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A calmodulin-gated calcium channel links pathogen patterns to plant immunity

Author

Listed:
  • Wang Tian

    (University of California)

  • Congcong Hou

    (University of California)

  • Zhijie Ren

    (Capital Normal University)

  • Chao Wang

    (University of California)

  • Fugeng Zhao

    (Nanjing University-Nanjing Forestry University Joint Institute for Plant Molecular Biology, College of Life Sciences, Nanjing University)

  • Douglas Dahlbeck

    (University of California)

  • Songping Hu

    (University of California)

  • Liying Zhang

    (Capital Normal University)

  • Qi Niu

    (Capital Normal University)

  • Legong Li

    (Capital Normal University)

  • Brian J. Staskawicz

    (University of California)

  • Sheng Luan

    (University of California)

Abstract

Pathogen-associated molecular patterns (PAMPs) activate innate immunity in both animals and plants. Although calcium has long been recognized as an essential signal for PAMP-triggered immunity in plants, the mechanism of PAMP-induced calcium signalling remains unknown1,2. Here we report that calcium nutrient status is critical for calcium-dependent PAMP-triggered immunity in plants. When calcium supply is sufficient, two genes that encode cyclic nucleotide-gated channel (CNGC) proteins, CNGC2 and CNGC4, are essential for PAMP-induced calcium signalling in Arabidopsis3–7. In a reconstitution system, we find that the CNGC2 and CNGC4 proteins together—but neither alone—assemble into a functional calcium channel that is blocked by calmodulin in the resting state. Upon pathogen attack, the channel is phosphorylated and activated by the effector kinase BOTRYTIS-INDUCED KINASE1 (BIK1) of the pattern-recognition receptor complex, and this triggers an increase in the concentration of cytosolic calcium8–10. The CNGC-mediated calcium entry thus provides a critical link between the pattern-recognition receptor complex and calcium-dependent immunity programs in the PAMP-triggered immunity signalling pathway in plants.

Suggested Citation

  • Wang Tian & Congcong Hou & Zhijie Ren & Chao Wang & Fugeng Zhao & Douglas Dahlbeck & Songping Hu & Liying Zhang & Qi Niu & Legong Li & Brian J. Staskawicz & Sheng Luan, 2019. "A calmodulin-gated calcium channel links pathogen patterns to plant immunity," Nature, Nature, vol. 572(7767), pages 131-135, August.
    • Handle: RePEc:nat:nature:v:572:y:2019:i:7767:d:10.1038_s41586-019-1413-y
    DOI: 10.1038/s41586-019-1413-y
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    Cited by:

    1. Jiaojiao Bai & Yuanyuan Zhou & Jianhang Sun & Kexin Chen & Yufang Han & Ranran Wang & Yanmin Zou & Mingshuo Du & Dongping Lu, 2023. "BIK1 protein homeostasis is maintained by the interplay of different ubiquitin ligases in immune signaling," Nature Communications, Nature, vol. 14(1), pages 1-14, December.

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