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Multiple Independent Loci at Chromosome 15q25.1 Affect Smoking Quantity: a Meta-Analysis and Comparison with Lung Cancer and COPD

Author

Listed:
  • Nancy L Saccone
  • Robert C Culverhouse
  • Tae-Hwi Schwantes-An
  • Dale S Cannon
  • Xiangning Chen
  • Sven Cichon
  • Ina Giegling
  • Shizhong Han
  • Younghun Han
  • Kaisu Keskitalo-Vuokko
  • Xiangyang Kong
  • Maria Teresa Landi
  • Jennie Z Ma
  • Susan E Short
  • Sarah H Stephens
  • Victoria L Stevens
  • Lingwei Sun
  • Yufei Wang
  • Angela S Wenzlaff
  • Steven H Aggen
  • Naomi Breslau
  • Peter Broderick
  • Nilanjan Chatterjee
  • Jingchun Chen
  • Andrew C Heath
  • Markku Heliövaara
  • Nicole R Hoft
  • David J Hunter
  • Majken K Jensen
  • Nicholas G Martin
  • Grant W Montgomery
  • Tianhua Niu
  • Thomas J Payne
  • Leena Peltonen
  • Michele L Pergadia
  • John P Rice
  • Richard Sherva
  • Margaret R Spitz
  • Juzhong Sun
  • Jen C Wang
  • Robert B Weiss
  • William Wheeler
  • Stephanie H Witt
  • Bao-Zhu Yang
  • Neil E Caporaso
  • Marissa A Ehringer
  • Tim Eisen
  • Susan M Gapstur
  • Joel Gelernter
  • Richard Houlston
  • Jaakko Kaprio
  • Kenneth S Kendler
  • Peter Kraft
  • Mark F Leppert
  • Ming D Li
  • Pamela A F Madden
  • Markus M Nöthen
  • Sreekumar Pillai
  • Marcella Rietschel
  • Dan Rujescu
  • Ann Schwartz
  • Christopher I Amos
  • Laura J Bierut

Abstract

Recently, genetic association findings for nicotine dependence, smoking behavior, and smoking-related diseases converged to implicate the chromosome 15q25.1 region, which includes the CHRNA5-CHRNA3-CHRNB4 cholinergic nicotinic receptor subunit genes. In particular, association with the nonsynonymous CHRNA5 SNP rs16969968 and correlates has been replicated in several independent studies. Extensive genotyping of this region has suggested additional statistically distinct signals for nicotine dependence, tagged by rs578776 and rs588765. One goal of the Consortium for the Genetic Analysis of Smoking Phenotypes (CGASP) is to elucidate the associations among these markers and dichotomous smoking quantity (heavy versus light smoking), lung cancer, and chronic obstructive pulmonary disease (COPD). We performed a meta-analysis across 34 datasets of European-ancestry subjects, including 38,617 smokers who were assessed for cigarettes-per-day, 7,700 lung cancer cases and 5,914 lung-cancer-free controls (all smokers), and 2,614 COPD cases and 3,568 COPD-free controls (all smokers). We demonstrate statistically independent associations of rs16969968 and rs588765 with smoking (mutually adjusted p-values

Suggested Citation

  • Nancy L Saccone & Robert C Culverhouse & Tae-Hwi Schwantes-An & Dale S Cannon & Xiangning Chen & Sven Cichon & Ina Giegling & Shizhong Han & Younghun Han & Kaisu Keskitalo-Vuokko & Xiangyang Kong & Ma, 2010. "Multiple Independent Loci at Chromosome 15q25.1 Affect Smoking Quantity: a Meta-Analysis and Comparison with Lung Cancer and COPD," PLOS Genetics, Public Library of Science, vol. 6(8), pages 1-16, August.
    • Handle: RePEc:plo:pgen00:1001053
    DOI: 10.1371/journal.pgen.1001053
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    Cited by:

    1. Krzysztof Chmielowiec & Jolanta Chmielowiec & Aleksandra Strońska-Pluta & Grzegorz Trybek & Małgorzata Śmiarowska & Aleksandra Suchanecka & Grzegorz Woźniak & Aleksandra Jaroń & Anna Grzywacz, 2022. "Association of Polymorphism CHRNA5 and CHRNA3 Gene in People Addicted to Nicotine," IJERPH, MDPI, vol. 19(17), pages 1-12, August.
    2. Bierut, Laura & Biroli, Pietro & Galama, Titus J. & Thom, Kevin, 2023. "Challenges in studying the interplay of genes and environment. A study of childhood financial distress moderating genetic predisposition for peak smoking," Journal of Economic Psychology, Elsevier, vol. 98(C).
    3. Xiao-Ying Wu & Shan-Yu Zhou & Zhong-Zheng Niu & Tao Liu & Chuan-Bo Xie & Wei-Qing Chen, 2015. "CHRNA3 rs6495308 Genotype as an Effect Modifier of the Association between Daily Cigarette Consumption and Hypertension in Chinese Male Smokers," IJERPH, MDPI, vol. 12(4), pages 1-14, April.
    4. Gloria Pérez-Rubio & Luis Alberto López-Flores & Ana Paula Cupertino & Francisco Cartujano-Barrera & Luz Myriam Reynales-Shigematsu & Mariana Ramírez & Edward F. Ellerbeck & Rosibel Rodríguez-Bolaños , 2021. "Genetic Variants in Smoking-Related Genes in Two Smoking Cessation Programs: A Cross-Sectional Study," IJERPH, MDPI, vol. 18(12), pages 1-13, June.

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