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Pathogen elimination by probiotic Bacillus via signalling interference

Author

Listed:
  • Pipat Piewngam

    (National Institutes of Health
    Mahidol University)

  • Yue Zheng

    (National Institutes of Health)

  • Thuan H. Nguyen

    (National Institutes of Health)

  • Seth W. Dickey

    (National Institutes of Health)

  • Hwang-Soo Joo

    (National Institutes of Health
    Duksung Women’s University)

  • Amer E. Villaruz

    (National Institutes of Health)

  • Kyle A. Glose

    (National Institutes of Health)

  • Emilie L. Fisher

    (National Institutes of Health)

  • Rachelle L. Hunt

    (National Institutes of Health)

  • Barry Li

    (National Institutes of Health)

  • Janice Chiou

    (National Institutes of Health)

  • Sujiraphong Pharkjaksu

    (Mahidol University)

  • Sunisa Khongthong

    (Rajamangala University of Technology Srivijaya)

  • Gordon Y. C. Cheung

    (National Institutes of Health)

  • Pattarachai Kiratisin

    (Mahidol University)

  • Michael Otto

    (National Institutes of Health)

Abstract

Probiotic nutrition is frequently claimed to improve human health. In particular, live probiotic bacteria obtained with food are thought to reduce intestinal colonization by pathogens, and thus to reduce susceptibility to infection. However, the mechanisms that underlie these effects remain poorly understood. Here we report that the consumption of probiotic Bacillus bacteria comprehensively abolished colonization by the dangerous pathogen Staphylococcus aureus in a rural Thai population. We show that a widespread class of Bacillus lipopeptides, the fengycins, eliminates S. aureus by inhibiting S. aureus quorum sensing—a process through which bacteria respond to their population density by altering gene regulation. Our study presents a detailed molecular mechanism that underlines the importance of probiotic nutrition in reducing infectious disease. We also provide evidence that supports the biological significance of probiotic bacterial interference in humans, and show that such interference can be achieved by blocking a pathogen’s signalling system. Furthermore, our findings suggest a probiotic-based method for S. aureus decolonization and new ways to fight S. aureus infections.

Suggested Citation

  • Pipat Piewngam & Yue Zheng & Thuan H. Nguyen & Seth W. Dickey & Hwang-Soo Joo & Amer E. Villaruz & Kyle A. Glose & Emilie L. Fisher & Rachelle L. Hunt & Barry Li & Janice Chiou & Sujiraphong Pharkjaks, 2018. "Pathogen elimination by probiotic Bacillus via signalling interference," Nature, Nature, vol. 562(7728), pages 532-537, October.
    • Handle: RePEc:nat:nature:v:562:y:2018:i:7728:d:10.1038_s41586-018-0616-y
    DOI: 10.1038/s41586-018-0616-y
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    Cited by:

    1. Jiezhou Pan & Guidong Gong & Qin Wang & Jiaojiao Shang & Yunxiang He & Chelsea Catania & Dan Birnbaum & Yifei Li & Zhijun Jia & Yaoyao Zhang & Neel S. Joshi & Junling Guo, 2022. "A single-cell nanocoating of probiotics for enhanced amelioration of antibiotic-associated diarrhea," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    2. Irene Soffritti & Maria D’Accolti & Luca Lanzoni & Antonella Volta & Matteo Bisi & Sante Mazzacane & Elisabetta Caselli, 2019. "The Potential Use of Microorganisms as Restorative Agents: An Update," Sustainability, MDPI, vol. 11(14), pages 1-17, July.

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