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Genome-Wide Association Studies of the PR Interval in African Americans

Author

Listed:
  • J Gustav Smith
  • Jared W Magnani
  • Cameron Palmer
  • Yan A Meng
  • Elsayed Z Soliman
  • Solomon K Musani
  • Kathleen F Kerr
  • Renate B Schnabel
  • Steven A Lubitz
  • Nona Sotoodehnia
  • Susan Redline
  • Arne Pfeufer
  • Martina Müller
  • Daniel S Evans
  • Michael A Nalls
  • Yongmei Liu
  • Anne B Newman
  • Alan B Zonderman
  • Michele K Evans
  • Rajat Deo
  • Patrick T Ellinor
  • Dina N Paltoo
  • Christopher Newton-Cheh
  • Emelia J Benjamin
  • Reena Mehra
  • Alvaro Alonso
  • Susan R Heckbert
  • Ervin R Fox
  • Candidate-gene Association Resource (CARe) Consortium

Abstract

The PR interval on the electrocardiogram reflects atrial and atrioventricular nodal conduction time. The PR interval is heritable, provides important information about arrhythmia risk, and has been suggested to differ among human races. Genome-wide association (GWA) studies have identified common genetic determinants of the PR interval in individuals of European and Asian ancestry, but there is a general paucity of GWA studies in individuals of African ancestry. We performed GWA studies in African American individuals from four cohorts (n = 6,247) to identify genetic variants associated with PR interval duration. Genotyping was performed using the Affymetrix 6.0 microarray. Imputation was performed for 2.8 million single nucleotide polymorphisms (SNPs) using combined YRI and CEU HapMap phase II panels. We observed a strong signal (rs3922844) within the gene encoding the cardiac sodium channel (SCN5A) with genome-wide significant association (p

Suggested Citation

  • J Gustav Smith & Jared W Magnani & Cameron Palmer & Yan A Meng & Elsayed Z Soliman & Solomon K Musani & Kathleen F Kerr & Renate B Schnabel & Steven A Lubitz & Nona Sotoodehnia & Susan Redline & Arne , 2011. "Genome-Wide Association Studies of the PR Interval in African Americans," PLOS Genetics, Public Library of Science, vol. 7(2), pages 1-9, February.
    • Handle: RePEc:plo:pgen00:1001304
    DOI: 10.1371/journal.pgen.1001304
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    References listed on IDEAS

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    1. B. Devlin & Kathryn Roeder, 1999. "Genomic Control for Association Studies," Biometrics, The International Biometric Society, vol. 55(4), pages 997-1004, December.
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