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Histone lactylation links metabolism and gene regulation

Author

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  • Luke T. Izzo
  • Kathryn E. Wellen

Abstract

Cells regulate gene expression in part through the chemical labelling of histone proteins. Discovery of a label derived from lactate molecules reveals a way in which cells link gene expression to nutrient metabolism.

Suggested Citation

  • Luke T. Izzo & Kathryn E. Wellen, 2019. "Histone lactylation links metabolism and gene regulation," Nature, Nature, vol. 574(7779), pages 492-493, October.
    • Handle: RePEc:nat:nature:v:574:y:2019:i:7779:d:10.1038_d41586-019-03122-1
    DOI: 10.1038/d41586-019-03122-1
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    Cited by:

    1. Ziping Niu & Chen Chen & Siyu Wang & Congcong Lu & Zhiyue Wu & Aiyuan Wang & Jing Mo & Jianji Zhang & Yanpu Han & Ye Yuan & Yingao Zhang & Yong Zang & Chaoran He & Xue Bai & Shanshan Tian & Guijin Zha, 2024. "HBO1 catalyzes lysine lactylation and mediates histone H3K9la to regulate gene transcription," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    2. Shuangshuang Sun & Zhe Xu & Liying He & Yihui Shen & Yuqing Yan & Xubing Lv & Xujing Zhu & Wei Li & Wei-Ya Tian & Yongjun Zheng & Sen Lin & Yadong Sun & Lei Li, 2024. "Metabolic regulation of cytoskeleton functions by HDAC6-catalyzed α-tubulin lactylation," Nature Communications, Nature, vol. 15(1), pages 1-14, December.

    More about this item

    Keywords

    Epigenetics; Metabolism;

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