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Harnessing innate immunity in cancer therapy

Author

Listed:
  • Olivier Demaria

    (Innate Pharma)

  • Stéphanie Cornen

    (Innate Pharma)

  • Marc Daëron

    (Aix Marseille Université, INSERM, CNRS, Centre d’Immunologie de Marseille-Luminy
    Institut Pasteur)

  • Yannis Morel

    (Innate Pharma)

  • Ruslan Medzhitov

    (Yale University School of Medicine)

  • Eric Vivier

    (Innate Pharma
    Aix Marseille Université, INSERM, CNRS, Centre d’Immunologie de Marseille-Luminy
    Service d’Immunologie, Marseille Immunopole, Hôpital de la Timone, Assistance Publique-Hôpitaux de Marseille)

Abstract

New therapies that promote antitumour immunity have been recently developed. Most of these immunomodulatory approaches have focused on enhancing T-cell responses, either by targeting inhibitory pathways with immune checkpoint inhibitors, or by targeting activating pathways, as with chimeric antigen receptor T cells or bispecific antibodies. Although these therapies have led to unprecedented successes, only a minority of patients with cancer benefit from these treatments, highlighting the need to identify new cells and molecules that could be exploited in the next generation of immunotherapy. Given the crucial role of innate immune responses in immunity, harnessing these responses opens up new possibilities for long-lasting, multilayered tumour control.

Suggested Citation

  • Olivier Demaria & Stéphanie Cornen & Marc Daëron & Yannis Morel & Ruslan Medzhitov & Eric Vivier, 2019. "Harnessing innate immunity in cancer therapy," Nature, Nature, vol. 574(7776), pages 45-56, October.
  • Handle: RePEc:nat:nature:v:574:y:2019:i:7776:d:10.1038_s41586-019-1593-5
    DOI: 10.1038/s41586-019-1593-5
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    Citations

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    Cited by:

    1. Qian-Ni Ye & Long Zhu & Jie Liang & Dong-Kun Zhao & Tai-Yu Tian & Ya-Nan Fan & Si-Yi Ye & Hua Liu & Xiao-Yi Huang & Zhi-Ting Cao & Song Shen & Jun Wang, 2024. "Orchestrating NK and T cells via tri-specific nano-antibodies for synergistic antitumor immunity," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    2. Yuedong Guo & Qunqun Bao & Ping Hu & Jianlin Shi, 2023. "Nanomedicine-based co-delivery of a calcium channel inhibitor and a small molecule targeting CD47 for lung cancer immunotherapy," Nature Communications, Nature, vol. 14(1), pages 1-20, December.
    3. Yu-Hsuan Chen & Han-Hsiun Chen & Won-Jing Wang & Hsin-Yi Chen & Wei-Syun Huang & Chien-Han Kao & Sin-Rong Lee & Nai Yang Yeat & Ruei-Liang Yan & Shu-Jou Chan & Kuen-Phon Wu & Ruey-Hwa Chen, 2023. "TRABID inhibition activates cGAS/STING-mediated anti-tumor immunity through mitosis and autophagy dysregulation," Nature Communications, Nature, vol. 14(1), pages 1-20, December.
    4. Eric H. Bent & Luis R. Millán-Barea & Iris Zhuang & Daniel R. Goulet & Julia Fröse & Michael T. Hemann, 2021. "Microenvironmental IL-6 inhibits anti-cancer immune responses generated by cytotoxic chemotherapy," Nature Communications, Nature, vol. 12(1), pages 1-13, December.
    5. Caihua Zhang & Kang Li & Hongzhang Zhu & Maosheng Cheng & Shuang Chen & Rongsong Ling & Cheng Wang & Demeng Chen, 2024. "ITGB6 modulates resistance to anti-CD276 therapy in head and neck cancer by promoting PF4+ macrophage infiltration," Nature Communications, Nature, vol. 15(1), pages 1-23, December.
    6. Katrin Rabold & Martijn Zoodsma & Inge Grondman & Yunus Kuijpers & Manita Bremmers & Martin Jaeger & Bowen Zhang & Willemijn Hobo & Han J. Bonenkamp & Johannes H. W. Wilt & Marcel J. R. Janssen & Lenn, 2022. "Reprogramming of myeloid cells and their progenitors in patients with non-medullary thyroid carcinoma," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    7. Mengxue Zhou & Jiaxin Wang & Jiaxing Pan & Hui Wang & Lujia Huang & Bo Hou & Yi Lai & Fengyang Wang & Qingxiang Guan & Feng Wang & Zhiai Xu & Haijun Yu, 2023. "Nanovesicles loaded with a TGF-β receptor 1 inhibitor overcome immune resistance to potentiate cancer immunotherapy," Nature Communications, Nature, vol. 14(1), pages 1-18, December.

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