IDEAS home Printed from https://ideas.repec.org/a/plo/pgen00/1001053.html
   My bibliography  Save this article

Multiple Independent Loci at Chromosome 15q25.1 Affect Smoking Quantity: a Meta-Analysis and Comparison with Lung Cancer and COPD

Author

Listed:
  • Nancy L Saccone
  • Robert C Culverhouse
  • Tae-Hwi Schwantes-An
  • Dale S Cannon
  • Xiangning Chen
  • Sven Cichon
  • Ina Giegling
  • Shizhong Han
  • Younghun Han
  • Kaisu Keskitalo-Vuokko
  • Xiangyang Kong
  • Maria Teresa Landi
  • Jennie Z Ma
  • Susan E Short
  • Sarah H Stephens
  • Victoria L Stevens
  • Lingwei Sun
  • Yufei Wang
  • Angela S Wenzlaff
  • Steven H Aggen
  • Naomi Breslau
  • Peter Broderick
  • Nilanjan Chatterjee
  • Jingchun Chen
  • Andrew C Heath
  • Markku Heliövaara
  • Nicole R Hoft
  • David J Hunter
  • Majken K Jensen
  • Nicholas G Martin
  • Grant W Montgomery
  • Tianhua Niu
  • Thomas J Payne
  • Leena Peltonen
  • Michele L Pergadia
  • John P Rice
  • Richard Sherva
  • Margaret R Spitz
  • Juzhong Sun
  • Jen C Wang
  • Robert B Weiss
  • William Wheeler
  • Stephanie H Witt
  • Bao-Zhu Yang
  • Neil E Caporaso
  • Marissa A Ehringer
  • Tim Eisen
  • Susan M Gapstur
  • Joel Gelernter
  • Richard Houlston
  • Jaakko Kaprio
  • Kenneth S Kendler
  • Peter Kraft
  • Mark F Leppert
  • Ming D Li
  • Pamela A F Madden
  • Markus M Nöthen
  • Sreekumar Pillai
  • Marcella Rietschel
  • Dan Rujescu
  • Ann Schwartz
  • Christopher I Amos
  • Laura J Bierut

Abstract

Recently, genetic association findings for nicotine dependence, smoking behavior, and smoking-related diseases converged to implicate the chromosome 15q25.1 region, which includes the CHRNA5-CHRNA3-CHRNB4 cholinergic nicotinic receptor subunit genes. In particular, association with the nonsynonymous CHRNA5 SNP rs16969968 and correlates has been replicated in several independent studies. Extensive genotyping of this region has suggested additional statistically distinct signals for nicotine dependence, tagged by rs578776 and rs588765. One goal of the Consortium for the Genetic Analysis of Smoking Phenotypes (CGASP) is to elucidate the associations among these markers and dichotomous smoking quantity (heavy versus light smoking), lung cancer, and chronic obstructive pulmonary disease (COPD). We performed a meta-analysis across 34 datasets of European-ancestry subjects, including 38,617 smokers who were assessed for cigarettes-per-day, 7,700 lung cancer cases and 5,914 lung-cancer-free controls (all smokers), and 2,614 COPD cases and 3,568 COPD-free controls (all smokers). We demonstrate statistically independent associations of rs16969968 and rs588765 with smoking (mutually adjusted p-values

Suggested Citation

  • Nancy L Saccone & Robert C Culverhouse & Tae-Hwi Schwantes-An & Dale S Cannon & Xiangning Chen & Sven Cichon & Ina Giegling & Shizhong Han & Younghun Han & Kaisu Keskitalo-Vuokko & Xiangyang Kong & Ma, 2010. "Multiple Independent Loci at Chromosome 15q25.1 Affect Smoking Quantity: a Meta-Analysis and Comparison with Lung Cancer and COPD," PLOS Genetics, Public Library of Science, vol. 6(8), pages 1-16, August.
    • Handle: RePEc:plo:pgen00:1001053
    DOI: 10.1371/journal.pgen.1001053
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1001053
    Download Restriction: no
    File URL: https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1001053&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pgen.1001053?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Krzysztof Chmielowiec & Jolanta Chmielowiec & Aleksandra Strońska-Pluta & Grzegorz Trybek & Małgorzata Śmiarowska & Aleksandra Suchanecka & Grzegorz Woźniak & Aleksandra Jaroń & Anna Grzywacz, 2022. "Association of Polymorphism CHRNA5 and CHRNA3 Gene in People Addicted to Nicotine," IJERPH, MDPI, vol. 19(17), pages 1-12, August.
    2. Xiao-Ying Wu & Shan-Yu Zhou & Zhong-Zheng Niu & Tao Liu & Chuan-Bo Xie & Wei-Qing Chen, 2015. "CHRNA3 rs6495308 Genotype as an Effect Modifier of the Association between Daily Cigarette Consumption and Hypertension in Chinese Male Smokers," IJERPH, MDPI, vol. 12(4), pages 1-14, April.
    3. Gloria Pérez-Rubio & Luis Alberto López-Flores & Ana Paula Cupertino & Francisco Cartujano-Barrera & Luz Myriam Reynales-Shigematsu & Mariana Ramírez & Edward F. Ellerbeck & Rosibel Rodríguez-Bolaños , 2021. "Genetic Variants in Smoking-Related Genes in Two Smoking Cessation Programs: A Cross-Sectional Study," IJERPH, MDPI, vol. 18(12), pages 1-13, June.
    4. Bierut, Laura & Biroli, Pietro & Galama, Titus J. & Thom, Kevin, 2023. "Challenges in studying the interplay of genes and environment. A study of childhood financial distress moderating genetic predisposition for peak smoking," Journal of Economic Psychology, Elsevier, vol. 98(C).

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pgen00:1001053. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosgenetics (email available below). General contact details of provider: https://journals.plos.org/plosgenetics/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.