IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v583y2020i7815d10.1038_s41586-020-2169-0.html
   My bibliography  Save this article

Identifying SARS-CoV-2-related coronaviruses in Malayan pangolins

Author

Listed:
  • Tommy Tsan-Yuk Lam

    (Guangdong-Hongkong Joint Laboratory of Emerging Infectious Diseases, Shantou University
    The University of Hong Kong)

  • Na Jia

    (Beijing Institute of Microbiology and Epidemiology)

  • Ya-Wei Zhang

    (Beijing Institute of Microbiology and Epidemiology)

  • Marcus Ho-Hin Shum

    (The University of Hong Kong)

  • Jia-Fu Jiang

    (Beijing Institute of Microbiology and Epidemiology)

  • Hua-Chen Zhu

    (Guangdong-Hongkong Joint Laboratory of Emerging Infectious Diseases, Shantou University
    The University of Hong Kong)

  • Yi-Gang Tong

    (Beijing University of Chemical Technology)

  • Yong-Xia Shi

    (Guangzhou Customs Technology Center)

  • Xue-Bing Ni

    (The University of Hong Kong)

  • Yun-Shi Liao

    (The University of Hong Kong)

  • Wen-Juan Li

    (Beijing University of Chemical Technology)

  • Bao-Gui Jiang

    (Beijing Institute of Microbiology and Epidemiology)

  • Wei Wei

    (Guangxi Medical University)

  • Ting-Ting Yuan

    (Beijing Institute of Microbiology and Epidemiology)

  • Kui Zheng

    (Guangzhou Customs Technology Center)

  • Xiao-Ming Cui

    (Beijing Institute of Microbiology and Epidemiology)

  • Jie Li

    (Beijing Institute of Microbiology and Epidemiology)

  • Guang-Qian Pei

    (Beijing Institute of Microbiology and Epidemiology)

  • Xin Qiang

    (Beijing Institute of Microbiology and Epidemiology)

  • William Yiu-Man Cheung

    (The University of Hong Kong)

  • Lian-Feng Li

    (Guangxi Medical University)

  • Fang-Fang Sun

    (Guangzhou Customs Technology Center)

  • Si Qin

    (Beijing Institute of Microbiology and Epidemiology)

  • Ji-Cheng Huang

    (Guangzhou Customs Technology Center)

  • Gabriel M. Leung

    (The University of Hong Kong)

  • Edward C. Holmes

    (The University of Sydney)

  • Yan-Ling Hu

    (Guangxi Medical University
    Guangxi Medical University)

  • Yi Guan

    (Guangdong-Hongkong Joint Laboratory of Emerging Infectious Diseases, Shantou University
    The University of Hong Kong)

  • Wu-Chun Cao

    (Beijing Institute of Microbiology and Epidemiology)

Abstract

The ongoing outbreak of viral pneumonia in China and across the world is associated with a new coronavirus, SARS-CoV-21. This outbreak has been tentatively associated with a seafood market in Wuhan, China, where the sale of wild animals may be the source of zoonotic infection2. Although bats are probable reservoir hosts for SARS-CoV-2, the identity of any intermediate host that may have facilitated transfer to humans is unknown. Here we report the identification of SARS-CoV-2-related coronaviruses in Malayan pangolins (Manis javanica) seized in anti-smuggling operations in southern China. Metagenomic sequencing identified pangolin-associated coronaviruses that belong to two sub-lineages of SARS-CoV-2-related coronaviruses, including one that exhibits strong similarity in the receptor-binding domain to SARS-CoV-2. The discovery of multiple lineages of pangolin coronavirus and their similarity to SARS-CoV-2 suggests that pangolins should be considered as possible hosts in the emergence of new coronaviruses and should be removed from wet markets to prevent zoonotic transmission.

Suggested Citation

  • Tommy Tsan-Yuk Lam & Na Jia & Ya-Wei Zhang & Marcus Ho-Hin Shum & Jia-Fu Jiang & Hua-Chen Zhu & Yi-Gang Tong & Yong-Xia Shi & Xue-Bing Ni & Yun-Shi Liao & Wen-Juan Li & Bao-Gui Jiang & Wei Wei & Ting-, 2020. "Identifying SARS-CoV-2-related coronaviruses in Malayan pangolins," Nature, Nature, vol. 583(7815), pages 282-285, July.
  • Handle: RePEc:nat:nature:v:583:y:2020:i:7815:d:10.1038_s41586-020-2169-0
    DOI: 10.1038/s41586-020-2169-0
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41586-020-2169-0
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.

    File URL: https://libkey.io/10.1038/s41586-020-2169-0?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Nicola F. Müller & Kathryn E. Kistler & Trevor Bedford, 2022. "A Bayesian approach to infer recombination patterns in coronaviruses," Nature Communications, Nature, vol. 13(1), pages 1-9, December.
    2. Xinyuan Cui & Kewei Fan & Xianghui Liang & Wenjie Gong & Wu Chen & Biao He & Xiaoyuan Chen & Hai Wang & Xiao Wang & Ping Zhang & Xingbang Lu & Rujian Chen & Kaixiong Lin & Jiameng Liu & Junqiong Zhai , 2023. "Virus diversity, wildlife-domestic animal circulation and potential zoonotic viruses of small mammals, pangolins and zoo animals," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    3. Yinxian Zhang, 2023. "Impactful COVID-19 discoveries from China are neglected in the media," Scientometrics, Springer;Akadémiai Kiadó, vol. 128(8), pages 4523-4539, August.
    4. Jun-Yu Si & Yuan-Mei Chen & Ye-Hui Sun & Meng-Xue Gu & Mei-Ling Huang & Lu-Lu Shi & Xiao Yu & Xiao Yang & Qing Xiong & Cheng-Bao Ma & Peng Liu & Zheng-Li Shi & Huan Yan, 2024. "Sarbecovirus RBD indels and specific residues dictating multi-species ACE2 adaptiveness," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    5. Yusuf Amuda Tajudeen & Iyiola Olatunji Oladunjoye & Ousman Bajinka & Habeebullah Jayeola Oladipo, 2022. "Zoonotic Spillover in an Era of Rapid Deforestation of Tropical Areas and Unprecedented Wildlife Trafficking: Into the Wild," Challenges, MDPI, vol. 13(2), pages 1-8, August.
    6. Ovidiu Tița & Maria Adelina Constantinescu & Mihaela Adriana Tița & Cecilia Georgescu, 2020. "Use of Yoghurt Enhanced with Volatile Plant Oils Encapsulated in Sodium Alginate to Increase the Human Body’s Immunity in the Present Fight Against Stress," IJERPH, MDPI, vol. 17(20), pages 1-17, October.
    7. Zepeng Xu & Xinrui Kang & Pu Han & Pei Du & Linjie Li & Anqi Zheng & Chuxia Deng & Jianxun Qi & Xin Zhao & Qihui Wang & Kefang Liu & George Fu Gao, 2022. "Binding and structural basis of equine ACE2 to RBDs from SARS-CoV, SARS-CoV-2 and related coronaviruses," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    8. Dinesh Kumar & Sejalben P. Antiya & Sandipkumar S. Patel & Ramesh Pandit & Madhvi Joshi & Abhinava K. Mishra & Chaitanya G. Joshi & Arunkumar C. Patel, 2022. "Surveillance and Molecular Characterization of SARS-CoV-2 Infection in Non-Human Hosts in Gujarat, India," IJERPH, MDPI, vol. 19(21), pages 1-11, November.
    9. Option Takunda Chiwaridzo & Reason Masengu, 2023. "The impact of social media branding and technology adoption on green tourism: the role of tourist behavior as a mediator in developing countries post-COVID-19—context of Zimbabwe," Future Business Journal, Springer, vol. 9(1), pages 1-14, December.
    10. Wenjuan Du & Oliver Debski-Antoniak & Dubravka Drabek & Rien Haperen & Melissa Dortmondt & Joline Lee & Ieva Drulyte & Frank J. M. Kuppeveld & Frank Grosveld & Daniel L. Hurdiss & Berend-Jan Bosch, 2024. "Neutralizing antibodies reveal cryptic vulnerabilities and interdomain crosstalk in the porcine deltacoronavirus spike protein," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    11. Luo-Yuan Xia & Zhen-Fei Wang & Xiao-Ming Cui & Yuan-Guo Li & Run-Ze Ye & Dai-Yun Zhu & Fang-Xu Li & Jie Zhang & Wen-Hao Wang & Ming-Zhu Zhang & Wan-Ying Gao & Lian-Feng Li & Teng-Cheng Que & Tie-Cheng, 2024. "Isolation and characterization of a pangolin-borne HKU4-related coronavirus that potentially infects human-DPP4-transgenic mice," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    12. Liang Leng & Zhichao Xu & Bixia Hong & Binbin Zhao & Ya Tian & Can Wang & Lulu Yang & Zhongmei Zou & Lingyu Li & Ke Liu & Wanjun Peng & Jiangning Liu & Zhoujie An & Yalin Wang & Baozhong Duan & Zhigan, 2024. "Cepharanthine analogs mining and genomes of Stephania accelerate anti-coronavirus drug discovery," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    13. Fabian Zech & Daniel Schniertshauer & Christoph Jung & Alexandra Herrmann & Arne Cordsmeier & Qinya Xie & Rayhane Nchioua & Caterina Prelli Bozzo & Meta Volcic & Lennart Koepke & Janis A. Müller & Jan, 2021. "Spike residue 403 affects binding of coronavirus spikes to human ACE2," Nature Communications, Nature, vol. 12(1), pages 1-10, December.
    14. Dongsheng Chen & Jian Sun & Jiacheng Zhu & Xiangning Ding & Tianming Lan & Xiran Wang & Weiying Wu & Zhihua Ou & Linnan Zhu & Peiwen Ding & Haoyu Wang & Lihua Luo & Rong Xiang & Xiaoling Wang & Jiayin, 2021. "Single cell atlas for 11 non-model mammals, reptiles and birds," Nature Communications, Nature, vol. 12(1), pages 1-17, December.
    15. Daniel N. Streblow & Alec J. Hirsch & Jeffrey J. Stanton & Anne D. Lewis & Lois Colgin & Ann J. Hessell & Craig N. Kreklywich & Jessica L. Smith & William F. Sutton & David Chauvin & Jennifer Woo & Be, 2023. "Aerosol delivery of SARS-CoV-2 human monoclonal antibodies in macaques limits viral replication and lung pathology," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    16. Yusuf Amuda Tajudeen & Habeebullah Jayeola Oladipo & Rashidat Onyinoyi Yusuf & Iyiola Olatunji Oladunjoye & Aminat Olaitan Adebayo & Abdulhakeem Funsho Ahmed & Mona Said El-Sherbini, 2022. "The Need to Prioritize Prevention of Viral Spillover in the Anthropopandemicene: A Message to Global Health Researchers and Policymakers," Challenges, MDPI, vol. 13(2), pages 1-9, August.
    17. Run-Ze Ye & Xiao-Yang Wang & Yu-Yu Li & Bao-Yu Wang & Ke Song & Yi-Fei Wang & Jing Liu & Bai-Hui Wang & Shan-Shan Wang & Qing Xu & Ze-Hui Li & Yi-Di Du & Jin-Yue Liu & Jia-Jing Zheng & Li-Feng Du & We, 2023. "Systematic review and integrated data analysis reveal diverse pangolin-associated microbes with infection potential," Nature Communications, Nature, vol. 14(1), pages 1-10, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:583:y:2020:i:7815:d:10.1038_s41586-020-2169-0. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.