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Lactic Acid as Spacer between Poly Acrylic Acid and 4-Aminoantipyrine

Author

Listed:
  • Fiyral Mohammad Ali
  • Taghreed Hashim AL-Noor
  • Saif Mohsin Ali

Abstract

Due to many problems associated with drug release and side effects, we could design a novel drug delivery system through modification of poly acrylic acid (AA) with Lactic acid as a spacer between the polymer and 4-aminoantipyrine. In vitro drug release had been conducted successfully in basic medium in pH 7.4 and acidic medium in pH 1.1 at 37℃. The prepared prodrug polymer was characterized by FTIR and 1H−NMR spectra. Physical properties and intrinsic viscosity of drug polymer were determined. The good results were obtained in the presence of spacer unit with comparing without spacer unit.

Suggested Citation

  • Fiyral Mohammad Ali & Taghreed Hashim AL-Noor & Saif Mohsin Ali, 2015. "Lactic Acid as Spacer between Poly Acrylic Acid and 4-Aminoantipyrine," The International Journal of Biotechnology, Conscientia Beam, vol. 4(6), pages 36-45.
    • Handle: RePEc:pkp:tijobi:v:4:y:2015:i:6:p:36-45:id:1531
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