IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v577y2020i7788d10.1038_s41586-019-1819-6.html
   My bibliography  Save this article

RGF1 controls root meristem size through ROS signalling

Author

Listed:
  • Masashi Yamada

    (Duke University
    Academia Sinica
    Academia Sinica)

  • Xinwei Han

    (Duke University
    GlaxoSmithKline)

  • Philip N. Benfey

    (Duke University)

Abstract

The stem cell niche and the size of the root meristem in plants are maintained by intercellular interactions and signalling networks involving a peptide hormone, root meristem growth factor 1 (RGF1)1. Understanding how RGF1 regulates the development of the root meristem is essential for understanding stem cell function. Although five receptors for RGF1 have been identified2–4, the downstream signalling mechanism remains unknown. Here we report a series of signalling events that follow RGF1 activity. We find that the RGF1-receptor pathway controls the distribution of reactive oxygen species (ROS) along the developmental zones of the Arabidopsis root. We identify a previously uncharacterized transcription factor, RGF1-INDUCIBLE TRANSCRIPTION FACTOR 1 (RITF1), that has a central role in mediating RGF1 signalling. Manipulating RITF1 expression leads to the redistribution of ROS along the root developmental zones. Changes in ROS distribution in turn enhance the stability of the PLETHORA2 protein, a master regulator of root stem cells. Our results thus clearly depict a signalling cascade that is initiated by RGF1, linking this peptide to mechanisms that regulate ROS.

Suggested Citation

  • Masashi Yamada & Xinwei Han & Philip N. Benfey, 2020. "RGF1 controls root meristem size through ROS signalling," Nature, Nature, vol. 577(7788), pages 85-88, January.
  • Handle: RePEc:nat:nature:v:577:y:2020:i:7788:d:10.1038_s41586-019-1819-6
    DOI: 10.1038/s41586-019-1819-6
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41586-019-1819-6
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.

    File URL: https://libkey.io/10.1038/s41586-019-1819-6?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Ping Li & Nana Xu & Yang Shui & Jie Zhang & Wuzhong Yin & Min Tian & Faping Guo & Dasong Bai & Pan Qi & Qingxiong Huang & Biluo Li & Yuanyuan Li & Yungao Hu & Youlin Peng, 2023. "Phenotypic Analysis and Gene Cloning of a New Allelic Mutant of SPL5 in Rice," Agriculture, MDPI, vol. 13(10), pages 1-16, September.
    2. Gilad Gabay & Hanchao Wang & Junli Zhang & Jorge I. Moriconi & German F. Burguener & Leonardo D. Gualano & Tyson Howell & Adam Lukaszewski & Brian Staskawicz & Myeong-Je Cho & Jaclyn Tanaka & Tzion Fa, 2023. "Dosage differences in 12-OXOPHYTODIENOATE REDUCTASE genes modulate wheat root growth," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    3. Tao Zhang & Sarah E. Noll & Jesus T. Peng & Amman Klair & Abigail Tripka & Nathan Stutzman & Casey Cheng & Richard N. Zare & Alexandra J. Dickinson, 2023. "Chemical imaging reveals diverse functions of tricarboxylic acid metabolites in root growth and development," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    4. Wen Shi & Lingyan Wang & Lianmei Yao & Wei Hao & Chao Han & Min Fan & Wenfei Wang & Ming-Yi Bai, 2022. "Spatially patterned hydrogen peroxide orchestrates stomatal development in Arabidopsis," Nature Communications, Nature, vol. 13(1), pages 1-12, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:577:y:2020:i:7788:d:10.1038_s41586-019-1819-6. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.