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A New Computational Tool for the Phenomenological Analysis of Multipassage Tumor Growth Curves

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  • Antonio S Gliozzi
  • Caterina Guiot
  • Pier Paolo Delsanto

Abstract

Multipassage experiments are performed by subcutaneous implantation in lab animals (usually mice) of a small number of cells from selected human lines. Tumor cells are then passaged from one mouse to another by harvesting them from a growing tumor and implanting them into other healthy animals. This procedure may be extremely useful to investigate the various mechanisms involved in the long term evolution of tumoral growth. It has been observed by several researchers that, contrary to what happens in in vitro experiments, there is a significant growth acceleration at each new passage. This result is explained by a new method of analysis, based on the Phenomenological Universalities approach. It is found that, by means of a simple rescaling of time, it is possible to collapse all the growth curves, corresponding to the successive passages, into a single curve, belonging to the Universality Class U2. Possible applications are proposed and the need of further experimental evidence is discussed.

Suggested Citation

  • Antonio S Gliozzi & Caterina Guiot & Pier Paolo Delsanto, 2009. "A New Computational Tool for the Phenomenological Analysis of Multipassage Tumor Growth Curves," PLOS ONE, Public Library of Science, vol. 4(4), pages 1-7, April.
    • Handle: RePEc:plo:pone00:0005358
    DOI: 10.1371/journal.pone.0005358
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    References listed on IDEAS

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    1. Ben D. MacArthur & Richard O. C. Oreffo, 2005. "Bridging the gap," Nature, Nature, vol. 433(7021), pages 19-19, January.
    2. Geoffrey B. West & James H. Brown & Brian J. Enquist, 2001. "A general model for ontogenetic growth," Nature, Nature, vol. 413(6856), pages 628-631, October.
    3. Geoffrey B. West & James H. Brown & Brian J. Enquist, 1999. "The Fourth Dimension of Life: Fractal Geometry and Allometric Scaling of Organisms," Working Papers 99-07-047, Santa Fe Institute.
    4. James. F. Gillooly & Eric L. Charnov & Geoffrey B. West & Van M. Savage & James H. Brown, 2002. "Effects of size and temperature on developmental time," Nature, Nature, vol. 417(6884), pages 70-73, May.
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    Cited by:

    1. Barberis, L. & Condat, C.A., 2012. "Describing interactive growth using vector universalities," Ecological Modelling, Elsevier, vol. 227(C), pages 56-63.
    2. Barberis, L. & Condat, C.A. & Román, P., 2011. "Vector growth universalities," Chaos, Solitons & Fractals, Elsevier, vol. 44(12), pages 1100-1105.

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