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Independent infections of porcine deltacoronavirus among Haitian children

Author

Listed:
  • John A. Lednicky

    (University of Florida
    University of Florida)

  • Massimiliano S. Tagliamonte

    (University of Florida
    University of Florida)

  • Sarah K. White

    (University of Florida
    University of Florida)

  • Maha A. Elbadry

    (University of Florida
    University of Florida)

  • Md. Mahbubul Alam

    (University of Florida
    University of Florida)

  • Caroline J. Stephenson

    (University of Florida
    University of Florida)

  • Tania S. Bonny

    (University of Florida
    University of Florida)

  • Julia C. Loeb

    (University of Florida
    University of Florida)

  • Taina Telisma

    (Christianville Foundation)

  • Sonese Chavannes

    (Christianville Foundation)

  • David A. Ostrov

    (University of Florida
    University of Florida)

  • Carla Mavian

    (University of Florida
    University of Florida)

  • Valery Madsen Beau De Rochars

    (University of Florida
    University of Florida)

  • Marco Salemi

    (University of Florida
    University of Florida)

  • J. Glenn Morris

    (University of Florida
    University of Florida)

Abstract

Coronaviruses have caused three major epidemics since 2003, including the ongoing SARS-CoV-2 pandemic. In each case, the emergence of coronavirus in our species has been associated with zoonotic transmissions from animal reservoirs1,2, underscoring how prone such pathogens are to spill over and adapt to new species. Among the four recognized genera of the family Coronaviridae, human infections reported so far have been limited to alphacoronaviruses and betacoronaviruses3–5. Here we identify porcine deltacoronavirus strains in plasma samples of three Haitian children with acute undifferentiated febrile illness. Genomic and evolutionary analyses reveal that human infections were the result of at least two independent zoonoses of distinct viral lineages that acquired the same mutational signature in the genes encoding Nsp15 and the spike glycoprotein. In particular, structural analysis predicts that one of the changes in the spike S1 subunit, which contains the receptor-binding domain, may affect the flexibility of the protein and its binding to the host cell receptor. Our findings highlight the potential for evolutionary change and adaptation leading to human infections by coronaviruses outside of the previously recognized human-associated coronavirus groups, particularly in settings where there may be close human–animal contact.

Suggested Citation

  • John A. Lednicky & Massimiliano S. Tagliamonte & Sarah K. White & Maha A. Elbadry & Md. Mahbubul Alam & Caroline J. Stephenson & Tania S. Bonny & Julia C. Loeb & Taina Telisma & Sonese Chavannes & Dav, 2021. "Independent infections of porcine deltacoronavirus among Haitian children," Nature, Nature, vol. 600(7887), pages 133-137, December.
  • Handle: RePEc:nat:nature:v:600:y:2021:i:7887:d:10.1038_s41586-021-04111-z
    DOI: 10.1038/s41586-021-04111-z
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    Cited by:

    1. Wenjuan Du & Oliver Debski-Antoniak & Dubravka Drabek & Rien Haperen & Melissa Dortmondt & Joline Lee & Ieva Drulyte & Frank J. M. Kuppeveld & Frank Grosveld & Daniel L. Hurdiss & Berend-Jan Bosch, 2024. "Neutralizing antibodies reveal cryptic vulnerabilities and interdomain crosstalk in the porcine deltacoronavirus spike protein," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    2. Weiwei Ji & Qi Peng & Xueqiong Fang & Zehou Li & Yaxin Li & Cunfa Xu & Shuqing Zhao & Jizong Li & Rong Chen & Guoxiang Mo & Zhanyong Wei & Ying Xu & Bin Li & Shuijun Zhang, 2022. "Structures of a deltacoronavirus spike protein bound to porcine and human receptors," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    3. Michael H. J. Rhodin & Archie C. Reyes & Anand Balakrishnan & Nalini Bisht & Nicole M. Kelly & Joyce Sweeney Gibbons & Jonathan Lloyd & Michael Vaine & Tessa Cressey & Miranda Crepeau & Ruichao Shen &, 2024. "The small molecule inhibitor of SARS-CoV-2 3CLpro EDP-235 prevents viral replication and transmission in vivo," Nature Communications, Nature, vol. 15(1), pages 1-12, December.

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