Shinya Ito & Sachiko Kobayashi & Hirofumi Nagao & Shunbun Kita & Michio Otsuk, 2023. "HSP47 levels determine the degree of body adiposity," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    7. Jing He & Bo Xi & Rikje Ruiter & Ting-Yan Shi & Mei-Ling Zhu & Meng-Yun Wang & Qiao-Xin Li & Xiao-Yan Zhou & Li-Xin Qiu & Qing-Yi Wei, 2013. "Association of LEP G2548A and LEPR Q223R Polymorphisms with Cancer Susceptibility: Evidence from a Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(10), pages 1-1, October.
    8. Mengling Zhang & Xiangrong Sun & Feifei Guo & Shengli Gao & Yanling Gong & Luo Xu, 2016. "Effect of Orexin-A on Glucose Sensitive Neurons in the Hypothalamus of Rats," International Journal of Sciences, Office ijSciences, vol. 5(07), pages 45-49, July.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0006034. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.