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Leptin and the regulation of body weight in mammals

Author

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  • Jeffrey M. Friedman

    (Laboratory of Molecular Genetics and Howard Hughes Medical Institute
    Laboratory of Molecular Genetics, The Rockefeller University)

  • Jeffrey L. Halaas

    (Laboratory of Molecular Genetics and Howard Hughes Medical Institute
    Laboratory of Molecular Genetics, The Rockefeller University)

Abstract

The assimilation, storage and use of energy from nutrients constitute a homeostatic system that is essential for life. In vertebrates, the ability to store sufficient quantities of energy-dense triglyceride in adipose tissue allows survival during the frequent periods of food deprivation encountered during evolution. However, the presence of excess adipose tissue can be maladaptive. A complex physiological system has evolved to regulate fuel stores and energy balance at an optimum level. Leptin, a hormone secreted by adipose tissue, and its receptor are integral components of this system. Leptin also signals nutritional status to several other physiological systems and modulates their function. Here we review the role of leptin in the control of body weight and its relevance to the pathogenesis of obesity.

Suggested Citation

  • Jeffrey M. Friedman & Jeffrey L. Halaas, 1998. "Leptin and the regulation of body weight in mammals," Nature, Nature, vol. 395(6704), pages 763-770, October.
    • Handle: RePEc:nat:nature:v:395:y:1998:i:6704:d:10.1038_27376
    DOI: 10.1038/27376
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    Cited by:

    1. Jing He & Bo Xi & Rikje Ruiter & Ting-Yan Shi & Mei-Ling Zhu & Meng-Yun Wang & Qiao-Xin Li & Xiao-Yan Zhou & Li-Xin Qiu & Qing-Yi Wei, 2013. "Association of LEP G2548A and LEPR Q223R Polymorphisms with Cancer Susceptibility: Evidence from a Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(10), pages 1-1, October.
    2. Smith, Trenton G, 2002. "Obesity and Nature's Thumbprint: How Modern Waistlines Can Inform Economic Theory," University of California at Santa Barbara, Economics Working Paper Series qt31g1m028, Department of Economics, UC Santa Barbara.
    3. Anna Lubkowska & Aleksandra Radecka & Iwona Bryczkowska & Iwona Rotter & Maria Laszczyńska & Wioleta Dudzińska, 2015. "Serum Adiponectin and Leptin Concentrations in Relation to Body Fat Distribution, Hematological Indices and Lipid Profile in Humans," IJERPH, MDPI, vol. 12(9), pages 1-21, September.
    4. Mengling Zhang & Xiangrong Sun & Feifei Guo & Shengli Gao & Yanling Gong & Luo Xu, 2016. "Effect of Orexin-A on Glucose Sensitive Neurons in the Hypothalamus of Rats," International Journal of Sciences, Office ijSciences, vol. 5(07), pages 45-49, July.
    5. Qin Zeng & Jianfeng Song & Xiaoxiao Sun & Dandan Wang & Xiyan Liao & Yujin Ding & Wanyu Hu & Yayi Jiao & Wuqian Mai & Wufuer Aini & Fanqi Wang & Hui Zhou & Limin Xie & Ying Mei & Yuan Tang & Zhiguo Xi, 2024. "A negative feedback loop between TET2 and leptin in adipocyte regulates body weight," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    6. Huszebucza GY & M. Kulcszr & P. Rudas, 2002. "Clinical endocrinology of thyroid gland function in ruminants," Veterinární medicína, Czech Academy of Agricultural Sciences, vol. 47(7), pages 199-210.
    7. Omori, Koji & Sogabe, Atsushi & Hamaoka, Hideki & Ohnishi, Hidejiro, 2009. "Storage and the regulation of body mass in animals: A general growth equation based on an energy balance model," Ecological Modelling, Elsevier, vol. 220(20), pages 2618-2623.
    8. Jihoon Shin & Shinichiro Toyoda & Yosuke Okuno & Reiko Hayashi & Shigeki Nishitani & Toshiharu Onodera & Haruyo Sakamoto & Shinya Ito & Sachiko Kobayashi & Hirofumi Nagao & Shunbun Kita & Michio Otsuk, 2023. "HSP47 levels determine the degree of body adiposity," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    9. Siim Sõber & Elin Org & Katrin Kepp & Peeter Juhanson & Susana Eyheramendy & Christian Gieger & Peter Lichtner & Norman Klopp & Gudrun Veldre & Margus Viigimaa & Angela Döring & for the Kooperative Ge, 2009. "Targeting 160 Candidate Genes for Blood Pressure Regulation with a Genome-Wide Genotyping Array," PLOS ONE, Public Library of Science, vol. 4(6), pages 1-13, June.

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