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Nonparametric variance estimation in the analysis of microarray data: a measurement error approach

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  • Raymond J. Carroll
  • Yuedong Wang

Abstract

We investigate the effects of measurement error on the estimation of nonparametric variance functions. We show that either ignoring measurement error or direct application of the simulation extrapolation, SIMEX, method leads to inconsistent estimators. Nevertheless, the direct SIMEX method can reduce bias relative to a naive estimator. We further propose a permutation SIMEX method that leads to consistent estimators in theory. The performance of both the SIMEX methods depends on approximations to the exact extrapolants. Simulations show that both the SIMEX methods perform better than ignoring measurement error. The methodology is illustrated using microarray data from colon cancer patients. Copyright 2008, Oxford University Press.

Suggested Citation

  • Raymond J. Carroll & Yuedong Wang, 2008. "Nonparametric variance estimation in the analysis of microarray data: a measurement error approach," Biometrika, Biometrika Trust, vol. 95(2), pages 437-449.
    • Handle: RePEc:oup:biomet:v:95:y:2008:i:2:p:437-449
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    File URL: http://hdl.handle.net/10.1093/biomet/asn017
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    Cited by:

    1. Garcia, Tanya P. & Ma, Yanyuan, 2017. "Simultaneous treatment of unspecified heteroskedastic model error distribution and mismeasured covariates for restricted moment models," Journal of Econometrics, Elsevier, vol. 200(2), pages 194-206.
    2. Jun Zhang & Zhenghui Feng & Peirong Xu & Hua Liang, 2017. "Generalized varying coefficient partially linear measurement errors models," Annals of the Institute of Statistical Mathematics, Springer;The Institute of Statistical Mathematics, vol. 69(1), pages 97-120, February.
    3. Xiao Min & Chen Ting & Huang Kunpeng & Ming Ruixing, 2020. "Optimal Estimation for Power of Variance with Application to Gene-Set Testing," Journal of Systems Science and Information, De Gruyter, vol. 8(6), pages 549-564, December.
    4. Michela Battauz & Ruggero Bellio, 2011. "Structural Modeling of Measurement Error in Generalized Linear Models with Rasch Measures as Covariates," Psychometrika, Springer;The Psychometric Society, vol. 76(1), pages 40-56, January.
    5. Li Cai & Lijian Yang, 2015. "A smooth simultaneous confidence band for conditional variance function," TEST: An Official Journal of the Spanish Society of Statistics and Operations Research, Springer;Sociedad de Estadística e Investigación Operativa, vol. 24(3), pages 632-655, September.
    6. J. R. Lockwood & Daniel F. McCaffrey, 2017. "Simulation-Extrapolation with Latent Heteroskedastic Error Variance," Psychometrika, Springer;The Psychometric Society, vol. 82(3), pages 717-736, September.

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