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Efficacy and safety of single-dose 40 mg/kg oral praziquantel in the treatment of schistosomiasis in preschool-age versus school-age children: An individual participant data meta-analysis

Author

Listed:
  • Piero L Olliaro
  • Jean T Coulibaly
  • Amadou Garba
  • Christine Halleux
  • Jennifer Keiser
  • Charles H King
  • Francisca Mutapi
  • Eliézer K N’Goran
  • Giovanna Raso
  • Alexandra U Scherrer
  • José Carlos Sousa-Figueiredo
  • Katarina Stete
  • Jürg Utzinger
  • Michel T Vaillant

Abstract

Background: Better knowledge of the efficacy and safety of single-dose 40 mg/kg oral praziquantel in preschool-age children is required, should preventive chemotherapy programs for schistosomiasis be expanded to include this age group. Methodology: We analyzed individual participant-level data from 16 studies (13 single-arm or cohort studies and three randomized trials), amounting to 683 preschool-age children (aged

Suggested Citation

  • Piero L Olliaro & Jean T Coulibaly & Amadou Garba & Christine Halleux & Jennifer Keiser & Charles H King & Francisca Mutapi & Eliézer K N’Goran & Giovanna Raso & Alexandra U Scherrer & José Carlos Sou, 2020. "Efficacy and safety of single-dose 40 mg/kg oral praziquantel in the treatment of schistosomiasis in preschool-age versus school-age children: An individual participant data meta-analysis," PLOS Neglected Tropical Diseases, Public Library of Science, vol. 14(6), pages 1-23, June.
    • Handle: RePEc:plo:pntd00:0008277
    DOI: 10.1371/journal.pntd.0008277
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    References listed on IDEAS

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    1. Julien Zwang & Piero L Olliaro, 2014. "Clinical Efficacy and Tolerability of Praziquantel for Intestinal and Urinary Schistosomiasis—A Meta-analysis of Comparative and Non-comparative Clinical Trials," PLOS Neglected Tropical Diseases, Public Library of Science, vol. 8(11), pages 1-15, November.
    2. Amélie M Julé & Michel Vaillant & Trudie A Lang & Philippe J Guérin & Piero L Olliaro, 2016. "The Schistosomiasis Clinical Trials Landscape: A Systematic Review of Antischistosomal Treatment Efficacy Studies and a Case for Sharing Individual Participant-Level Data (IPD)," PLOS Neglected Tropical Diseases, Public Library of Science, vol. 10(6), pages 1-17, June.
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