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Identifying SARS-CoV-2-related coronaviruses in Malayan pangolins

Author

Listed:
  • Tommy Tsan-Yuk Lam

    (Guangdong-Hongkong Joint Laboratory of Emerging Infectious Diseases, Shantou University
    The University of Hong Kong)

  • Na Jia

    (Beijing Institute of Microbiology and Epidemiology)

  • Ya-Wei Zhang

    (Beijing Institute of Microbiology and Epidemiology)

  • Marcus Ho-Hin Shum

    (The University of Hong Kong)

  • Jia-Fu Jiang

    (Beijing Institute of Microbiology and Epidemiology)

  • Hua-Chen Zhu

    (Guangdong-Hongkong Joint Laboratory of Emerging Infectious Diseases, Shantou University
    The University of Hong Kong)

  • Yi-Gang Tong

    (Beijing University of Chemical Technology)

  • Yong-Xia Shi

    (Guangzhou Customs Technology Center)

  • Xue-Bing Ni

    (The University of Hong Kong)

  • Yun-Shi Liao

    (The University of Hong Kong)

  • Wen-Juan Li

    (Beijing University of Chemical Technology)

  • Bao-Gui Jiang

    (Beijing Institute of Microbiology and Epidemiology)

  • Wei Wei

    (Guangxi Medical University)

  • Ting-Ting Yuan

    (Beijing Institute of Microbiology and Epidemiology)

  • Kui Zheng

    (Guangzhou Customs Technology Center)

  • Xiao-Ming Cui

    (Beijing Institute of Microbiology and Epidemiology)

  • Jie Li

    (Beijing Institute of Microbiology and Epidemiology)

  • Guang-Qian Pei

    (Beijing Institute of Microbiology and Epidemiology)

  • Xin Qiang

    (Beijing Institute of Microbiology and Epidemiology)

  • William Yiu-Man Cheung

    (The University of Hong Kong)

  • Lian-Feng Li

    (Guangxi Medical University)

  • Fang-Fang Sun

    (Guangzhou Customs Technology Center)

  • Si Qin

    (Beijing Institute of Microbiology and Epidemiology)

  • Ji-Cheng Huang

    (Guangzhou Customs Technology Center)

  • Gabriel M. Leung

    (The University of Hong Kong)

  • Edward C. Holmes

    (The University of Sydney)

  • Yan-Ling Hu

    (Guangxi Medical University
    Guangxi Medical University)

  • Yi Guan

    (Guangdong-Hongkong Joint Laboratory of Emerging Infectious Diseases, Shantou University
    The University of Hong Kong)

  • Wu-Chun Cao

    (Beijing Institute of Microbiology and Epidemiology)

Abstract

The ongoing outbreak of viral pneumonia in China and across the world is associated with a new coronavirus, SARS-CoV-21. This outbreak has been tentatively associated with a seafood market in Wuhan, China, where the sale of wild animals may be the source of zoonotic infection2. Although bats are probable reservoir hosts for SARS-CoV-2, the identity of any intermediate host that may have facilitated transfer to humans is unknown. Here we report the identification of SARS-CoV-2-related coronaviruses in Malayan pangolins (Manis javanica) seized in anti-smuggling operations in southern China. Metagenomic sequencing identified pangolin-associated coronaviruses that belong to two sub-lineages of SARS-CoV-2-related coronaviruses, including one that exhibits strong similarity in the receptor-binding domain to SARS-CoV-2. The discovery of multiple lineages of pangolin coronavirus and their similarity to SARS-CoV-2 suggests that pangolins should be considered as possible hosts in the emergence of new coronaviruses and should be removed from wet markets to prevent zoonotic transmission.

Suggested Citation

  • Tommy Tsan-Yuk Lam & Na Jia & Ya-Wei Zhang & Marcus Ho-Hin Shum & Jia-Fu Jiang & Hua-Chen Zhu & Yi-Gang Tong & Yong-Xia Shi & Xue-Bing Ni & Yun-Shi Liao & Wen-Juan Li & Bao-Gui Jiang & Wei Wei & Ting-, 2020. "Identifying SARS-CoV-2-related coronaviruses in Malayan pangolins," Nature, Nature, vol. 583(7815), pages 282-285, July.
    • Handle: RePEc:nat:nature:v:583:y:2020:i:7815:d:10.1038_s41586-020-2169-0
    DOI: 10.1038/s41586-020-2169-0
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    2. Yinxian Zhang, 2023. "Impactful COVID-19 discoveries from China are neglected in the media," Scientometrics, Springer;Akadémiai Kiadó, vol. 128(8), pages 4523-4539, August.
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    4. Yusuf Amuda Tajudeen & Iyiola Olatunji Oladunjoye & Ousman Bajinka & Habeebullah Jayeola Oladipo, 2022. "Zoonotic Spillover in an Era of Rapid Deforestation of Tropical Areas and Unprecedented Wildlife Trafficking: Into the Wild," Challenges, MDPI, vol. 13(2), pages 1-8, August.
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    10. Nicola F. Müller & Kathryn E. Kistler & Trevor Bedford, 2022. "A Bayesian approach to infer recombination patterns in coronaviruses," Nature Communications, Nature, vol. 13(1), pages 1-9, December.
    11. Dinesh Kumar & Sejalben P. Antiya & Sandipkumar S. Patel & Ramesh Pandit & Madhvi Joshi & Abhinava K. Mishra & Chaitanya G. Joshi & Arunkumar C. Patel, 2022. "Surveillance and Molecular Characterization of SARS-CoV-2 Infection in Non-Human Hosts in Gujarat, India," IJERPH, MDPI, vol. 19(21), pages 1-11, November.
    12. Option Takunda Chiwaridzo & Reason Masengu, 2023. "The impact of social media branding and technology adoption on green tourism: the role of tourist behavior as a mediator in developing countries post-COVID-19—context of Zimbabwe," Future Business Journal, Springer, vol. 9(1), pages 1-14, December.
    13. Luo-Yuan Xia & Zhen-Fei Wang & Xiao-Ming Cui & Yuan-Guo Li & Run-Ze Ye & Dai-Yun Zhu & Fang-Xu Li & Jie Zhang & Wen-Hao Wang & Ming-Zhu Zhang & Wan-Ying Gao & Lian-Feng Li & Teng-Cheng Que & Tie-Cheng, 2024. "Isolation and characterization of a pangolin-borne HKU4-related coronavirus that potentially infects human-DPP4-transgenic mice," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    14. Liang Leng & Zhichao Xu & Bixia Hong & Binbin Zhao & Ya Tian & Can Wang & Lulu Yang & Zhongmei Zou & Lingyu Li & Ke Liu & Wanjun Peng & Jiangning Liu & Zhoujie An & Yalin Wang & Baozhong Duan & Zhigan, 2024. "Cepharanthine analogs mining and genomes of Stephania accelerate anti-coronavirus drug discovery," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    15. Dongsheng Chen & Jian Sun & Jiacheng Zhu & Xiangning Ding & Tianming Lan & Xiran Wang & Weiying Wu & Zhihua Ou & Linnan Zhu & Peiwen Ding & Haoyu Wang & Lihua Luo & Rong Xiang & Xiaoling Wang & Jiayin, 2021. "Single cell atlas for 11 non-model mammals, reptiles and birds," Nature Communications, Nature, vol. 12(1), pages 1-17, December.
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    17. Yusuf Amuda Tajudeen & Habeebullah Jayeola Oladipo & Rashidat Onyinoyi Yusuf & Iyiola Olatunji Oladunjoye & Aminat Olaitan Adebayo & Abdulhakeem Funsho Ahmed & Mona Said El-Sherbini, 2022. "The Need to Prioritize Prevention of Viral Spillover in the Anthropopandemicene: A Message to Global Health Researchers and Policymakers," Challenges, MDPI, vol. 13(2), pages 1-9, August.

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