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Uncovering the Pathogenic Landscape of Helminth (Opisthorchis viverrini) Infections: A Cross-Sectional Study on Contributions of Physical and Social Environment and Healthcare Interventions

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  • Xueyuan Ong
  • Yi-Chen Wang
  • Paiboon Sithithaworn
  • Jutamas Namsanor
  • David Taylor
  • Luxana Laithavewat

Abstract

Background: Helminth infections have proven recalcitrant to control by chemotherapy in many parts of Southeast Asia and indeed farther afield. This study isolates and examines the influence of different aspects of the physical and social environment, and uneven intervention effort contributing to the pathogenic landscape of human Opisthorchis viverrini infections. Methodology: A cross-sectional survey, involving 632 participants, was conducted in four villages in northeast Thailand to examine the impact on prevalence and parasite burden of the reservoir dam environment, socio-economic, demographic, and behavioral factors, and health center intervention efforts. Formalin-ether concentration technique was used for diagnoses, and multivariate models were used for analyses. Principal Findings: The importance attributed to O. viverrini infections varied among health centers in the four study villages. Villages where O. viverrini infections were not prioritized by the health centers as the healthcare focus were at a higher risk of infection (prevalence) with odds ratio (risk factor) of 5.73 (3.32–10.27) and p-value

Suggested Citation

  • Xueyuan Ong & Yi-Chen Wang & Paiboon Sithithaworn & Jutamas Namsanor & David Taylor & Luxana Laithavewat, 2016. "Uncovering the Pathogenic Landscape of Helminth (Opisthorchis viverrini) Infections: A Cross-Sectional Study on Contributions of Physical and Social Environment and Healthcare Interventions," PLOS Neglected Tropical Diseases, Public Library of Science, vol. 10(12), pages 1-21, December.
    • Handle: RePEc:plo:pntd00:0005175
    DOI: 10.1371/journal.pntd.0005175
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    References listed on IDEAS

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    2. Xueyuan Ong & Yi-Chen Wang & Paiboon Sithithaworn & Carl Grundy-Warr & Opal Pitaksakulrat, 2016. "Dam Influences on Liver Fluke Transmission: Fish Infection and Human Fish Consumption Behavior," Annals of the American Association of Geographers, Taylor & Francis Journals, vol. 106(4), pages 755-772, July.
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