TOX transcriptionally and epigenetically programs CD8+ T cell exhaustion
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DOI: 10.1038/s41586-019-1325-x
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- Kateryna Onyshchenko & Ren Luo & Elena Guffart & Simone Gaedicke & Anca-Ligia Grosu & Elke Firat & Gabriele Niedermann, 2023. "Expansion of circulating stem-like CD8+ T cells by adding CD122-directed IL-2 complexes to radiation and anti-PD1 therapies in mice," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
- Solhwi Lee & Kunhee Lee & Hyeonjin Bae & Kyungmin Lee & Junghwa Lee & Junhui Ma & Ye Ji Lee & Bo Ryeong Lee & Woong-Yang Park & Se Jin Im, 2023. "Defining a TCF1-expressing progenitor allogeneic CD8+ T cell subset in acute graft-versus-host disease," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
- Haiyan Zhang & Xiaojing Luo & Wei Yang & Zhiying Wu & Zhicong Zhao & Xin Pei & Xue Zhang & Chonghao Chen & Josh Haipeng Lei & Qingxia Shi & Qi Zhao & Yanxing Chen & Wenwei Wu & Zhaolei Zeng & Huai-Qia, 2024. "YTHDF2 upregulation and subcellular localization dictate CD8 T cell polyfunctionality in anti-tumor immunity," Nature Communications, Nature, vol. 15(1), pages 1-20, December.
- William H. Tomaszewski & Jessica Waibl-Polania & Molly Chakraborty & Jonathan Perera & Jeremy Ratiu & Alexandra Miggelbrink & Donald P. McDonnell & Mustafa Khasraw & David M. Ashley & Peter E. Fecci &, 2022. "Neuronal CaMKK2 promotes immunosuppression and checkpoint blockade resistance in glioblastoma," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
- Tina Sarén & Giulia Saronio & Paula Marti Torrell & Xu Zhu & Josefin Thelander & Yasmin Andersson & Camilla Hofström & Marika Nestor & Anna Dimberg & Helena Persson & Mohanraj Ramachandran & Di Yu & M, 2023. "Complementarity-determining region clustering may cause CAR-T cell dysfunction," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
- Hao Wu & Xiufeng Zhao & Sophia M. Hochrein & Miriam Eckstein & Gabriela F. Gubert & Konrad Knöpper & Ana Maria Mansilla & Arman Öner & Remi Doucet-Ladevèze & Werner Schmitz & Bart Ghesquière & Sebasti, 2023. "Mitochondrial dysfunction promotes the transition of precursor to terminally exhausted T cells through HIF-1α-mediated glycolytic reprogramming," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
- Hideki Ogura & Jin Gohda & Xiuyuan Lu & Mizuki Yamamoto & Yoshio Takesue & Aoi Son & Sadayuki Doi & Kazuyuki Matsushita & Fumitaka Isobe & Yoshihiro Fukuda & Tai-Ping Huang & Takamasa Ueno & Naomi Mam, 2022. "Dysfunctional Sars-CoV-2-M protein-specific cytotoxic T lymphocytes in patients recovering from severe COVID-19," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
- Rui Sun & Chao Lei & Zhishan Xu & Xuemei Gu & Liu Huang & Liang Chen & Yi Tan & Min Peng & Kavitha Yaddanapudi & Leah Siskind & Maiying Kong & Robert Mitchell & Jun Yan & Zhongbin Deng, 2024. "Neutral ceramidase regulates breast cancer progression by metabolic programming of TREM2-associated macrophages," Nature Communications, Nature, vol. 15(1), pages 1-20, December.
- Feng Xie & Xiaoxue Zhou & Peng Su & Heyu Li & Yifei Tu & Jinjin Du & Chen Pan & Xiang Wei & Min Zheng & Ke Jin & Liyan Miao & Chao Wang & Xuli Meng & Hans Dam & Peter Dijke & Long Zhang & Fangfang Zho, 2022. "Breast cancer cell-derived extracellular vesicles promote CD8+ T cell exhaustion via TGF-β type II receptor signaling," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
- Moujtaba Y. Kasmani & Paytsar Topchyan & Ashley K. Brown & Ryan J. Brown & Xiaopeng Wu & Yao Chen & Achia Khatun & Donia Alson & Yue Wu & Robert Burns & Chien-Wei Lin & Matthew R. Kudek & Jie Sun & We, 2023. "A spatial sequencing atlas of age-induced changes in the lung during influenza infection," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
- Aurélie Durand & Nelly Bonilla & Théo Level & Zoé Ginestet & Amélie Lombès & Vincent Guichard & Mathieu Germain & Sébastien Jacques & Franck Letourneur & Marcio Cruzeiro & Carmen Marchiol & Gilles Ren, 2024. "Type 1 interferons and Foxo1 down-regulation play a key role in age-related T-cell exhaustion in mice," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
- Yi Liu & Brian Debo & Mingfeng Li & Zhennan Shi & Wanqiang Sheng & Yang Shi, 2021. "LSD1 inhibition sustains T cell invigoration with a durable response to PD-1 blockade," Nature Communications, Nature, vol. 12(1), pages 1-16, December.
- Leticia Laura Niborski & Paul Gueguen & Mengliang Ye & Allan Thiolat & Rodrigo Nalio Ramos & Pamela Caudana & Jordan Denizeau & Ludovic Colombeau & Raphaël Rodriguez & Christel Goudot & Jean-Michel Lu, 2022. "CD8+T cell responsiveness to anti-PD-1 is epigenetically regulated by Suv39h1 in melanomas," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
- Sonali Jindal & Nathan D. Pennock & Duanchen Sun & Wesley Horton & Michelle K. Ozaki & Jayasri Narasimhan & Alexandra Q. Bartlett & Sheila Weinmann & Paul E. Goss & Virginia F. Borges & Zheng Xia & Pe, 2021. "Postpartum breast cancer has a distinct molecular profile that predicts poor outcomes," Nature Communications, Nature, vol. 12(1), pages 1-15, December.
- Tereza Dvorakova & Veronica Finisguerra & Matteo Formenti & Axelle Loriot & Loubna Boudhan & Jingjing Zhu & Benoit J. Van den Eynde, 2024. "Enhanced tumor response to adoptive T cell therapy with PHD2/3-deficient CD8 T cells," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
- Emily N. Neubert & Julia M. DeRogatis & Sloan A. Lewis & Karla M. Viramontes & Pedro Ortega & Monique L. Henriquez & Rémi Buisson & Ilhem Messaoudi & Roberto Tinoco, 2023. "HMGB2 regulates the differentiation and stemness of exhausted CD8+ T cells during chronic viral infection and cancer," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
- Yi Zhang & Guanjue Xiang & Alva Yijia Jiang & Allen Lynch & Zexian Zeng & Chenfei Wang & Wubing Zhang & Jingyu Fan & Jiajinlong Kang & Shengqing Stan Gu & Changxin Wan & Boning Zhang & X. Shirley Liu , 2023. "MetaTiME integrates single-cell gene expression to characterize the meta-components of the tumor immune microenvironment," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
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