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Novel Three-Day, Community-Based, Nonpharmacological Group Intervention for Chronic Musculoskeletal Pain (COPERS): A Randomised Clinical Trial

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  • Stephanie J C Taylor
  • Dawn Carnes
  • Kate Homer
  • Brennan C Kahan
  • Natalia Hounsome
  • Sandra Eldridge
  • Anne Spencer
  • Tamar Pincus
  • Anisur Rahman
  • Martin Underwood

Abstract

Background: Chronic musculoskeletal pain is the leading cause of disability worldwide. The effectiveness of pharmacological treatments for chronic pain is often limited, and there is growing concern about the adverse effects of these treatments, including opioid dependence. Nonpharmacological approaches to chronic pain may be an attractive alternative or adjunctive treatment. We describe the effectiveness of a novel, theoretically based group pain management support intervention for chronic musculoskeletal pain. Methods and Findings: We conducted a multi-centre, pragmatic, randomised, controlled effectiveness and cost-effectiveness (cost–utility) trial across 27 general practices and community musculoskeletal services in the UK. We recruited 703 adults with musculoskeletal pain of at least 3 mo duration between August 1, 2011, and July 31, 2012, and randomised participants 1.33:1 to intervention (403) or control (300). Intervention participants were offered a participative group intervention (COPERS) delivered over three alternate days with a follow-up session at 2 wk. The intervention introduced cognitive behavioural approaches and was designed to promote self-efficacy to manage chronic pain. Controls received usual care and a relaxation CD. The primary outcome was pain-related disability at 12 mo (Chronic Pain Grade [CPG] disability subscale); secondary outcomes included the CPG disability subscale at 6 mo and the following measured at 6 and 12 mo: anxiety and depression (Hospital Anxiety and Depression Scale [HADS]), pain acceptance (Chronic Pain Acceptance Questionnaire), social integration (Health Education Impact Questionnaire social integration and support subscale), pain-related self-efficacy (Pain Self-Efficacy Questionnaire), pain intensity (CPG pain intensity subscale), the census global health question (2011 census for England and Wales), health utility (EQ-5D-3L), and health care resource use. Analyses followed the intention-to-treat principle, accounted for clustering by course in the intervention arm, and used multiple imputation for missing or incomplete primary outcome data. Conclusions: While the COPERS intervention was brief, safe, and inexpensive, with a low attrition rate, it was not effective for reducing pain-related disability over 12 mo (primary outcome). For secondary outcomes, we found sustained benefits on depression and social integration at 6 and 12 mo, but there was no effect on anxiety, pain-related self-efficacy, pain acceptance, pain intensity, or the census global health question at 12 mo. There was some evidence that the intervention may be cost-effective based on a modest difference in QALYs between groups. Trial registration: ISRCTN Registry 24426731 In a randomized controlled trial, Stephanie Taylor and colleagues investigate the effectiveness of a group intervention for chronic musculoskeletal pain.Why Was This Study Done?: What Did the Researchers Do and Find?: What Do These Findings Mean?:

Suggested Citation

  • Stephanie J C Taylor & Dawn Carnes & Kate Homer & Brennan C Kahan & Natalia Hounsome & Sandra Eldridge & Anne Spencer & Tamar Pincus & Anisur Rahman & Martin Underwood, 2016. "Novel Three-Day, Community-Based, Nonpharmacological Group Intervention for Chronic Musculoskeletal Pain (COPERS): A Randomised Clinical Trial," PLOS Medicine, Public Library of Science, vol. 13(6), pages 1-18, June.
  • Handle: RePEc:plo:pmed00:1002040
    DOI: 10.1371/journal.pmed.1002040
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    1. Jürgen Barth & Thomas Munder & Heike Gerger & Eveline Nüesch & Sven Trelle & Hansjörg Znoj & Peter Jüni & Pim Cuijpers, 2013. "Comparative Efficacy of Seven Psychotherapeutic Interventions for Patients with Depression: A Network Meta-Analysis," PLOS Medicine, Public Library of Science, vol. 10(5), pages 1-17, May.
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