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Genomic insights into the 2016–2017 cholera epidemic in Yemen

Author

Listed:
  • François-Xavier Weill

    (Unité des Bactéries Pathogènes Entériques)

  • Daryl Domman

    (Wellcome Sanger Institute
    Los Alamos National Laboratory)

  • Elisabeth Njamkepo

    (Unité des Bactéries Pathogènes Entériques)

  • Abdullrahman A. Almesbahi

    (National Centre of Public Health Laboratories (NCPHL))

  • Mona Naji

    (National Centre of Public Health Laboratories (NCPHL))

  • Samar Saeed Nasher

    (National Centre of Public Health Laboratories (NCPHL))

  • Ankur Rakesh

    (Epicentre)

  • Abdullah M. Assiri

    (Ministry of Health)

  • Naresh Chand Sharma

    (Maharishi Valmiki Infectious Diseases Hospital)

  • Samuel Kariuki

    (Kenya Medical Research Institute)

  • Mohammad Reza Pourshafie

    (Pasteur Institute of Iran, Department of Bacteriology)

  • Jean Rauzier

    (Unité des Bactéries Pathogènes Entériques)

  • Abdinasir Abubakar

    (WHO Regional Office for the Eastern Mediterranean (EMRO))

  • Jane Y. Carter

    (Amref Health Africa)

  • Joseph F. Wamala

    (WHO)

  • Caroline Seguin

    (Médecins Sans Frontières (MSF))

  • Christiane Bouchier

    (Institut Pasteur, Plate-forme Génomique (PF1))

  • Thérèse Malliavin

    (Unité de Bioinformatique Structurale, UMR 3528, CNRS; C3BI, USR 3756, Institut Pasteur)

  • Bita Bakhshi

    (Tarbiat Modares University)

  • Hayder H. N. Abulmaali

    (Central Public Health Laboratory (CPHL))

  • Dhirendra Kumar

    (Maharishi Valmiki Infectious Diseases Hospital
    Translational Health Science and Technology Institute (THSTI))

  • Samuel M. Njoroge

    (Kenya Medical Research Institute)

  • Mamunur Rahman Malik

    (WHO Regional Office for the Eastern Mediterranean (EMRO))

  • John Kiiru

    (Kenya Medical Research Institute)

  • Francisco J. Luquero

    (Epicentre)

  • Andrew S. Azman

    (Johns Hopkins Bloomberg School of Public Health)

  • Thandavarayan Ramamurthy

    (Translational Health Science and Technology Institute (THSTI))

  • Nicholas R. Thomson

    (Wellcome Sanger Institute
    London School of Hygiene and Tropical Medicine)

  • Marie-Laure Quilici

    (Unité des Bactéries Pathogènes Entériques)

Abstract

Yemen is currently experiencing, to our knowledge, the largest cholera epidemic in recent history. The first cases were declared in September 2016, and over 1.1 million cases and 2,300 deaths have since been reported1. Here we investigate the phylogenetic relationships, pathogenesis and determinants of antimicrobial resistance by sequencing the genomes of Vibrio cholerae isolates from the epidemic in Yemen and recent isolates from neighbouring regions. These 116 genomic sequences were placed within the phylogenetic context of a global collection of 1,087 isolates of the seventh pandemic V. cholerae serogroups O1 and O139 biotype El Tor2–4. We show that the isolates from Yemen that were collected during the two epidemiological waves of the epidemic1—the first between 28 September 2016 and 23 April 2017 (25,839 suspected cases) and the second beginning on 24 April 2017 (more than 1 million suspected cases)—are V. cholerae serotype Ogawa isolates from a single sublineage of the seventh pandemic V. cholerae O1 El Tor (7PET) lineage. Using genomic approaches, we link the epidemic in Yemen to global radiations of pandemic V. cholerae and show that this sublineage originated from South Asia and that it caused outbreaks in East Africa before appearing in Yemen. Furthermore, we show that the isolates from Yemen are susceptible to several antibiotics that are commonly used to treat cholera and to polymyxin B, resistance to which is used as a marker of the El Tor biotype.

Suggested Citation

  • François-Xavier Weill & Daryl Domman & Elisabeth Njamkepo & Abdullrahman A. Almesbahi & Mona Naji & Samar Saeed Nasher & Ankur Rakesh & Abdullah M. Assiri & Naresh Chand Sharma & Samuel Kariuki & Moha, 2019. "Genomic insights into the 2016–2017 cholera epidemic in Yemen," Nature, Nature, vol. 565(7738), pages 230-233, January.
    • Handle: RePEc:nat:nature:v:565:y:2019:i:7738:d:10.1038_s41586-018-0818-3
    DOI: 10.1038/s41586-018-0818-3
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    Citations

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    Cited by:

    1. Yun Luo & Michael Payne & Sandeep Kaur & Sophie Octavia & Ruiting Lan, 2024. "Genomic evidence of two-staged transmission of the early seventh cholera pandemic," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
    2. Chrispin Chaguza & Innocent Chibwe & David Chaima & Patrick Musicha & Latif Ndeketa & Watipaso Kasambara & Chimwemwe Mhango & Upendo L. Mseka & Joseph Bitilinyu-Bangoh & Bernard Mvula & Wakisa Kipandu, 2024. "Genomic insights into the 2022–2023Vibrio cholerae outbreak in Malawi," Nature Communications, Nature, vol. 15(1), pages 1-15, December.

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