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A Genome-Wide Scan of Ashkenazi Jewish Crohn's Disease Suggests Novel Susceptibility Loci

Author

Listed:
  • Eimear E Kenny
  • Itsik Pe'er
  • Amir Karban
  • Laurie Ozelius
  • Adele A Mitchell
  • Sok Meng Ng
  • Monica Erazo
  • Harry Ostrer
  • Clara Abraham
  • Maria T Abreu
  • Gil Atzmon
  • Nir Barzilai
  • Steven R Brant
  • Susan Bressman
  • Edward R Burns
  • Yehuda Chowers
  • Lorraine N Clark
  • Ariel Darvasi
  • Dana Doheny
  • Richard H Duerr
  • Rami Eliakim
  • Nir Giladi
  • Peter K Gregersen
  • Hakon Hakonarson
  • Michelle R Jones
  • Karen Marder
  • Dermot P B McGovern
  • Jennifer Mulle
  • Avi Orr-Urtreger
  • Deborah D Proctor
  • Ann Pulver
  • Jerome I Rotter
  • Mark S Silverberg
  • Thomas Ullman
  • Stephen T Warren
  • Matti Waterman
  • Wei Zhang
  • Aviv Bergman
  • Lloyd Mayer
  • Seymour Katz
  • Robert J Desnick
  • Judy H Cho
  • Inga Peter

Abstract

Crohn's disease (CD) is a complex disorder resulting from the interaction of intestinal microbiota with the host immune system in genetically susceptible individuals. The largest meta-analysis of genome-wide association to date identified 71 CD–susceptibility loci in individuals of European ancestry. An important epidemiological feature of CD is that it is 2–4 times more prevalent among individuals of Ashkenazi Jewish (AJ) descent compared to non-Jewish Europeans (NJ). To explore genetic variation associated with CD in AJs, we conducted a genome-wide association study (GWAS) by combining raw genotype data across 10 AJ cohorts consisting of 907 cases and 2,345 controls in the discovery stage, followed up by a replication study in 971 cases and 2,124 controls. We confirmed genome-wide significant associations of 9 known CD loci in AJs and replicated 3 additional loci with strong signal (p

Suggested Citation

  • Eimear E Kenny & Itsik Pe'er & Amir Karban & Laurie Ozelius & Adele A Mitchell & Sok Meng Ng & Monica Erazo & Harry Ostrer & Clara Abraham & Maria T Abreu & Gil Atzmon & Nir Barzilai & Steven R Brant , 2012. "A Genome-Wide Scan of Ashkenazi Jewish Crohn's Disease Suggests Novel Susceptibility Loci," PLOS Genetics, Public Library of Science, vol. 8(3), pages 1-10, March.
    • Handle: RePEc:plo:pgen00:1002559
    DOI: 10.1371/journal.pgen.1002559
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    1. Doron M. Behar & Bayazit Yunusbayev & Mait Metspalu & Ene Metspalu & Saharon Rosset & Jüri Parik & Siiri Rootsi & Gyaneshwer Chaubey & Ildus Kutuev & Guennady Yudkovsky & Elza K. Khusnutdinova & Oleg , 2010. "The genome-wide structure of the Jewish people," Nature, Nature, vol. 466(7303), pages 238-242, July.
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