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Distinguishing externally from saccade-induced motion in visual cortex

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  • Satoru K. Miura

    (University of California, San Diego
    University of California
    University of California)

  • Massimo Scanziani

    (University of California, San Diego
    University of California
    University of California)

Abstract

Distinguishing sensory stimuli caused by changes in the environment from those caused by an animal’s own actions is a hallmark of sensory processing1. Saccades are rapid eye movements that shift the image on the retina. How visual systems differentiate motion of the image induced by saccades from actual motion in the environment is not fully understood2. Here we discovered that in mouse primary visual cortex (V1) the two types of motion evoke distinct activity patterns. This is because, during saccades, V1 combines the visual input with a strong non-visual input arriving from the thalamic pulvinar nucleus. The non-visual input triggers responses that are specific to the direction of the saccade and the visual input triggers responses that are specific to the direction of the shift of the stimulus on the retina, yet the preferred directions of these two responses are uncorrelated. Thus, the pulvinar input ensures differential V1 responses to external and self-generated motion. Integration of external sensory information with information about body movement may be a general mechanism for sensory cortices to distinguish between self-generated and external stimuli.

Suggested Citation

  • Satoru K. Miura & Massimo Scanziani, 2022. "Distinguishing externally from saccade-induced motion in visual cortex," Nature, Nature, vol. 610(7930), pages 135-142, October.
    • Handle: RePEc:nat:nature:v:610:y:2022:i:7930:d:10.1038_s41586-022-05196-w
    DOI: 10.1038/s41586-022-05196-w
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    Cited by:

    1. Guihua Xiao & Yeyi Cai & Yuanlong Zhang & Jingyu Xie & Lifan Wu & Hao Xie & Jiamin Wu & Qionghai Dai, 2024. "Mesoscale neuronal granular trial variability in vivo illustrated by nonlinear recurrent network in silico," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    2. Mir Ahsan Ali & Katharina Lischka & Stephanie J. Preuss & Chintan A. Trivedi & Johann H. Bollmann, 2023. "A synaptic corollary discharge signal suppresses midbrain visual processing during saccade-like locomotion," Nature Communications, Nature, vol. 14(1), pages 1-18, December.

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