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Genome-Wide Association Studies of Serum Magnesium, Potassium, and Sodium Concentrations Identify Six Loci Influencing Serum Magnesium Levels

Author

Listed:
  • Tamra E Meyer
  • Germaine C Verwoert
  • Shih-Jen Hwang
  • Nicole L Glazer
  • Albert V Smith
  • Frank J A van Rooij
  • Georg B Ehret
  • Eric Boerwinkle
  • Janine F Felix
  • Tennille S Leak
  • Tamara B Harris
  • Qiong Yang
  • Abbas Dehghan
  • Thor Aspelund
  • Ronit Katz
  • Georg Homuth
  • Thomas Kocher
  • Rainer Rettig
  • Janina S Ried
  • Christian Gieger
  • Hanna Prucha
  • Arne Pfeufer
  • Thomas Meitinger
  • Josef Coresh
  • Albert Hofman
  • Mark J Sarnak
  • Yii-Der Ida Chen
  • André G Uitterlinden
  • Aravinda Chakravarti
  • Bruce M Psaty
  • Cornelia M van Duijn
  • W H Linda Kao
  • Jacqueline C M Witteman
  • Vilmundur Gudnason
  • David S Siscovick
  • Caroline S Fox
  • Anna Köttgen
  • The Genetic Factors for Osteoporosis (GEFOS) Consortium
  • Meta Analysis of Glucose and Insulin Related Traits Consortium (MAGIC)

Abstract

Magnesium, potassium, and sodium, cations commonly measured in serum, are involved in many physiological processes including energy metabolism, nerve and muscle function, signal transduction, and fluid and blood pressure regulation. To evaluate the contribution of common genetic variation to normal physiologic variation in serum concentrations of these cations, we conducted genome-wide association studies of serum magnesium, potassium, and sodium concentrations using ∼2.5 million genotyped and imputed common single nucleotide polymorphisms (SNPs) in 15,366 participants of European descent from the international CHARGE Consortium. Study-specific results were combined using fixed-effects inverse-variance weighted meta-analysis. SNPs demonstrating genome-wide significant (p

Suggested Citation

  • Tamra E Meyer & Germaine C Verwoert & Shih-Jen Hwang & Nicole L Glazer & Albert V Smith & Frank J A van Rooij & Georg B Ehret & Eric Boerwinkle & Janine F Felix & Tennille S Leak & Tamara B Harris & Q, 2010. "Genome-Wide Association Studies of Serum Magnesium, Potassium, and Sodium Concentrations Identify Six Loci Influencing Serum Magnesium Levels," PLOS Genetics, Public Library of Science, vol. 6(8), pages 1-11, August.
    • Handle: RePEc:plo:pgen00:1001045
    DOI: 10.1371/journal.pgen.1001045
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    Cited by:

    1. Jose A Seoane & Colin Campbell & Ian N M Day & Juan P Casas & Tom R Gaunt, 2014. "Canonical Correlation Analysis for Gene-Based Pleiotropy Discovery," PLOS Computational Biology, Public Library of Science, vol. 10(10), pages 1-13, October.
    2. Yu-Mei Chang & Erin Hadox & Balazs Szladovits & Oliver A Garden, 2016. "Serum Biochemical Phenotypes in the Domestic Dog," PLOS ONE, Public Library of Science, vol. 11(2), pages 1-17, February.

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