IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0005358.html
   My bibliography  Save this article

A New Computational Tool for the Phenomenological Analysis of Multipassage Tumor Growth Curves

Author

Listed:
  • Antonio S Gliozzi
  • Caterina Guiot
  • Pier Paolo Delsanto

Abstract

Multipassage experiments are performed by subcutaneous implantation in lab animals (usually mice) of a small number of cells from selected human lines. Tumor cells are then passaged from one mouse to another by harvesting them from a growing tumor and implanting them into other healthy animals. This procedure may be extremely useful to investigate the various mechanisms involved in the long term evolution of tumoral growth. It has been observed by several researchers that, contrary to what happens in in vitro experiments, there is a significant growth acceleration at each new passage. This result is explained by a new method of analysis, based on the Phenomenological Universalities approach. It is found that, by means of a simple rescaling of time, it is possible to collapse all the growth curves, corresponding to the successive passages, into a single curve, belonging to the Universality Class U2. Possible applications are proposed and the need of further experimental evidence is discussed.

Suggested Citation

  • Antonio S Gliozzi & Caterina Guiot & Pier Paolo Delsanto, 2009. "A New Computational Tool for the Phenomenological Analysis of Multipassage Tumor Growth Curves," PLOS ONE, Public Library of Science, vol. 4(4), pages 1-7, April.
  • Handle: RePEc:plo:pone00:0005358
    DOI: 10.1371/journal.pone.0005358
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0005358
    Download Restriction: no

    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0005358&type=printable
    Download Restriction: no

    File URL: https://libkey.io/10.1371/journal.pone.0005358?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Ben D. MacArthur & Richard O. C. Oreffo, 2005. "Bridging the gap," Nature, Nature, vol. 433(7021), pages 19-19, January.
    2. Geoffrey B. West & James H. Brown & Brian J. Enquist, 2001. "A general model for ontogenetic growth," Nature, Nature, vol. 413(6856), pages 628-631, October.
    3. Geoffrey B. West & James H. Brown & Brian J. Enquist, 1999. "The Fourth Dimension of Life: Fractal Geometry and Allometric Scaling of Organisms," Working Papers 99-07-047, Santa Fe Institute.
    4. James. F. Gillooly & Eric L. Charnov & Geoffrey B. West & Van M. Savage & James H. Brown, 2002. "Effects of size and temperature on developmental time," Nature, Nature, vol. 417(6884), pages 70-73, May.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Barberis, L. & Condat, C.A., 2012. "Describing interactive growth using vector universalities," Ecological Modelling, Elsevier, vol. 227(C), pages 56-63.
    2. Barberis, L. & Condat, C.A. & Román, P., 2011. "Vector growth universalities," Chaos, Solitons & Fractals, Elsevier, vol. 44(12), pages 1100-1105.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Tao, Yong & Lin, Li & Wang, Hanjie & Hou, Chen, 2023. "Superlinear growth and the fossil fuel energy sustainability dilemma: Evidence from six continents," Structural Change and Economic Dynamics, Elsevier, vol. 66(C), pages 39-51.
    2. Lang, Wei & Long, Ying & Chen, Tingting & Li, Xun, 2019. "Reinvestigating China’s urbanization through the lens of allometric scaling," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 525(C), pages 1429-1439.
    3. Hendriks, A. Jan, 2007. "The power of size: A meta-analysis reveals consistency of allometric regressions," Ecological Modelling, Elsevier, vol. 205(1), pages 196-208.
    4. Francisco Martínez, 2016. "Cities’ power laws: the stochastic scaling factor," Environment and Planning B, , vol. 43(2), pages 257-275, March.
    5. Witting, Lars, 2017. "The natural selection of metabolism and mass selects allometric transitions from prokaryotes to mammals," Theoretical Population Biology, Elsevier, vol. 117(C), pages 23-42.
    6. Dalgaard, Carl-Johan & Strulik, Holger, 2008. "Energy Distribution, Power Laws, and Economic Growth," Hannover Economic Papers (HEP) dp-385, Leibniz Universität Hannover, Wirtschaftswissenschaftliche Fakultät.
    7. Vanessa Taylor & Sarah Ashelford & Patricia Fell & Penelope J Goacher, 2015. "Biosciences in nurse education: is the curriculum fit for practice? Lecturers' views and recommendations from across the UK," Journal of Clinical Nursing, John Wiley & Sons, vol. 24(19-20), pages 2797-2806, October.
    8. Booth, Heather, 2006. "Demographic forecasting: 1980 to 2005 in review," International Journal of Forecasting, Elsevier, vol. 22(3), pages 547-581.
    9. Ercan Tomakin, 2014. "Teaching English Tenses (grammar) in the Turkish Texts; A Case of Simple Present Tense: Is?l Maketi Iter," International Journal of Learning and Development, Macrothink Institute, vol. 4(1), pages 115-131, March.
    10. Elliott, Robert J.R. & Sun, Puyang & Xu, Qiqin, 2015. "Energy distribution and economic growth: An empirical test for China," Energy Economics, Elsevier, vol. 48(C), pages 24-31.
    11. Peter Viggo Jakobsen, 2009. "Small States, Big Influence: The Overlooked Nordic Influence on the Civilian ESDP," Journal of Common Market Studies, Wiley Blackwell, vol. 47(1), pages 81-102, January.
    12. Radha Jagannathan & Michael J. Camasso & Bagavan Das & Jale Tosun & Sadagopan Iyengar, 2017. "Family, society and the individual: determinants of entrepreneurial attitudes among youth in Chennai, South India," Journal of Global Entrepreneurship Research, Springer;UNESCO Chair in Entrepreneurship, vol. 7(1), pages 1-22, December.
    13. Chen, Yanguang, 2014. "An allometric scaling relation based on logistic growth of cities," Chaos, Solitons & Fractals, Elsevier, vol. 65(C), pages 65-77.
    14. Tautenhahn, Susanne & Heilmeier, Hermann & Jung, Martin & Kahl, Anja & Kattge, Jens & Moffat, Antje & Wirth, Christian, 2012. "Beyond distance-invariant survival in inverse recruitment modeling: A case study in Siberian Pinus sylvestris forests," Ecological Modelling, Elsevier, vol. 233(C), pages 90-103.
    15. Vincenzo Galasso, 2020. "Market Reactions to Quest for Decentralization and Independence: Evidence from Catalonia," CESifo Working Paper Series 8254, CESifo.
    16. Thijs Fassaert & Matty A.S. De Wit & Wilco C. Tuinebreijer & Jeroen W. Knipscheer & Arnoud P. Verhoeff & Aartjan T.F. Beekman & Jack Dekker, 2011. "Acculturation and Psychological Distress Among Non-Western Muslim Migrants - a Population-Based Survey," International Journal of Social Psychiatry, , vol. 57(2), pages 132-143, March.
    17. Jakub Bijak & Jason D. Hilton & Eric Silverman & Viet Dung Cao, 2013. "Reforging the Wedding Ring," Demographic Research, Max Planck Institute for Demographic Research, Rostock, Germany, vol. 29(27), pages 729-766.
    18. Philippe De Donder & Michel Le Breton & Eugenio Peluso, 2012. "Majority Voting in Multidimensional Policy Spaces: Kramer–Shepsle versus Stackelberg," Journal of Public Economic Theory, Association for Public Economic Theory, vol. 14(6), pages 879-909, December.
    19. Johnson, Scott N. & Zhang, Xiaoxian & Crawford, John W. & Gregory, Peter J. & Young, Iain M., 2007. "Egg hatching and survival time of soil-dwelling insect larvae: A partial differential equation model and experimental validation," Ecological Modelling, Elsevier, vol. 202(3), pages 493-502.
    20. Grace Kite, 2014. "Linked in? Software and Information Technology Services in India’s Economic Development," Journal of South Asian Development, , vol. 9(2), pages 99-119, August.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0005358. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.