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Genetic Variants in Smoking-Related Genes in Two Smoking Cessation Programs: A Cross-Sectional Study

Author

Listed:
  • Gloria Pérez-Rubio

    (HLA Laboratory, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Calzada de Tlalpan 4502, Sección XVI, Mexico City 14080, Mexico)

  • Luis Alberto López-Flores

    (HLA Laboratory, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Calzada de Tlalpan 4502, Sección XVI, Mexico City 14080, Mexico)

  • Ana Paula Cupertino

    (Department of Cancer Prevention and Control, Hackensack University Medical Center, Hackensack, NJ 07601, USA)

  • Francisco Cartujano-Barrera

    (Department of Cancer Prevention and Control, Hackensack University Medical Center, Hackensack, NJ 07601, USA)

  • Luz Myriam Reynales-Shigematsu

    (Department of Tobacco Research, Instituto Nacional de Salud Pública, Cuernavaca 62100, Mexico)

  • Mariana Ramírez

    (Department of Preventive Medicine and Public Health, University of Kansas Medical Center, Kansas City, KS 66160, USA)

  • Edward F. Ellerbeck

    (Department of Preventive Medicine and Public Health, University of Kansas Medical Center, Kansas City, KS 66160, USA)

  • Rosibel Rodríguez-Bolaños

    (Department of Tobacco Research, Instituto Nacional de Salud Pública, Cuernavaca 62100, Mexico)

  • Ramcés Falfan-Valencia

    (HLA Laboratory, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Calzada de Tlalpan 4502, Sección XVI, Mexico City 14080, Mexico)

Abstract

Previous studies have identified variants in genes encoding proteins associated with the degree of addiction, smoking onset, and cessation. We aimed to describe thirty-one single nucleotide polymorphisms (SNPs) in seven candidate genomic regions spanning six genes associated with tobacco-smoking in a cross-sectional study from two different interventions for quitting smoking: (1) thirty-eight smokers were recruited via multimedia to participate in e-Decídete! program (e-Dec) and (2) ninety-four attended an institutional smoking cessation program on-site. SNPs genotyping was done by real-time PCR using TaqMan probes. The analysis of alleles and genotypes was carried out using the EpiInfo v7. on-site subjects had more years smoking and tobacco index than e-Dec smokers ( p < 0.05, both); in CYP2A6 we found differences in the rs28399433 ( p < 0.01), the e-Dec group had a higher frequency of TT genotype (0.78 vs. 0.35), and TG genotype frequency was higher in the on-site group (0.63 vs. 0.18), same as GG genotype (0.03 vs. 0.02). Moreover, three SNPs in NRXN1 , two in CHRNA3 , and two in CHRNA5 had differences in genotype frequencies ( p < 0.01). Cigarettes per day were different ( p < 0.05) in the metabolizer classification by CYP2A6 alleles. In conclusion, subjects attending a mobile smoking cessation intervention smoked fewer cigarettes per day, by fewer years, and by fewer cumulative pack-years. There were differences in the genotype frequencies of SNPs in genes related to nicotine metabolism and nicotine dependence. Slow metabolizers smoked more cigarettes per day than intermediate and normal metabolizers.

Suggested Citation

  • Gloria Pérez-Rubio & Luis Alberto López-Flores & Ana Paula Cupertino & Francisco Cartujano-Barrera & Luz Myriam Reynales-Shigematsu & Mariana Ramírez & Edward F. Ellerbeck & Rosibel Rodríguez-Bolaños , 2021. "Genetic Variants in Smoking-Related Genes in Two Smoking Cessation Programs: A Cross-Sectional Study," IJERPH, MDPI, vol. 18(12), pages 1-13, June.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:12:p:6597-:d:577876
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    References listed on IDEAS

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    1. Nancy L Saccone & Robert C Culverhouse & Tae-Hwi Schwantes-An & Dale S Cannon & Xiangning Chen & Sven Cichon & Ina Giegling & Shizhong Han & Younghun Han & Kaisu Keskitalo-Vuokko & Xiangyang Kong & Ma, 2010. "Multiple Independent Loci at Chromosome 15q25.1 Affect Smoking Quantity: a Meta-Analysis and Comparison with Lung Cancer and COPD," PLOS Genetics, Public Library of Science, vol. 6(8), pages 1-16, August.
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